Making energy behaviour research relevant to policy: A tale of two studies

Within a context of shrinking government resources and greater pressure on academics and other researchers to generate ‘impact’ from (publically funded) research there is a greater need than ever to ensure that published research is readily usable by and relevant to policy end-users. Through examining and comparing two energy related evidence reviews commissioned by the UK government, this paper presents a set of recommendations for those researchers who seek to make their publications (in both the white and grey literature) more accessible, usable and relevant to those working in policy and practice domains

What works in changing energy-using behaviours in the home? A rapid evidence assessment

RAND Europe was commissioned by the Department of Energy & Climate Change (DECC) to undertake a Rapid Evidence Assessment* to understand “What works in changing energy-using behaviours in the home?”. The main objective was to answer this question by systematically reviewing the evidence around domestic behaviour change, with a particular focus on international evidence.In order to identify relevant studies, and avoid overlap with other previous evidence reviews, a set of search criteria was established. For inclusion, studies must:• Target energy-using behaviours in the home.• Consider at least one intervention.**• Go beyond the use of direct feedback on past energy use and pricing strategies to shift or reduce demand; and consider behaviour beyond one-off purchasing decisions (such as the installation of insulation or the purchase of energy-efficient appliances).• Measure a behaviour change in a real-world setting, either observed or self-reported.• Make a comparison between groups (e.g. between treatment and control groups), or across different time periods.No restrictions were applied regarding sample size; and both quantitative and qualitative studies were included.This report draws on 48 behaviour change programmes identified and selected through a systemic search process. These programmes involve a wide range of innovative approaches (such as the provision of Home Energy Reports that compare households’ consumption with their neighbours’) as well as more traditional approaches (including advertising campaigns)

Intermittent prophylactic antibiotics for bronchiectasis

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the safety and efficacy of intermittent prophylactic antibiotics in the treatment of adults and children with bronchiectasis

Unraveling information about supranuclear-dense matter from the complete binary neutron star coalescence process using future gravitational-wave detector networks

Gravitational waves provide us with an extraordinary tool to study the matter inside neutron stars. In particular, the postmerger signal probes an extreme temperature and density regime and will help reveal information about the equation of state of supranuclear-dense matter. Although current detectors are most sensitive to the signal emitted by binary neutron stars before the merger, the upgrades of existing detectors and the construction of the next generation of detectors will make postmerger detections feasible. For this purpose, we present a new analytical, frequency-domain model for the inspiral-merger-postmerger signal emitted by binary neutron stars systems. The inspiral and merger part of the signals are modeled with IMRPhenomD_NRTidalv2, and we describe the main emission peak of postmerger with a three-parameter Lorentzian, using two different approaches: one in which the Lorentzian parameters are kept free, and one in which we model them via quasi-universal relations. We test the performance of our new complete waveform model in parameter estimation analyses, studying simulated signals obtained from both our developed model and by injecting numerical relativity waveforms. We investigate the performance of different detector networks to determine the improvement that future detectors will bring to our analysis. We consider Advanced LIGO+ and Advanced Virgo+, KAGRA, and LIGO-India. We also study the possible impact of a detector with high sensitivity in the kilohertz band like NEMO, and finally we compare these results to the ones we obtain with third-generation detectors, the Einstein Telescope and the Cosmic Explorer.Comment: Published versio

The production and characterization of a new active lipase from Acremonium alcalophilum using a plant bioreactor

Background: Microorganisms are the most proficient decomposers in nature, using secreted enzymes in the hydrolysis of lignocellulose. As such, they present the most abundant source for discovery of new enzymes. Acremonium alcalophilum is the only known cellulolytic fungus that thrives in alkaline conditions and can be cultured readily in the laboratory. Its optimal conditions for growth are 30°C and pH 9.0-9.2. The genome sequence of Acremonium alcalophilum has revealed a large number of genes encoding biomass-degrading enzymes. Among these enzymes, lipases are interesting because of several industrial applications including biofuels, detergent, food processing and textile industries. Results: We identified a lipA gene in the genome sequence of Acremonium alcalophilum, encoding a protein with a predicted lipase domain with weak sequence identity to characterized enzymes. Unusually, the predicted lipase displays ≈ 30% amino acid sequence identity to both feruloyl esterase and lipase of Aspergillus niger. LipA, when transiently produced in Nicotiana benthamiana, accumulated to over 9% of total soluble protein. Plant-produced recombinant LipA is active towards p-nitrophenol esters of various carbon chain lengths with peak activity on medium-chain fatty acid (C8). The enzyme is also highly active on xylose tetra-acetate and oat spelt xylan. These results suggests that LipA is a novel lipolytic enzyme that possesses both lipase and acetylxylan esterase activity. We determined that LipA is a glycoprotein with pH and temperature optima at 8.0 and 40°C, respectively. Conclusion: Besides being the first heterologous expression and characterization of a gene coding for a lipase from A. alcalophilum, this report shows that LipA is very versatile exhibiting both acetylxylan esterase and lipase activities potentially useful for diverse industry sectors, and that tobacco is a suitable bioreactor for producing fungal proteins

Healthcare provider-led interventions to support medication adherence following ACS:a meta-analysis

The efficiency with which the anaerobic fungi (phylum Neocallimastigomycota) degrade plant biomass is well-recognized and in recent years has received renewed interest. To further understand the biological mechanisms that are utilized by the rumen anaerobic fungi to break down lignocellulose, we have used a transcriptomic approach to examine carbohydrate digestion by Neocallimastix frontalis, Piromyces rhizinflata, Orpinomyces joyonii, and Anaeromyces mucronatus cultured on several carbon sources. The number of predicted unique transcripts ranged from 6,633 to 12,751. Pfam domains were identified in 62–70% of the fungal proteins and were linked to gene ontology terms to infer the biological function of the transcripts. Most of the predicted functions are consistent across species suggesting a similar overall strategy evolved for successful colonization of the rumen. However, the presence of differential profiles in enzyme classes suggests that there may be also be niche specialization. All fungal species were found to express an extensive array of transcripts encoding carbohydrate active enzymes (CAZymes) ranging from 8.3 to 11.3% of the transcriptome. CAZyme families involved in hemicellulose digestion were the most abundant across all four fungi. This study provides additional insight into how anaerobic fungi have evolved to become specialists at breaking down the plant cell wall in the complex and, strictly anaerobic rumen ecosystem

International risk of the new variant COVID-19 importations originating in the United Kingdom

A fast-spreading SARS-CoV-2 variant identified in the United Kingdom in December 2020 has raised international alarm. We estimate that, in all 15 countries analyzed, there is at least a 50% chance the variant was imported by travelers from the United Kingdom by December 7th.Financial support was provided by the Health and Medical Research Fund, Food and Health Bureau, Government of the Hong Kong Special Administrative Region (grant no. COVID190118), the US National Institutes of Health (grant no. R01 AI151176) and CDC COVID Supplement (grant no. U01IP001136).Integrative Biolog

Risk for International Importations of Variant SARS-CoV-2 Originating in the United Kingdom

A fast-spreading severe acute respiratory syndrome coronavirus 2 variant identified in the United Kingdom in December 2020 has raised international alarm. We analyzed data from 15 countries and estimated that the chance that this variant was imported into these countries by travelers from the United Kingdom by December 7 is >50%.Financial support was provided by the Health and Medical Research Fund, Food and Health Bureau, Government of the Hong Kong Special Administrative Region (grant no. COVID190118), the US National Institutes of Health (grant no. R01 AI151176), and Centers for Disease Control and Prevention COVID Supplement (grant no. U01IP001136).Integrative Biolog