Understanding Metal–Semiconductor Plasmonic Resonance Coupling through Surface-Enhanced Raman Scattering

Although there has been intense research on plasmon-induced charge transfer within metal/semiconductor heterostructures, previous studies have all focused on the surface plasmonic resonance (SPR) of only noble metals. Herein and for the first time, we observe and take into account the plasmonic coupling between SPR of both noble-metal and semiconductor nanostructures. A W18O49/Ag heterostructure composed of metallic Ag nanoparticles (Ag NPs) and semiconducting W18O49 nanowires (W18O49 NWs) is designed and fabricated, which exhibits a broad and strong SPR absorption in the visible wavelength range. This SPR band is attributed to the SPR coupling between the SPR of both Ag NPs and W18O49 NWs. Surface-enhanced Raman scattering (SERS) is then used to reveal the interactions between the metal SPR, semiconductor SPR, and the heterostructure’s charge transfer (CT) process, demonstrating that such coupled SPR enhanced the heterostructure’s internal CT and SERS signals. Finally, we proposed a new coupled-plasmon-induced charge transfer mechanism to interpret the improved CT efficiency between the SERS substrate and molecules. Our work provides insight for further studies on plasmonic effects and interfacial charge transfer in metal/semiconductor heterostructures

Additional file 1 of Surface curvature-induced oriented assembly of sushi-like Janus therapeutic nanoplatform for combined chemodynamic therapy

Supplementary Material

High Power Density Tower-like Triboelectric Nanogenerator for Harvesting Arbitrary Directional Water Wave Energy

Wave energy is one of the most available energy sources in oceans. In this work, a design of high power density triboelectric nanogenerator (TENG) based on a tower structure is proposed for harvesting wave energy from arbitrary directions. Such tower-like TENG (T-TENG) consists of multiple units made of polytetrafluoroethylene balls and three-dimensional printed arc surface coated with melt adhesive reticulation nylon film. The power generation model coupled with the kinetic model for the T-TENG is proposed and discussed. The T-TENG can effectively convert arbitrary directional wave energy into electrical energy by utilizing charged balls rolling on an optimized arc surface due to ocean wave excitation. In addition, it is found that the power density of the present T-TENG increases linearly from 1.03 W/m3 to 10.6 W/m3 by increasing the units from 1 to 10 in one block. This supports that the power density of the T-TENG increases proportionally with the number of units connected in parallel without rectifiers due to its distinctive mechanism and structure. Therefore, the design of T-TENG provides an innovative and effective approach toward large-scale blue energy harvesting by connecting more blocks to form T-TENG networks

Mesoporous Nano-Badminton with Asymmetric Mass Distribution: How Nanoscale Architecture Affects the Blood Flow Dynamics

While the nanobio interaction is crucial in determining nanoparticles’ in vivo fate, a previous work on investigating nanoparticles’ interaction with biological barriers is mainly carried out in a static state. Nanoparticles’ fluid dynamics that share non-negligible impacts on their frequency of encountering biological hosts, however, is seldom given attention. Herein, inspired by badmintons’ unique aerodynamics, badminton architecture Fe3O4&mPDA (Fe3O4 = magnetite nanoparticle and mPDA = mesoporous polydopamine) Janus nanoparticles have successfully been synthesized based on a steric-induced anisotropic assembly strategy. Due to the “head” Fe3O4 having much larger density than the mPDA “cone”, it shows an asymmetric mass distribution, analogous to real badminton. Computational simulations show that nanobadmintons have a stable fluid posture of mPDA cone facing forward, which is opposite to that for the real badminton. The force analysis demonstrates that the badminton-like morphology and mass distribution endow the nanoparticles with a balanced motion around this posture, making its movement in fluid stable. Compared to conventional spherical Fe3O4@mPDA nanoparticles, the Janus nanoparticles with an asymmetric mass distribution have straighter blood flow trails and ∼50% reduced blood vessel wall encountering frequency, thus providing doubled blood half-life and ∼15% lower organ uptakes. This work provides novel methodology for the fabrication of unique nanomaterials, and the correlations between nanoparticle architectures, biofluid dynamics, organ uptake, and blood circulation time are successfully established, providing essential guidance for designing future nanocarriers

High Power Density Tower-like Triboelectric Nanogenerator for Harvesting Arbitrary Directional Water Wave Energy

Wave energy is one of the most available energy sources in oceans. In this work, a design of high power density triboelectric nanogenerator (TENG) based on a tower structure is proposed for harvesting wave energy from arbitrary directions. Such tower-like TENG (T-TENG) consists of multiple units made of polytetrafluoroethylene balls and three-dimensional printed arc surface coated with melt adhesive reticulation nylon film. The power generation model coupled with the kinetic model for the T-TENG is proposed and discussed. The T-TENG can effectively convert arbitrary directional wave energy into electrical energy by utilizing charged balls rolling on an optimized arc surface due to ocean wave excitation. In addition, it is found that the power density of the present T-TENG increases linearly from 1.03 W/m3 to 10.6 W/m3 by increasing the units from 1 to 10 in one block. This supports that the power density of the T-TENG increases proportionally with the number of units connected in parallel without rectifiers due to its distinctive mechanism and structure. Therefore, the design of T-TENG provides an innovative and effective approach toward large-scale blue energy harvesting by connecting more blocks to form T-TENG networks

Asymmetric Mesoporous Nanoformulation for Combination Treatment of Soft Tissue Sarcoma

Soft tissue sarcoma (STS) is a kind of tumor that is difficult to treat by chemotherapy alone. In recent years, various studies have been conducted on the use of multifunctional nanoparticles with core@shell or indiscriminate coassembly to improve therapeutic efficacy. However, in these multifunctional nanoformulations, the functional subunits are located in the relevant space, in which the different functions are difficult to perform independently during the combination therapy. Herein, the enwinding-structured asymmetric mesoporous Fe3O4&mSiO2–SRF nanoformulation (SRF = Sorafenib) is constructed for the combination therapy of STS, in which the one-dimensional mSiO2 nanorods are enwound on the surface of magnetic Fe3O4 nanoparticles. In this enwinding-structured asymmetric nanoformulation, a Fe3O4 nanosphere subunit is used for the chemodynamic therapy (CDT), and a mesoporous SiO2 (mSiO2) subunit with high surface area is used for the loading of SRF chemotherapy drugs (mSiO2–SRF). Taking advantage of the spatial isolation of mSiO2–SRF and Fe3O4 subunits, the direct exposure of the Fe3O4 subunit can not only enhance the Fenton reaction on the nanoparticles surface but also accelerate the release of Fe2+/Fe3+ in the acidic microenvironment of the tumor, which further induced the upgrade of the cell oxidation level through GSH consumption and CDT. In addition, the SRF loaded mSiO2 functional unit can inhibit the synthesis of GSH, and synergistically work with the Fe3O4 functional unit to enhance the ferroptosis of cancer cells. Compared with traditional core@shell structured nanoformulation, the cancer cell killing efficiency of the asymmetric mesoporous nanoformulation is greatly increased by 41.33%, thus realizing improved tumor restrain efficiency in STS treatment

High Power Density Tower-like Triboelectric Nanogenerator for Harvesting Arbitrary Directional Water Wave Energy

Wave energy is one of the most available energy sources in oceans. In this work, a design of high power density triboelectric nanogenerator (TENG) based on a tower structure is proposed for harvesting wave energy from arbitrary directions. Such tower-like TENG (T-TENG) consists of multiple units made of polytetrafluoroethylene balls and three-dimensional printed arc surface coated with melt adhesive reticulation nylon film. The power generation model coupled with the kinetic model for the T-TENG is proposed and discussed. The T-TENG can effectively convert arbitrary directional wave energy into electrical energy by utilizing charged balls rolling on an optimized arc surface due to ocean wave excitation. In addition, it is found that the power density of the present T-TENG increases linearly from 1.03 W/m3 to 10.6 W/m3 by increasing the units from 1 to 10 in one block. This supports that the power density of the T-TENG increases proportionally with the number of units connected in parallel without rectifiers due to its distinctive mechanism and structure. Therefore, the design of T-TENG provides an innovative and effective approach toward large-scale blue energy harvesting by connecting more blocks to form T-TENG networks

Enzyme-Based Mesoporous Nanomotors with Near-Infrared Optical Brakes

As one of the most important parameters of the nanomotors’ motion, precise speed control of enzyme-based nanomotors is highly desirable in many bioapplications. However, owing to the stable physiological environment, it is still very difficult to in situ manipulate the motion of the enzyme-based nanomotors. Herein, inspired by the brakes on vehicles, the near-infrared (NIR) “optical brakes” are introduced in the glucose-driven enzyme-based mesoporous nanomotors to realize remote speed regulation for the first time. The novel nanomotors are rationally designed and fabricated based on the Janus mesoporous nanostructure, which consists of the SiO2@Au core@shell nanospheres and the enzymes-modified periodic mesoporous organosilicas (PMOs). The nanomotor can be driven by the biofuel of glucose under the catalysis of enzymes (glucose oxidase/catalase) on the PMO domain. Meanwhile, the Au nanoshell at the SiO2@Au domain enables the generation of the local thermal gradient under the NIR light irradiation, driving the nanomotor by thermophoresis. Taking advantage of the unique Janus nanostructure, the directions of the driving force induced by enzyme catalysis and the thermophoretic force induced by NIR photothermal effect are opposite. Therefore, with the NIR optical speed regulators, the glucose-driven nanomotors can achieve remote speed manipulation from 3.46 to 6.49 μm/s (9.9–18.5 body-length/s) at the fixed glucose concentration, even after covering with a biological tissue. As a proof of concept, the cellar uptake of the such mesoporous nanomotors can be remotely regulated (57.5–109 μg/mg), which offers great potential for designing smart active drug delivery systems based on the mesoporous frameworks of this novel nanomotor

Flexible Seaweed-Like Triboelectric Nanogenerator as a Wave Energy Harvester Powering Marine Internet of Things

The marine internet of things (MIoT), an increasingly important foundation for ocean development and protection, consists of a variety of marine distributed sensors under water. These sensors of the MIoT have always been highly dependent on batteries. To realize in situ power supply, a flexible seaweed-like triboelectric nanogenerator (S-TENG) capable of harvesting wave energy is proposed in this study. The flexible structure, designed with inspiration from the seaweed structure, processes extensive marine application scenarios. The bending and recovering of the S-TENG structure under wave excitations are converted to electricity. As the output performance increases with the number of parallel connected S-TENG units, an S-TENG system with multiple units could serve for floating buoys, coastal power stations, and even submerged devices. Through the demonstration experiments performed in this study, the flexible, low-cost S-TENG could become an effective approach to achieve a battery independent MIoT

Spatially Asymmetric Nanoparticles for Boosting Ferroptosis in Tumor Therapy

Despite its effectiveness in eliminating cancer cells, ferroptosis is hindered by the high natural antioxidant glutathione (GSH) levels in the tumor microenvironment. Herein, we developed a spatially asymmetric nanoparticle, Fe3O4@DMS&PDA@MnO2-SRF, for enhanced ferroptosis. It consists of two subunits: Fe3O4 nanoparticles coated with dendritic mesoporous silica (DMS) and PDA@MnO2 (PDA: polydopamine) loaded with sorafenib (SRF). The spatial isolation of the Fe3O4@DMS and PDA@MnO2-SRF subunits enhances the synergistic effect between the GSH-scavengers and ferroptosis-related components. First, the increased exposure of the Fe3O4 subunit enhances the Fenton reaction, leading to increased production of reactive oxygen species. Furthermore, the PDA@MnO2-SRF subunit effectively depletes GSH, thereby inducing ferroptosis by the inactivation of glutathione-dependent peroxidases 4. Moreover, the SRF blocks Xc– transport in tumor cells, augmenting GSH depletion capabilities. The dual GSH depletion of the Fe3O4@DMS&PDA@MnO2-SRF significantly weakens the antioxidative system, boosting the chemodynamic performance and leading to increased ferroptosis of tumor cells