Comparison of ⁶⁸Ga-DOTATATE uptake and MR contrast agent enhancement.

<p>In all 3 patients, there is a marked overlap between ⁶⁸Ga-DOTATATE uptake and MR contrast agent enhancement. Radiotracer accumulation is most pronounced in areas with intense contrast enhancement. Shown are axial views of contrast-enhanced T1-weighted MR as well as fused MR/PET images.</p

Comparison of ⁶⁸Ga-DOTATATE and ¹⁸F-FET in GBM.

<p>A single patient (#15) underwent both SSTR- as well as amino acid-based PET. Both modalities show highly comparable tracer uptake.</p

Distribution of macrophage infiltration, tumor cell burden and proliferation (visual assessment) in GBM samples.

<p>Distribution of macrophage infiltration, tumor cell burden and proliferation (visual assessment) in GBM samples.</p

Correlation between histological macrophage infiltration (visual assessment) and ⁶⁸Ga-DOTATATE uptake in three different samples of GBM.

<p>Correlation between histological macrophage infiltration (visual assessment) and ⁶⁸Ga-DOTATATE uptake in three different samples of GBM.</p

Tracer distribution of ⁶⁸Ga-DOTATATE in GBM.

<p>Three examples of increased ⁶⁸Ga-DOTATATE uptake in Glioblastoma multiforme. Markedly, partly inhomogeneous tracer accumulation can be depicted in each patient. Shown are axial views of CT, SSTR-PET as well as fused PET/CT images.</p

Immunohistochemical staining of SSTR2A (sample of patient #15).

<p>(A) non-tumoral cortex with strong reaction in neurons (arrows) and neuropile (magnification: 100x). Left inset: Negative control. Right inset: positive control (normal pancreas) with strong reaction in an islet of Langerhans. (B) CD68 staining depicting high microglia/macrophage infiltration area and (C) SSTR2A immunostaining of an adjacent area showing strong reaction in endothelium (arrows) and in single glioma cells (arrowheads) (magnification: 100x).</p