Associations of two SNPs (rs3077, rs9277535) with chronic HBV infection and HBsAg seroclearance.

<p>Associations of two SNPs (rs3077, rs9277535) with chronic HBV infection and HBsAg seroclearance.</p

Comparison of association between each haplotype of rs3077-rs9277535 and HBsAg seroclearance.

<p>Comparison of association between each haplotype of rs3077-rs9277535 and HBsAg seroclearance.</p

Baseline characteristics of study cohorts.

<p>Baseline characteristics of study cohorts.</p

SVR₁₂ according to baseline patient characteristics and on-treatment HCV viral decline.

SVR12 according to baseline patient characteristics and on-treatment HCV viral decline.</p

Baseline patient characteristics.

Baseline patient characteristics.</p

Additional file 5: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Figure S4. Proliferation and cytokine production of intra-tumoral and splenic CD8+ and CD4+ T cells after re-stimulation. (PDF 275 kb

Additional file 6: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Figure S5. The expression of immune checkpoints on adoptively transferred TAA-specific CD8+ T cells. (PDF 163 kb

Additional file 4: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Figure S3. The expression of immune checkpoints on CD8+ T cells and CD4 + T cells from mice receiving HDI of pKT2/CLP-AKT-Ags-LUC, pT/Caggs-NRASV12 and pCMV(CAT)T7-SB100. (PDF 313 kb

Additional file 2: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Figure S1. Immune cell profiling in the liver or tumor tissues from mice receiving HDI of pKT2/CLP-AKT, pT/Caggs-NRASV12 and pCMV(CAT)T7-SB100. (PDF 627 kb

Additional file 3: of A novel spontaneous hepatocellular carcinoma mouse model for studying T-cell exhaustion in the tumor microenvironment

Figure S2. Characterization of OVA257-264-specific CTLs in HCC tumor microenvironment. (PDF 367 kb