4,955 research outputs found
Robust visual odometry using uncertainty models
In dense, urban environments, GPS by itself cannot be relied on to provide accurate positioning information. Signal reception issues (e.g. occlusion, multi-path effects) often prevent the GPS receiver from getting a positional lock, causing holes in the absolute positioning data. In order to keep assisting the driver, other sensors are required to track the vehicle motion during these periods of GPS disturbance. In this paper, we propose a novel method to use a single on-board consumer-grade camera to estimate the relative vehicle motion. The method is based on the tracking of ground plane features, taking into account the uncertainty on their backprojection as well as the uncertainty on the vehicle motion. A Hough-like parameter space vote is employed to extract motion parameters from the uncertainty models. The method is easy to calibrate and designed to be robust to outliers and bad feature quality. Preliminary testing shows good accuracy and reliability, with a positional estimate within 2 metres for a 400 metre elapsed distance. The effects of inaccurate calibration are examined using artificial datasets, suggesting a self-calibrating system may be possible in future work
Black hole thermodynamics from simulations of lattice Yang-Mills theory
We report on lattice simulations of 16 supercharge SU(N) Yang-Mills quantum
mechanics in the 't Hooft limit. Maldacena duality conjectures that in this
limit the theory is dual to IIA string theory, and in particular that the
behavior of the thermal theory at low temperature is equivalent to that of
certain black holes in IIA supergravity. Our simulations probe the low
temperature regime for N <= 5 and the intermediate and high temperature regimes
for N <= 12. We observe 't Hooft scaling and at low temperatures our results
are consistent with the dual black hole prediction. The intermediate
temperature range is dual to the Horowitz-Polchinski correspondence region, and
our results are consistent with smooth behavior there. We include the Pfaffian
phase arising from the fermions in our calculations where appropriate.Comment: 4 pages, 4 figure
Exact fuzzy sphere thermodynamics in matrix quantum mechanics
We study thermodynamical properties of a fuzzy sphere in matrix quantum
mechanics of the BFSS type including the Chern-Simons term. Various quantities
are calculated to all orders in perturbation theory exploiting the one-loop
saturation of the effective action in the large-N limit. The fuzzy sphere
becomes unstable at sufficiently strong coupling, and the critical point is
obtained explicitly as a function of the temperature. The whole phase diagram
is investigated by Monte Carlo simulation. Above the critical point, we obtain
perfect agreement with the all order results. In the region below the critical
point, which is not accessible by perturbation theory, we observe the Hagedorn
transition. In the high temperature limit our model is equivalent to a totally
reduced model, and the relationship to previously known results is clarified.Comment: 22 pages, 14 figures, (v2) some typos correcte
Perturbative dynamics of fuzzy spheres at large N
We clarify some peculiar aspects of the perturbative expansion around a
classical fuzzy-sphere solution in matrix models with a cubic term. While the
effective action in the large-N limit is saturated at the one-loop level, we
find that the ``one-loop dominance'' does not hold for generic observables due
to one-particle reducible diagrams. However, we may exploit the one-loop
dominance for the effective action and obtain various observables to all orders
from one-loop calculation by simply shifting the center of expansion to the
``quantum solution'', which extremizes the effective action. We confirm the
validity of this method by comparison with the direct two-loop calculation and
with Monte Carlo results in the 3d Yang-Mills-Chern-Simons matrix model. From
the all order result we find that the perturbative expansion has a finite
radius of convergence.Comment: 21 pages, 9 figures, (v2) all order analyses added, (v3) some typos
correcte
Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts.
Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were orthotopically transplanted into Lewis rats and either treated with RS (20 mg/kg/day) or vehicle. Rats were harvested 3, 5 and 7 days following transplantation. For binding studies, fresh-frozen sections of transplanted kidneys were incubated with lymph node lymphocytes (LNL) derived from transplanted rats. Additionally, immunohistology was performed with various monoclonal antibodies. In general, MMF resulted in better preservation of graft structure by 7 days. Cellular infiltration and tubular atrophy were less pronounced. At day 3, macrophages were diminished in MMF-treated animals to a high extent, while the number of T cells was almost identical to that of controls. In addition, the number of cells positive for MHC class II and LFA-1 was reduced in the MMF-treated animals. These findings correlated with the binding results. Three days following engraftment, LNL bound to MMF-treated kidneys to a lesser extent compared to controls. In conclusion, MMF resulted in a markedly reduced leucocytic infiltrate, presumably based on a reduced expression of lymphocytic adhesion molecules and an interaction with macrophages
Dynamical aspects of the fuzzy CP in the large reduced model with a cubic term
``Fuzzy CP^2'', which is a four-dimensional fuzzy manifold extension of the
well-known fuzzy analogous to the fuzzy 2-sphere (S^2), appears as a classical
solution in the dimensionally reduced 8d Yang-Mills model with a cubic term
involving the structure constant of the SU(3) Lie algebra. Although the fuzzy
S^2, which is also a classical solution of the same model, has actually smaller
free energy than the fuzzy CP^2, Monte Carlo simulation shows that the fuzzy
CP^2 is stable even nonperturbatively due to the suppression of tunneling
effects at large N as far as the coefficient of the cubic term () is
sufficiently large. As \alpha is decreased, both the fuzzy CP and the fuzzy
S^2 collapse to a solid ball and the system is essentially described by the
pure Yang-Mills model (\alpha = 0). The corresponding transitions are of first
order and the critical points can be understood analytically. The gauge group
generated dynamically above the critical point turns out to be of rank one for
both CP^2 and S^2 cases. Above the critical point, we also perform perturbative
calculations for various quantities to all orders, taking advantage of the
one-loop saturation of the effective action in the large-N limit. By
extrapolating our Monte Carlo results to N=\infty, we find excellent agreement
with the all order results.Comment: 27 pages, 7 figures, (v2) References added (v3) all order analyses
added, some typos correcte
EWSR1 prevents the induction of aneuploidy through direct regulation of Aurora B
EWSR1 (Ewing sarcoma breakpoint region 1) was originally identified as a part of an aberrant EWSR1/FLI1 fusion gene in Ewing sarcoma, the second most common pediatric bone cancer. Due to formation of the EWSR1/FLI1 fusion gene in the tumor genome, the cell loses one wild type EWSR1 allele. Our previous study demonstrated that the loss of ewsr1a (homologue of human EWSR1) in zebrafish leads to the high incidence of mitotic dysfunction, of aneuploidy, and of tumorigenesis in the tp53 mutant background. To dissect the molecular function of EWSR1, we successfully established a stable DLD-1 cell line that enables a conditional knockdown of EWSR1 using an Auxin Inducible Degron (AID) system. When both EWSR1 genes of DLD-1 cell were tagged with mini-AID at its 5′-end using a CRISPR/Cas9 system, treatment of the (AID-EWSR1/AID-EWSR1) DLD-1 cells with a plant-based Auxin (AUX) led to the significant levels of degradation of AID-EWSR1 proteins. During anaphase, the EWSR1 knockdown (AUX+) cells displayed higher incidence of lagging chromosomes compared to the control (AUX-) cells. This defect was proceeded by a lower incidence of the localization of Aurora B at inner centromeres, and by a higher incidence of the protein at Kinetochore proximal centromere compared to the control cells during pro/metaphase. Despite these defects, the EWSR1 knockdown cells did not undergo mitotic arrest, suggesting that the cell lacks the error correction mechanism. Significantly, the EWSR1 knockdown (AUX+) cells induced higher incidence of aneuploidy compared to the control (AUX-) cells. Since our previous study demonstrated that EWSR1 interacts with the key mitotic kinase, Aurora B, we generated replacement lines of EWSR1-mCherry and EWSR1:R565A-mCherry (a mutant that has low affinity for Aurora B) in the (AID-EWSR1/AID-EWSR1) DLD-1 cells. The EWSR1-mCherry rescued the high incidence of aneuploidy of EWSR1 knockdown cells, whereas EWSR1-mCherry:R565A failed to rescue the phenotype. Together, we demonstrate that EWSR1 prevents the induction of lagging chromosomes, and of aneuploidy through the interaction with Aurora B
NMR characterization of spin-1/2 alternating antiferromagnetic chains in the high-pressure phase of (VO)2P2O7
Local-susceptibility measurements via the NMR shifts of P and V
nuclei in the high-pressure phase of (VO)PO confirmed the
existence of a unique alternating antiferromagnetic chain with a zero-field
spin gap of 34 K. The P nuclear spin-lattice relaxation rate scales with
the uniform spin susceptibility below about 15 K which shows that the
temperature dependence of both the static and dynamical spin susceptibilities
becomes identical at temperatures not far below the spin-gap energy.Comment: 6 pages, 5 figures; To be published in J. Phys. Condens. Matte
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