Supplementary Tables 1-2, Figures 1-4 from Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma

PDF file - 970K</p

Supplementary Data from The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma

Supplementary methods and materials and figure legends</p

Supplementary Data from The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma

Supplementary Table 1. Association between OS/RFS and expression group of mPGES1 and CD8 in stage III melanoma.</p

Supplementary Data from The COX2 Effector Microsomal PGE2 Synthase 1 is a Regulator of Immunosuppression in Cutaneous Melanoma

Supplementary Figure 1. Gating strategies for flow cytometry data analysis. Supplementary Figure 2. Co-staining of mPGES1 and S100 in human melanoma tissues. Supplementary Figure 3. Chemokines/cytokines related to COX2 or mPGES1 in melanoma. Supplementary Figure 4. Effect of COX2 or mPGES1 inhibitors on surface expression of PD-L1. Supplementary Figure 5. Comparison of PGE2 level and cell viability in scramble, PTGES KO and PTGS1/PTGS2 double KO mouse melanoma cell lines. Supplementary Figure 6. Prognostic effect of mPGES1 in Stage IV melanoma. Supplementary Figure 7. Association between mPGES1 levels and response of anti-PD-1 therapy.</p

Supplementary Figures and Tables from Hypoxia-Driven Mechanism of Vemurafenib Resistance in Melanoma

Figure S1. Chemical Structure of MSC2156119J (Tepotinib, EMD 1214063); Figure S2. Morphology of melanoma cell 2D ambient air cultures and spheroids; Figure S3. The immunofluorescent staining of DAPI and LOX-1 in A375 2D ambient air cultures; Figure S4. The immunofluorescent staining of LOX-1 in MEL1617 3D spheroids on day 3 and 8 of cultures; Figure S5. The human phospho-kinase antibody array of 451Lu spheroids and 2D ambient air cultures; Figure S6. The human phospho-kinase antibody array of A375 spheroids and 2D ambient air cultures; Figure S7. Effect of PLX4032 on BRAF-ERK pathway in melanoma cells under hypoxic conditions. Supplementary Table S1: Primers for RT-PCR and Real-time PCR; Supplementary Table S2: Patient Characteristics; Supplementary Table S3: List of cutaneous melanoma cell lines in CCLE project</p

Supplementary Data from Targeted Inhibition of Inducible Nitric Oxide Synthase Inhibits Growth of Human Melanoma <i>In vivo</i> and Synergizes with Chemotherapy

Supplementary Data from Targeted Inhibition of Inducible Nitric Oxide Synthase Inhibits Growth of Human Melanoma In vivo and Synergizes with Chemotherap

Supplementary Table S1 from Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma

This file contains distribution of the markers in discovery and validation set samples</p

Supplemantary Figure S2 from Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma

Clinical outcomes by CD74 categorical expression (both number and intensity) in tumor cells (A) in discovery and (B) in validation datasets of stage III melanoma patients. Kaplan-Meier analyses are shown for OS and RFS.</p

Supplementary Table S2 from Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma

This table contains multivariable Cox Analyses on survival models in validation set</p

Supplementary Material S1 from Inflammatory Marker Testing Identifies CD74 Expression in Melanoma Tumor Cells, and Its Expression Associates with Favorable Survival for Stage III Melanoma

This text includes the primary antibodies which were previously tested and validated by us for IHC using tumor and controls.</p