MOESM1 of Regulatory effects of COL1A1 on apoptosis induced by radiation in cervical cancer cells

Additional file 1: Figure S1. The regulated effect of COL1A1 on apoptosis tested by flow cytometry. In CaSki and HeLa cells, both COL1A1 shRNA transfection and LY294002 could induce apoptosis. COL1A1 activation could inhibit the apoptosis caused by LY294002, and the combination of COL1A1 shRNA transfection and LY294002 could induce much more apoptosis

Robust {Cd₄}‑Organic Framework for Efficiently Catalyzing CO₂ Cycloaddition and Knoevenagel Condensation

The high-value-added carbonates generated from CO2 have attracted the attention of more and more researchers because of which the optimization of metal–organic framework (MOF)-based catalysts has seen a considerable upsurge at present. The scarcely reported cadmium(II)-based MOFs inspire us to explore CdOFs with excellent catalytic activity and high reusability. Herein, the unification of the unreported {Cd4(μ3-OH)2(CH3CO2–)} cluster and 2,6-bis(2,4-dicarboxylphenyl)-4-(4-carboxylphenyl)pyridine (H5BDCP) led to a highly robust nanoporous crystalline material of {(Me2NH2)5[Cd4(BDCP)2(μ3-OH)2(CH3CO2)(H2O)2]·3DMF·2H2O}n (NUC-67) with 57.4% void volume. Structural analysis displays that the inner surface of channels in activated NUC-67a is functionalized by Lewis acid sites of unsaturated Cd2+ ions and Lewis base sites of μ3-OH– groups, CH3CO2– anions, free pyridine, and CO groups. Under solvent-free conditions, NUC-67a exhibits high catalytic performance on the cycloaddition of CO2 with epoxides; for instance, the conversion rate of propylene oxide (PO) into propylene carbonate (PC) with 1 atm CO2 can reach 99% within 6 h at 55 °C, resulting in a 660 turnover number and 110 h–1 turnover frequency. Moreover, Knoevenagel condensation reactions of aldehydes and malononitrile can be efficiently catalyzed by activated NUC-67a. Encouragingly, NUC-67a shows strong structural stability and good reversible cyclicity in the above two organic reactions with metal leaching below 8 ppb. Hence, this work proves that the optimization of MOF-based catalysts should focus on the design and selection of organic ligands, which plays a decisive role in structural regulation, such as cluster-based nodes, high defect of metal sites, unexpected insertion of Lewis base sites, and high-porosity channels

Characteristics of the included studies.

<p>RCT, randomized controlled trial; HMP, hypothermic machine perfusion; CS, cold storage; CIT, cold ischemic time; HTK, histidine–tryptophan–ketoglutarate;WIT, warm ischemic time; N/A, unavailable; ALG, antilymphocyte globulin; KPS-1, kidney preservation solution-1; UW, University of Wisconsin.</p

Search strategies.

<p>Search strategies.</p

One-year patient survival for ECD kidneys preserved by HMP versus CS.

<p>One-year patient survival for ECD kidneys preserved by HMP versus CS.</p

PNF rates for ECD kidneys preserved by HMP versus CS.

<p>PNF rates for ECD kidneys preserved by HMP versus CS.</p

Evaluation criteria adapted from Downs and Black (1998).

<p>Evaluation criteria adapted from Downs and Black (1998).</p

One-year graft survival for ECD kidneys preserved by HMP versus CS.

<p>One-year graft survival for ECD kidneys preserved by HMP versus CS.</p

DGF rates for ECD kidneys preserved by HMP versus CS.

<p>DGF rates for ECD kidneys preserved by HMP versus CS.</p

Flow chart illustrating papers selected for analysis.

<p>Flow chart illustrating papers selected for analysis.</p