Iodo-Controlled Selective Formation of Pyrrolidino[60]fullerene and Aziridino[60]fullerene from the Reaction between C₆₀ and Amino Acid Esters

The reaction between glycine methyl ester and C60 can be effectively controlled by different iodo-reagents. Addition of DIB ((diacetoxyiodo)benzene) yields the 2,5-bismethoxycarbonyl pyrrolidino[60]fullerene under ultrasonic irradiation; whereas addition of DIB-iodine results in the N-methoxycarbonylmethyl aziridino[60]fullerene under ultrasonic irradiation. The reaction of sarcosine methyl ester with C60 is similar to that of glycine methyl ester under these two conditions. Addition of just iodine to a mixture of sarcosine methyl ester and C60 affords the tetra(amino)[60]fullerene epoxide C60(O)((Me)NCH2COOMe)4. Possible mechanisms are discussed

Meta-analyses of mean IOP and IOP fluctuation.

Meta-analyses of mean IOP and IOP fluctuation.</p

Forest plot of the IOP fluctuation, comparison of LTFC and TTFC.

Forest plot of the IOP fluctuation, comparison of LTFC and TTFC.</p

Flow diagram of the study selection as per the PRISMA statement.

Flow diagram of the study selection as per the PRISMA statement.</p

Forest plot of the mean IOP, comparison of LTFC and DTFC.

Forest plot of the mean IOP, comparison of LTFC and DTFC.</p

Forest plot of the mean IOP, comparison of LTFC and TTFC.

Forest plot of the mean IOP, comparison of LTFC and TTFC.</p

Forest plot of the mean IOP, comparison of LTFC and BiTFC.

Forest plot of the mean IOP, comparison of LTFC and BiTFC.</p

Solvent Effects Used for Optimal Simultaneous Analysis of Amino Acids via ¹⁹F NMR Spectroscopy

19F NMR has been extensively used in simultaneous analysis of multicomponent due to its 100% natural isotope abundance, high NMR-sensitivity, and wide-range chemical shifts. The solvent effects are usually observed in NMR spectroscopy and cause large changes in 19F chemical shifts. Herein, we propose that the simultaneous analysis of a complex mixture can be achieved using solvent effects via19F NMR spectroscopy, such as a mixture solution of amino acids (AAs). AAs are not only cell-signaling molecules, but are also considered as biomarkers of some diseases. Hence, the analysis of AAs is important for human health and the diagnosis of diseases. In this work, the key to the success of sensing 19 biogenic AAs is the use of 2-fluorobenzaldehyde (2FBA) as a highly sensitive derivatizing agent and solvent effects to produce distinguishable 19F NMR signals. As a result, the resolution of 19F NMR spectroscopy of multiple 2FBA-labeled AAs is obviously higher than other methods based on 19F NMR. Moreover, 14 and 18 AAs can be satisfactorily differentiated and unambiguously identified in different complicated media supporting the growth of mammalian cells. Furthermore, quantification of the concentration of AAs can be made, and the limit of detection reaches 10 μM. Our work provides new insights into the simultaneous analysis of a multicomponent mixture based on solvent effects by 19F NMR spectroscopy

Forest plot of the IOP fluctuation, comparison of LTFC and DTFC.

Forest plot of the IOP fluctuation, comparison of LTFC and DTFC.</p

Quality assessment of meta-analyses.

Quality assessment of meta-analyses.</p