Time trend in the number of infants delivered with low birth weight per 1,000 live births.

<p>Time trend smoothed using the Stata loess smoother with bandwidth = 0.1.</p

Multivariable analysis of the step and slope per annum changes in pregnancy outcomes from 1 January 2006 referent to the underlying trend.

<p>Data are step changes at 1 January 2006, and slope changes after 1 January 2006. Data adjusted for maternal age, infant sex, deprivation quintile, week of conception, number of previous spontaneous abortions, number of previous therapeutic abortions, and parity.</p>a<p>Includes current, never, and former smokers and unknown smoking status.</p

Time trend in the number of infants delivered small for gestational age per 1,000 live births.

<p>Time trend smoothed using the Stata loess smoother with bandwidth = 0.1.</p

Univariate analysis of the step and slope per annum changes in pregnancy outcomes from 1 January 2006 referent to the underlying trend.

<p>Data are step changes at 1 January 2006, and slope changes after 1 January 2006.</p>a<p>Includes current, never, and former smokers and unknown smoking status.</p

Observed and predicted live birth rates from updated IVFpredict and Templeton models stratified by characteristics of patients and treatment, in 130,960 IVF cycles.

<p>P-values are for differences between observed and predicted number of live births, and those smaller than the threshold for a family-wise error rate of 5% are highlighted.</p><p>* Not including 5 cycles where cervical cause of infertility only, for which meaningful confidence intervals cannot be calculated.</p><p>Observed and predicted live birth rates from updated IVFpredict and Templeton models stratified by characteristics of patients and treatment, in 130,960 IVF cycles.</p

Time trend in the number of infants delivered preterm per 1,000 live births.

<p>Time trend smoothed using the Stata loess smoother with bandwidth = 0.1.</p

Characteristics of patients and treatment in the validation sample, consisting of 130,960 IVF cycles.

<p>Characteristics of patients and treatment in the validation sample, consisting of 130,960 IVF cycles.</p

Inclusion/exclusion criteria and formation of the validation sample.

<p>Inclusion/exclusion criteria and formation of the validation sample.</p

Calibration plot for updated IVFpredict and Templeton models.

<p>Based on 130,960 IVF cycles. Hosmer-Lemeshow test statistics: p<0.001. Solid line, updated IVFpredict model; dashed line, updated Templeton model; dotted, diagonal line, perfect prediction (reference).</p

Characteristics of study participants by test result.

<p>Characteristics of study participants by test result.</p