sj-docx-1-sgo-10.1177_21582440231199320 – Supplemental material for Understanding Blockchain Technology Adoption in Operation and Supply Chain Management of Pakistan: Extending UTAUT Model With Technology Readiness, Technology Affinity and Trust

Supplemental material, sj-docx-1-sgo-10.1177_21582440231199320 for Understanding Blockchain Technology Adoption in Operation and Supply Chain Management of Pakistan: Extending UTAUT Model With Technology Readiness, Technology Affinity and Trust by Qingyu Zhang, Salman Khan, Safeer Ullah Khan and Ikram Ullah Khan in SAGE Open</p

sj-jpg-4-hol-10.1177_09596836231183067 – Supplemental material for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India

Supplemental material, sj-jpg-4-hol-10.1177_09596836231183067 for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India by Anjum Farooqui, Salman Khan, Rajesh Agnihotri, Binita Phartiyal and Sunil Shukla in The Holocene</p

sj-docx-1-hol-10.1177_09596836231183067 – Supplemental material for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India

Supplemental material, sj-docx-1-hol-10.1177_09596836231183067 for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India by Anjum Farooqui, Salman Khan, Rajesh Agnihotri, Binita Phartiyal and Sunil Shukla in The Holocene</p

Engineering MPC-Assisted Heterojunctional Photo-Oxidation Tailored by Interfacial Design of a P‑Modulated C₃N₄ Heterojunction for Improved Aerobic Alcohol Oxidation

The creation of two-dimensional van der Waals (VDW) heterostructures is a sophisticated approach to enhancing photocatalytic efficiency. However, challenges in electron transfer at the interfaces often arise in these heterostructures due to the varied structures and energy barriers of the components involved. This study presents a novel method for constructing a VDW heterostructure by inserting a phosphate group between copper phthalocyanine (CuPc) and boron-doped, nitrogen-deficient graphitic carbon nitride (BCN), referred to as Cu/PO4-BCN. This phosphate group serves as a charge mediator, enabling effective charge transfer within the heterostructure, thus facilitating electron flow from BCN to CuPc upon activation. As a result, the photogenerated electrons are effectively utilized by the catalytic Cu2+ core in CuPc, achieving a conversion efficiency of 96% for benzyl alcohol (BA) and a selectivity of 98.8% for benzyl aldehyde (BAD) in the presence of oxygen as the sole oxidant and under illumination. Notably, the production rate of BAD is almost 8 times higher than that observed with BCN alone and remains stable over five cycles. The introduction of interfacial mediators to enhance electron transfer represents a pioneering and efficient strategy in the design of photocatalysts, enabling the proficient transformation of BA into valuable derivatives

sj-jpg-5-hol-10.1177_09596836231183067 – Supplemental material for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India

Supplemental material, sj-jpg-5-hol-10.1177_09596836231183067 for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India by Anjum Farooqui, Salman Khan, Rajesh Agnihotri, Binita Phartiyal and Sunil Shukla in The Holocene</p

Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity

The transmission of acetylcholine (ACh) is critically important for memory, learning, and behaviour. The most promising approaches for the treatment of cholinergic dysfunction involve the enhancement of ACh via nootropic phytomolecules. In the same line, the present study identifies the active molecule Bakuchiol derived from Psoralea corylifolia. Bakuchiol demonstrated significant elevation of ACh transmission, reduction of reactive oxygen species (ROS) levels, and extension of lifespan. Further investigation indicated that modulation of mRNA expression of genes encoding choline transporter, choline acetyltransferase, and acetylcholine transporter as possible effectors of amassed neural transmission. Moreover, Bakuchiol showed efficacy in reducing amyloid β and lipid levels, possibly through the upregulation of heat shock transcription factor 1 (hsf-1) and autophagy (lgg-1) genes. Overall, our findings establish the efficacy of Bakuchiol in modulating cholinergic dysfunction.</p

MOESM1 of Biaryl scaffold-focused virtual screening for anti-aggregatory and neuroprotective effects in Alzheimer’s disease

Additional file 1. The ids of compounds searched from zinc data base along with their binding affinities

sj-jpg-3-hol-10.1177_09596836231183067 – Supplemental material for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India

Supplemental material, sj-jpg-3-hol-10.1177_09596836231183067 for Monitoring hydroecology and climatic variability since ~4.6 ka from palynological, sedimentological and environmental perspectives in an Ox-bow lake, Central Ganga Plain, India by Anjum Farooqui, Salman Khan, Rajesh Agnihotri, Binita Phartiyal and Sunil Shukla in The Holocene</p

Supplementary file .docx from Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis

Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis, because of its easy administration, reduced systemic adverse effects and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation is being associated with severe dyspepsia and stomach pain. Herein, NTZ-transethosomes (NTZ-TES) were prepared and loaded into chitosan gel (NTZ-TEG) for topical delivery. NTZ-TES were prepared by thin-film hydration method and optimized statistically via Box-Behnken method. The optimized formulation indicated excellent particle size (176 nm), polydispersity index (0.093), zeta potential (−26.4 mV) and entrapment efficiency (86%). The transmission electron microscopy analysis showed spherical-sized particles and Fourier-transform infrared spectroscopy analysis indicated no interaction among the excipients. Similarly, NTZ-TEG showed optimal pH, desirable viscosity and good spreadability. NTZ-TES and NTZ-TEG showed prolonged release behaviour and higher skin penetration and deposition in epidermal/dermal layer of skin in comparison with the NTZ-dispersion. Moreover, NTZ-TES showed higher percentage inhibition, lower IC50 against promastigotes and higher macrophage uptake. Additionally, skin irritation and histopathology studies indicated the safe and non-irritant behaviour of the NTZ-TEG. The obtained findings suggested the enhanced skin permeation and improved anti-leishmanial effect of NTZ when administered as NTZ-TEG