The effect of unrestricted cycling KD on patient-derived IDH1^wt and IDH1^mut flank xenograft growth.

Tumor volumes for mice subcutaneously engrafted with IDH1mut GBM164 at 21 days, IDH1mut GBM 196 at 14 days, and IDH1wt GBM12 at 14 days, either on SD or cycling KD (initiated 3 days after engraftment). Time points differed due to differing rates of tumor growth. Bars = means, P values calculated by unpaired t-tests.</p

Effect of ketones on patient-derived IDH1^wt and IDH1^mut tumor cell proliferation <i>in vitro</i>.

Absolute cell counts over 14 days of culture in either normal glucose (NG) or low glucose (LG), with or without 10 mM β-hydroxybutyrate (BHB). Each data point is shown as mean ±SEM. Two-way ANOVA analyses of the final time points are described in the Results text and Table 3.</p

Basic metabolic parameters of mice on an unrestricted cycling KD.

Saphenous vein blood samples tested for glucose (A) and ketones (B) at the end of each week. Mouse body weights are shown in (C). Green bars indicate weeks in which mice were on KD.</p

Two-way ANOVA analyses of <i>in vitro</i> proliferation of IDH^wt and IDH^mut tumor cells in varying glucose and ketogenic culture conditions.

Two-way ANOVA analyses of in vitro proliferation of IDHwt and IDHmut tumor cells in varying glucose and ketogenic culture conditions.</p

Summary of cell lines used.

Summary of cell lines used.</p

Summary of macronutrient composition of standard and experimental diets presented as proportion of total kilocalories.

Summary of macronutrient composition of standard and experimental diets presented as proportion of total kilocalories.</p

Additional file 1 of The efficacy of DNA mismatch repair enzyme immunohistochemistry as a screening test for hypermutated gliomas

Additional file 1: Table S1. Detailed clinical and pathologic data for the full cohort of 100 gliomas. Tumors 1–9 are hypermutated and are also shown in Table S1. of the main manuscript. The following tumors are from the same patients: 1 and 2; 5, 11, and 12; 7 and 94. Pre-TMZ gliomas were designated as N/A in the TMZ dose and duration columns. Records on temozolomide dosage and cycles were incomplete for many post-TMZ patients, because they had been treated at outside institutions prior to re-resection at Northwestern. “D Astro” = diffuse astrocytoma; “A Astro” = anaplastic astrocytoma; “A Oligo” = anaplastic oligodendroglioma; N/A = not available or not applicable. Table S2. Correlation matrix. N = 93 tumors (cases without MGMT data were excluded, as well as hypermutated tumor #2 since it came from the same patient as tumor #1, see Fig. 2 and Additional file 1: Table S1). Each value represents Spearman ρ (rho) correlation coefficients, with 1 = perfect direct correlation, 0 = no correlation, and − 1 = perfect inverse correlation. *P < 0.05. TMZ = temozolomide

The effect of unrestricted cycling KD on patient-derived IDH1^wt and IDH1^mut intracranial xenograft growth.

Kaplan-Meier survival curves of mice engrafted with (A) IDH1wt NPA or (B) IDH1mut NPAC1, either on SD or cycling KD (initiated 3 days after engraftment).</p

Supplementary Tables 1-3 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

Clinico-pathological characteristics of PCa patiens selected for IHC and isolation of CAF. DEG genes between PrF-AA and PrF-EA</p

Supplementary Figure 4 from Elevation of Stromal-Derived Mediators of Inflammation Promote Prostate Cancer Progression in African-American Men

IHC staining and quantitation of FAP in AA andEA patient samples</p