Membran Alginat Sebagai Pembalut Luka Primer Dan Media Penyampaian Obat Topikal Untuk Luka Yang Terinfeksi

Alginat sampai saat ini belum dimanfaatkan untuk tekstil medis, terutama sebagai produk alternatif pembalut luka primer. Dari penelitian terdahulu diperoleh membran alginat berdaya serap tinggi, bersifat anti bakteri dan dapat mempercepat penyembuhan luka, namun bukan antibiotik. Penelitian ini adalah penelitian lanjutan yang bertujuan untuk membuat membran alginat yang mengandung obat (Basitrasin dan Neomisin), agar dihasilkan membran dengan kualitas lebih baik, karena dapat menyembuhkan luka yang terinfeksi. Oleh karenanya diperlukan penelitian lanjutan. Pengujian yang dilakukan meliputi uji fisika, analisa gugus fungsi dan struktur mikro serta uji pre klinis.Penelitian ini berhasil mendapatkan membran yang dapat mempercepat penyembuhan luka yang terinfeksi. Diharapkan, produk ini dapat digunakan untuk mensubstitusi kebutuhan pembalut luka impor. Dengan demikian, apabila bahan bakunya berasal dari sumber daya alam yang ada, maka selain akan lebih ekonomis lagi, diharapkan terciptanya diversifikasi produk yang mempunyai nilai tambah.Dari hasil uji ternyata kualitas produk dipengaruhi oleh kondisi proses. Semakin besar konsentrasi alginat, membran semakin kuat, berat dan tebal, namun mulurnya berkurang. Membran memenuhi beberapa kriteria sebagai pembalut luka dan media penyampaian obat topikal, yaitu berdaya absorpsi tinggi, berpori, memiliki sifat fisik yang memadai, dan dapat mempercepat penyembuhan luka yang terinfeksi

Effect of Chronic Toxicity Studies of Sappan Wood Extract on The Kupffer Cells Number in Rats (Rattus novergicus)

Sappan wood (Caesalpinia sappan L.) is a plant used by the community to mix drinking. The antioxidant index of Sappan wood extract has a higher value than commercial antioxidants to counteract oxidative free radicals and improve the body's defense system. The use of Sappan wood drinking in society is often used in daily so it is necessary to do a chronic toxicity test to observe the response to prolonged use of the system in the body. Kupffer cells are an important part of the innate immune system, acting as “scavengers” and phagocytes. A study that aims to see the chronic toxicity studies of the ethanolic extract of Sappan wood on the number of Kuffer cells in the liver has been carried out on 60 Wistar rats divided into 12 groups. The group was the negative control group, doses 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW and 500 mg/kgBW of extract Sappan wood which were divided into male and female groups. Each group was given ethanol extract of Sappan wood for one year orally. The results showed a significant increase in Kupffer cells in the female group at a dose of 100 mg/kgBW and the male group at 200 mg/kgBW with significant values, respectively, p<0.001 p = 0.004

Characterization of Bacillus megaterium and Bacillus mycoides Bacteria as Probiotic Bacteria in Fish and Shrimp Feed

This study was designed to identify probiotic characteristics and test the cellulolytic ability of Bacillus megaterium and Bacillus mycoides bacteria for probiotic microbe candidates in fish and shrimp feed. The identification of the cellulolytic and amylolytic abilities of these bacteria was obtained by non-experimental method and descriptive analysis. Results indicated that the maximum growth of B. megaterium was observed after six hours at 35.62 x 1010 (CFU), while B. mycoides was after 30 hours at 42.6 x 1010 (CFU). Macroscopic observation showed that the colony of B. megaterium was concave and smooth, while B. mycoides was flat, relatively rough, with silken threads around the colony. Both bacteria had a milky white color, bacillus shape, Gram positive, and sporous. The activity of cellulose and amylase enzymes in B. megaterium were 3,974 units/ml and 1,831 units/ml respectively. The activity of cellulose and amylase enzymes in B. mycoides were 3,506 units/ml and 3,730 units/ml respectively. This study concludes that both bacteria could be used in fish feed. Keywords: Characterization, Bacillus megaterium, Bacillus mycoides, probiotic microbes, feed

Alexander Technique To Reduce Lower Back Pain In 3rd Trimester of Pregnancy

Background  : Studies back pain due to pregnancy 25-90%, was estimated 50% of pregnant women experience back pain. As many as 80% of pregnant women said that back pain during pregnancy interfere with daily routines and 10% unable to work. The Alexander Technique exercises 65-72% effective in reducing back pain. Learning the Alexander technique have an impact on long-term reductions significantly to lower back pain. Research to determine the effectiveness of the Alexander Technique to the level of lower back pain in the third trimester pregnant mothers.Method : pre-experimental research with one group pretest posttest design. Population this study the third trimester pregnant women who experience lower back pain amounting to 31 people in Selopampang public health center Temanggung district. Collecting data used a pain scale observation sheet NRS (Numerical Rating Scale). Analyze data used Wilcoxon test.Result : research showed the Z value of -3.859. It showed that the Alexander technique is effective in reducing low back pain that is felt as much as 3x with Asymp. Sig. (2-tailed) 0.000, which means there is a difference low back pain before and after alexander technique intervention.Conclusion : the Alexander Technique could be an alternative to reduce lower back pain in 3rd trimester of pregnanc

Otomasi Sistem Rumah Anti Banjir dengan Notifikasi SMS

This flood disaster is caused directly by the rain with high intensity in a long time, and indirectly cause by garbage disposal in the river, There is no water catchment, flood from other river, etc. Therefore, we needed early warning sistem that provide information to people whos needed to save theirs homes, goods and ensuring safety for the residents of the house. With automation system of house unflood which is simulated using device such as hydraulic pumps, ultrasonic sensors and arduino uno to monitor the height of water or flood and associated with application, the goal of this research is helping people to reduce disaster losses from flood disaster programs and facilitate people with the automated technology used on this system. The case study on Jatikramat urban village because the floods in this area often happened. Application built using software Visual Studio 2008 and software database Ms.Access 2007. Conclusion of this research is implementation using Simulating a homestead with various device as a data input and connected to the application that we build to moving house using hydrolic during flood is successfully as well as with buzzer as alarm and SMS as notification

PENGARUH KECERDASAN VISUAL-SPASIAL DAN KREATIVITAS SISWA TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS

Penelitian ini bertujuan untuk mengetahui pengaruh kecerdasan visual spasial dan kreativitas siswa terhadap kemampuan pemecahan masalah matematis. Penelitian ini menggunakan metode kuantitatif. Populasi dalam penelitian ini adalah siswa kelas VIII SMPN 14 Tangerang yang berjumlah 328 siswa, dengan sampel sebanyak 77 siswa. Teknik pengumpulan data dengan menggunakan instrumen soal tes dan kuesioner. Untuk pengujian hipotesis penelitian ini menggunakan uji t, dari hasil uji t pada kecerdasan visual spasial diperoleh thitung = 1,994 dan ttabel = 1,666, maka dapat disimpulkan bahwa terdapat pengaruh kecerdasan visual spasial terhadap kemampuan pemecahan masalah matematis. Sedangkan untuk pengujian hipotesis kreativitas dari hasil uji t diperoleh thitung = 2,186 dan ttabel = 1,666, maka dapat disimpulkan bahwa terdapat pengaruh kreativitas siswa terhadap kemampuan pemecahan masalah matematis. Dan menggunakan uji F dengan hasil Fhitung = 14,412 dan Ftabel = 3,12.  Hal ini berarti bahwa secara simultan kecerdasan visual spasial dan kreativitas siswa mempengaruhi kemampuan pemecahan masalah matematis.

PENGGUNAAN MEMBRAN ALGINAT SEBAGAI PRODUK ALTERNATIF TEKSTIL MEDIS PEMBALUT LUKA PRIMER PADA KELINCI ALBINO JANTAN

Untuk mengetahui apakah membran alginat dapat digunakan sebagai produk alternatif tekstil medispembalut luka primer, maka telah dilakukan uji pre klinis untuk mengobati luka pada kulit kelinci albino jantan,sesuai dengan standar yang berlaku (OCDC Guidelines for the testing of Chemicals, 404). Percobaan dilakukanterhadap tiga ekor kelinci albino jantan, yaitu dengan melukai bagian kiri dan kanan punggung kelinci. Bagiankanan punggung kelinci ditempelkan pembalut luka yang kontak langsung dengan luka, sedangkan bagian kirinyatidak (sebagai kontrol). Adapun waktu pengamatannya adalah 1 jam, 24 jam, 48 jam dan 72 jam. Dari hasilpercobaan diketahui bahwa membran dapat mempercepat penyembuhan luka dan tidak menyebabkan iritasi kulit,bahkan setelah tiga hari hampir tidak terlihat adanya goresan bekas luka

EFFECT OF POWDER AND LIQUID PREPARATIONS OF PROBIOTICS ON WHITE SHRIMP (Litopenaeus vannamei) GROWTH PERFORMANCE

Indonesia is the second largest supplier of white shrimp (Litopenaeus vannamei, Boone 1931) in the USA market. Hence, the need for its sustainable production and improved growth. Probiotics, among others, are known for their growth enhancing attributes. Therefore, this study was conducted to determine the effects of powder and liquid probiotics on the growth of white shrimps at the Minaloka Jaya shrimp ponds, Grabag District, Purwerojo Regency, Central Java. The shrimps were cultivated for 60 days and applied with three probiotic treatments, namely commercial liquid probiotics with dosage of 10 mL/kg feed, powder probiotics with dosage of 10 g/kg feed and liquid probiotic with dosage of 10 mL/kg feed. Each probiotic preparation was administered four times a day to over 150,000 vannamei shrimps which were cultured in a semi-intensive system. Probiotics in powder and liquid forms contain Lactobacillus fermentum, L acidophilus, L. plantarum, L, curvatus, Bacillus licheniformis, B. subtilis, and B. polimyxa. B. megaterium, B. coagulans, Pseudomonasputida, Nitrosomonas sp. and Nitrobacter sp. Using the Randomized Block Design (RBD), the three treatments were replicated five times. The application of probiotics in both powder and liquid forms had increased the growth yield of the vannamei shrimp. However, the powder probiotic had shown better growth performance than the commercial liquid probiotics and liquid preparation of probiotics. Probiotic powder form provides a specific growth rate (SGR) of 8.18%, absolute body length of 9.68 cm, absolute biomass of 6.78 g, and feed conversion ratio (FCR) of 1.93

THE VIABILITY TEST OF SAPPAN WOOD (CAESALPINIA SAPPAN L.) ETHANOL EXTRACT IN THE H9C2 CELL LINE

Objective: In this study, the embryonic rat cardiomyocyte cell line H9C2 was used to investigate the cardiotoxicity effect of sappan wood ethanol extract (SWEE). Methods: Sappan wood was extracted in 96% ethanol and divided into dose concentrations of 2.5, 5, 10, 50, 100, and 150 μg/ml, with deferiprone used as a control. Cell viability was assessed using the PrestoBlue Cell Viability Reagent, according to manufacturer protocols. Results: Microscopic examination showed that the cell viability of H9C2 was preserved by SWEE treatments at a dose of 10 μg/ml and suggested dose concentrations of 50 μg/ml of SWEE. The percentage of viable cells was greater than 95% with a dose concentration of 10 μg/ml of SWEE, but it was significantly reduced with a dose concentration of 50 μg/ml of SWEE (p<0.05). Conclusion: The optimal dose concentration of SWEE to reach 95% cell viability was 10 μg/ml