18 research outputs found

    Graphs illustrating the model predictions of the effect of spatial heterogeneity given the baseline input values in Tables (1, 2, 3).

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    <p>The mean predicted numbers of appropriate treatments if a protocol based on the Vientiane epidemiology is applied nationally is plotted in Graph (a) for a range of values for national and regional variation. The 2.5% and 97.5% prediction intervals are plotted in Graphs (c) and (e). The mean additional numbers of appropriate treatments (i.e. the potential impact) predicted if a spatially explicit treatment protocol based on the incidence not only in Vientiane but also in three sentinel provinces were applied is plotted in Graph (b) for the same range of national and regional variation. The 2.5% and 97.5% prediction intervals are plotted in Graphs (c) and (f).</p

    Genes downregulated in melioidosis and tuberculosis, arranged by pathway.

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    <p>IFN = interferon, IGF = insulin-like growth factor, IL = interleukin, NF-κB = nuclear factor kappa-light-chain-enhancer of activated B cells, PI3K = phosphoinositide 3-kinase, RNA = ribonucleic acid, TGF = transforming growth factor, TNF = tumour necrosis factor.</p><p>Note:– Genes names are those assigned by the HUGO gene nomenclature committee.</p

    Patient characteristics.

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    a<p>One patient in this group was lost to follow-up following discharge from hospital, and was counted as having survived to discharge.</p><p>Gb = Glibenclamide. Values reported are means, except where stated.</p

    Interferon signatures for melioidosis and tuberculosis.

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    <p>Note: The interferon signatures for melioidosis (<b>A</b>) and tuberculosis (<b>B</b>) are listed here (analysis from <a href="http://www.interferome.org" target="_blank">www.interferome.org</a>). Berry <i>et al.</i> noted that both type 1 and type 2 interferon responses were prominent in tuberculosis. We find that type 1 interferon responses appear in melioidosis also.</p
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