648 research outputs found
“It Would be Harder Without Faith”: An Exploratory Study of Low-Income Families’ Experiences of Early Childhood Inclusive Education in New Zealand
New Zealand has a reputation for having one of the most inclusive education systems in the world. However, research and anecdotal evidence show that many parents of young children with disabilities have difficulties accessing intervention and health-care services and may be less satisfied when they do receive services. In addition, though a plethora of research has been done on inclusive education, little attention has been given by researchers to low-income parents’ perspectives on early childhood inclusion in New Zealand. This paper draws on findings from a qualitative study on 30 parents’ experiences of early childhood inclusive education in New Zealand. Parents participating in this study came from different religious back-grounds, represented diverse ethnicities, all had at least one child who had a diagnosis of disabilities and/or chronical illness, and met the low-income criteria of New Zealand. Results showed that though the majority of the families appreciated the flexible time and structures of the early childhood programs their children attended, parents were concerned about the lack of intervention services for their children. In addition, these low-income families reported that they had limited access to early interventions and resources. The findings also highlight the importance of the use of positive coping methods (e.g., maintaining a positive outlook and seeking social support), and the role faith plays in family life.</p
“It Would be Harder Without Faith”: An Exploratory Study of Low-Income Families’ Experiences of Early Childhood Inclusive Education in New Zealand
New Zealand has a reputation for having one of the most inclusive education systems in the world. However, research and anecdotal evidence show that many parents of young children with disabilities have difficulties accessing intervention and health-care services and may be less satisfied when they do receive services. In addition, though a plethora of research has been done on inclusive education, little attention has been given by researchers to low-income parents’ perspectives on early childhood inclusion in New Zealand. This paper draws on findings from a qualitative study on 30 parents’ experiences of early childhood inclusive education in New Zealand. Parents participating in this study came from different religious back-grounds, represented diverse ethnicities, all had at least one child who had a diagnosis of disabilities and/or chronical illness, and met the low-income criteria of New Zealand. Results showed that though the majority of the families appreciated the flexible time and structures of the early childhood programs their children attended, parents were concerned about the lack of intervention services for their children. In addition, these low-income families reported that they had limited access to early interventions and resources. The findings also highlight the importance of the use of positive coping methods (e.g., maintaining a positive outlook and seeking social support), and the role faith plays in family life.</p
sj-pdf-2-imr-10.1177_03000605211047779 - Supplemental material for A rare case of type II negative pressure pulmonary edema following extraction of inhaled peanuts in a 21-month-old boy
Supplemental material, sj-pdf-2-imr-10.1177_03000605211047779 for A rare case of type II negative pressure pulmonary edema following extraction of inhaled peanuts in a 21-month-old boy by Qin Li and Liang Zhou in Journal of International Medical Research</p
sj-pdf-1-imr-10.1177_03000605211047779 - Supplemental material for A rare case of type II negative pressure pulmonary edema following extraction of inhaled peanuts in a 21-month-old boy
Supplemental material, sj-pdf-1-imr-10.1177_03000605211047779 for A rare case of type II negative pressure pulmonary edema following extraction of inhaled peanuts in a 21-month-old boy by Qin Li and Liang Zhou in Journal of International Medical Research</p
Tunable Two-Dimensional Array Patterning of Antibody Annuli through Microsphere Templating
Protein microarrays are of great research interest because of their potential application as biosensors for high-throughput protein and pathogen screening technologies. In this active area, there is a lack of techniques that can result in annulus-shaped protein structures (e.g., for the utilization of curved surfaces for enhanced protein−protein interactions and the detection of antigens). We present a new technique employing colloidal templating to yield large-scale (∼cm2) 2D arrays of antibodies against Escherichia coli K12 and enhanced green fluorescent protein (eGFP) on a versatile glass surface. The antibodies are swept to reside around the templating microspheres during solution drying and physically adsorb onto the glass. After the microspheres are removed, an array of annulus-shaped antibody structures is formed. We demonstrate the preserved antibody structure and functionality by binding the specific antigens and secondary antibodies, respectively, which paves the way for the binding of biomolecules and pathogens such as bacteria and viruses. The structures were investigated via atomic force, confocal, and fluorescence microscopy. Operational factors such as the drying time, temperature, and humidity as well as the presence of surfactants in the antibody solution were tuned to obtain a stable antibody structure
Tunable Two-Dimensional Array Patterning of Antibody Annuli through Microsphere Templating
Protein microarrays are of great research interest because of their potential application as biosensors for high-throughput protein and pathogen screening technologies. In this active area, there is a lack of techniques that can result in annulus-shaped protein structures (e.g., for the utilization of curved surfaces for enhanced protein−protein interactions and the detection of antigens). We present a new technique employing colloidal templating to yield large-scale (∼cm2) 2D arrays of antibodies against Escherichia coli K12 and enhanced green fluorescent protein (eGFP) on a versatile glass surface. The antibodies are swept to reside around the templating microspheres during solution drying and physically adsorb onto the glass. After the microspheres are removed, an array of annulus-shaped antibody structures is formed. We demonstrate the preserved antibody structure and functionality by binding the specific antigens and secondary antibodies, respectively, which paves the way for the binding of biomolecules and pathogens such as bacteria and viruses. The structures were investigated via atomic force, confocal, and fluorescence microscopy. Operational factors such as the drying time, temperature, and humidity as well as the presence of surfactants in the antibody solution were tuned to obtain a stable antibody structure
Supplementary document for Scintillation Minimization versus Intensity Maximization in Optimal Beams - 6478735.pdf
Supplementary material
EAE869390 Supplemental Material4 - Supplemental material for Are there industrial SO<sub>2</sub> convergences in China’s prefecture-level cities? New evidence from a spatial econometric perspective
Supplemental material, EAE869390 Supplemental Material4 for Are there industrial SO2 convergences in China’s prefecture-level cities? New evidence from a spatial econometric perspective by Yongqing Nan, Qin Li, Haiya Cai and Zhou Qin in Energy & Environment</p
DataSheet_1_KRT17 from skin cells with high glucose stimulation promotes keratinocytes proliferation and migration.xlsx
Impaired diabetic wound healing is an important issue in diabetic complications. Proliferation and migration of keratinocytes are major processes of skin wound repair after injury. However, hyperkeratosis can affect the speed of wound healing. Based on the results of preliminary experiments on increased KRT17 expression after high glucose stimulation of human skin tissue cells, a cell model of human immortalized keratinocyte (HaCaT) stimulation with different concentrations of KRT17 was established in vitro, and the promotion in cell proliferation and migration were discovered. KRT17 silencing promoted diabetic wound healing in the db/db diabetic wound model. Transcriptome sequencing (RNA-seq) was performed on HaCaT cells after KRT17 stimulation, and analysis showed significant enrichment in the PI3K-AKT signaling pathway, in which the regulation of cell c-MYB mRNA, a key molecule regulating cell proliferation and migration, was significantly upregulated. In vitro assays showed increased c-MYB expression and enhanced pAKT activity after HaCaT cell stimulation by KRT17. We speculate that KRT17 is upregulated under high glucose and promotes keratinocyte proliferation and migration caused hyperkeratosis, through the c-MYB/PI3K-AKT pathway, contributing to delayed wound healing.</p
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