Presentation_1_Measuring the Psychological Security of Urban Residents: Construction and Validation of a New Scale.pdf

With the acceleration of urbanization in developing countries, resources relating to medical care and the environment are becoming increasingly scarce, and the negative spillover effects brought about by scientific and technological progress have also significantly increased the pressure on urban residents. The psychological security of urban residents has recently undergone significant change. This paper introduces psychological security into the area of urban residents’ lives, defines the concept of urban residents’ psychological security, and presents the development and validation of the Urban Residents Psychological Security Scale (URPS). By considering psychological indicators, this paper supplements our knowledge on environmental indicators such as the risk perception of environmental pollution and climate change, and social indicators such as urban belongingness and the risk perception of technology which verifies the negative spillover effects of technological development. Based on a literature search and consideration of grounded theory (25 urban residents’ in-depth interview records), the psychological security of urban residents is divided into three dimensions: self-psychological security, social environmental security, and natural environmental security, consisting of 20 items. In this study, 802 questionnaires were completed by participants. We determined that the URPS scale has good reliability and validity using exploratory factor analysis and confirmatory factor analysis, and conclude that the scale can be used as an effective measurement tool for urban residents’ psychological security. The development of this scale has important theoretical and practical significance in helping city managers better understand the residents’ demands and to monitor the implementation effects of policies.</p

MicroRNA-98-5p Inhibits IFI44L-Mediated Differentiation of Dendritic Cells and Activation of Interferon Pathway in Systemic Lupus Erythematosus

MicroRNA-98-5p (miR-98-5p) plays a protective role in the pathogenesis of autoimmune diseases through anti-inflammatory effects, but little is known about its role in Systemic lupus erythematosus (SLE). Our previous study suggested Interferon-inducible 44 like (IFI44L) overexpressed in monocytes which contributes to the pathogenesis of SLE by enhancing the maturation and functions of monocyte-derived dendritic cells (Mo-DCs), and miR-98-5p can regulate the expression of IFI44L. In this study, we identified miR-98-5p lowly expressed in both peripheral blood mononuclear cells (PBMCs) and monocytes of SLE patients along with high expression of IFI44L. IFI44L serves as target gene of miR-98-5p which inhibits differentiation of Mo-DCs and IFI44L-mediated activation of interferon pathway. We further showed that miR-98-5p promotes methylation of the IFI44L promoter to down-regulate its expression in SLE. Our results reveal an important role for miR-98-5p in the IFI44L-mediated immune imbalance of SLE and suggest a potential therapeutic target for SLE in the future.</p

Efficient Direct X‑ray Detection and Imaging Based on a Lead-Free Electron Donor–Acceptor MOF

Metal–organic frameworks (MOFs) have recently gained extensive attention as potential materials for direct radiation detection due to their strong radiation absorption, long-range order, and chemical tunability. However, it remains challenging to develop a practical MOF-based X-ray direct detector that possesses high X-ray detection efficiency, radiation stability, and environmental friendliness. The integration of donor–acceptor (D–A) pairs into crystalline MOFs is a powerful strategy for the precise fabrication of multifunctional materials with unique optoelectronic properties. Herein, a new lead-free MOF, Cu2I2(TPPA) (CuI-TPPA, TPPA = tris[4-(pyridine-4-yl)phenyl]amine), with a 6-fold interpenetrated structure is designed and synthesized based on the electron donor–acceptor strategy. CuI-TPPA has a large mobility-lifetime (μτ) product of 5.8 × 10–4 cm2 V–1 and a high detection sensitivity of 73.1 μC Gyair–1 cm–2, surpassing that of commercial α-Se detectors. Moreover, the detector remains fairly stable with only a 2% reduction in photocurrent under continuous bias irradiation conditions with a total dose of over 42.83 Gyair. The CuI-TPPA/poly(vinylidene fluoride) flexible composite X-ray detector films are successfully manufactured with different thicknesses. Through multifaceted assessments, the optimal thickness is found with a high detection sensitivity of up to 143.6 μC Gyair–1 cm–2. As proof-of-concept, 11 × 9 pixelated X-ray detectors are fabricated on the same composite film to realize X-ray direct imaging. This work opens up potential applications of MOFs in environmentally friendly and wearable devices for direct X-ray detection and imaging

Efficient Direct X‑ray Detection and Imaging Based on a Lead-Free Electron Donor–Acceptor MOF

Metal–organic frameworks (MOFs) have recently gained extensive attention as potential materials for direct radiation detection due to their strong radiation absorption, long-range order, and chemical tunability. However, it remains challenging to develop a practical MOF-based X-ray direct detector that possesses high X-ray detection efficiency, radiation stability, and environmental friendliness. The integration of donor–acceptor (D–A) pairs into crystalline MOFs is a powerful strategy for the precise fabrication of multifunctional materials with unique optoelectronic properties. Herein, a new lead-free MOF, Cu2I2(TPPA) (CuI-TPPA, TPPA = tris[4-(pyridine-4-yl)phenyl]amine), with a 6-fold interpenetrated structure is designed and synthesized based on the electron donor–acceptor strategy. CuI-TPPA has a large mobility-lifetime (μτ) product of 5.8 × 10–4 cm2 V–1 and a high detection sensitivity of 73.1 μC Gyair–1 cm–2, surpassing that of commercial α-Se detectors. Moreover, the detector remains fairly stable with only a 2% reduction in photocurrent under continuous bias irradiation conditions with a total dose of over 42.83 Gyair. The CuI-TPPA/poly(vinylidene fluoride) flexible composite X-ray detector films are successfully manufactured with different thicknesses. Through multifaceted assessments, the optimal thickness is found with a high detection sensitivity of up to 143.6 μC Gyair–1 cm–2. As proof-of-concept, 11 × 9 pixelated X-ray detectors are fabricated on the same composite film to realize X-ray direct imaging. This work opens up potential applications of MOFs in environmentally friendly and wearable devices for direct X-ray detection and imaging

Some key variants identified in analysis.

Some key variants identified in analysis.</p

Supplemental Material - Tight correlation of 5-hydroxymethylcytosine expression with the scarring damage of discoid lupus erythematosus

Supplemental Material for Tight correlation of 5-hydroxymethylcytosine expression with the scarring damage of discoid lupus erythematosus by Qianwen Li, Ming Yang, Kaili Chen, Suqing Zhou, Shengnan Zhou, and Haijing Wu in Lupus</p

Manhattan plots.

A. Results of pure meta-analysis, which includes 29 studies on PD. B. Results of mixed meta-analysis, which includes 59 studies on PD, inflammatory bowel disease (including its two subtypes: Crohn’s disease and ulcerative colitis), multiple sclerosis, and systemic sclerosis. lg ABF: log10ABF.</p

The comparison in accuracy and speed of the three algorithms under different iterations.

The comparison in accuracy and speed of the three algorithms under different iterations.</p

Image_1_Beyond the Motor Cortex: Thalamic Iron Deposition Accounts for Disease Severity in Amyotrophic Lateral Sclerosis.pdf

ObjectivePrevious studies have reliably identified iron deposition in the motor cortex as potential pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we intended to investigate iron deposition, gray matter (GM) atrophy, and their associations with disease severity in the motor cortex and the thalamus in patients with ALS.MethodsA total of 34 patients with ALS (age 51.31 ± 8.24 years, 23 males) and 34 nonneurological controls (age 50.96 ± 9.35 years, 19 males) were enrolled between 2018 and 2020. The Revised ALS Functional Rating Scale (ALSFRS-R) and the Penn upper motor neuron (UMN) score were measured. MRI data included quantitative susceptibility mapping (QSM) for iron deposition and three-dimensional (3D) T1 for gray matter volume. After a between-group comparison, Pearson's correlation coefficient was used for identifying correlations of iron deposition, GM volume, and clinical measurements.ResultsThe two-sample t-tests revealed increased iron deposition in the left precentral gyrus (peak voxel T = 4.78, PSVC = 0.03) and the thalamus (peak voxel: right: T = 6.38, PSVC SVC = 0.02) in patients with ALS. GM volume of the precentral gyrus (T = −2.42, P = 0.02) and the bilateral thalamus (T = −4.10, P DiscussionIron deposition in the thalamus, in addition to the motor cortex, is accompanied by GM atrophy and is associated with disease severity in patients with ALS, indicating that the thalamus is also a pathological region in patients with ALS.</p

The information of studies on PD included in the application.

The information of studies on PD included in the application.</p