Direct Access to Acylated Azobenzenes via Pd-Catalyzed C–H Functionalization and Further Transformation into an Indazole Backbone

Azobenzenes were readily acylated at the 2-position through a Pd-catalyzed C–H functionalization from simple aromatic azo compounds and aldehydes in good yields. The obtained acylated azobenzenes could be efficiently converted into the corresponding indazole derivatives in nearly quantitative yields

Photo-Driven Synthesis of C6-Polyfunctionalized Phenanthridines from Three-Component Reactions of Isocyanides, Alkynes, and Sulfinic Acids by Electron Donor–Acceptor Complex

A novel and efficient photoinduced synthesis of C6-polyfunctionalized phenanthridines from three-component reactions of isocyanides, alkynes and sulfinic acids was developed. The reactions generated the corresponding products with high selectivity through the photochemical activity of the formed electron donor–acceptor (EDA) complex during the reaction via a radical tandem process under mild conditions

Iron-Promoted Tandem Reaction of Anilines with Styrene Oxides via C–C Cleavage for the Synthesis of Quinolines

A novel iron-promoted tandem reaction of anilines with styrene oxides via C–C cleavage and C–H activation has been developed. The reaction utilizes an inexpensive FeCl3 as promoter and is suitable for forming a variety of 3-arylquinolines from the simple and readily available starting materials

A Sulfenylation Reaction: Direct Synthesis of 3‑Aryl­sulfinyl­indoles from Arylsulfinic Acids and Indoles in Water

A novel and efficient electrophilic sulfenylation of indoles with arylsulfinic acids is realized. The reaction utilizes readily available starting materials in water under catalyst- and additive-free conditions, providing an alternative and attractive approach to 3-arylsulfinylindoles with high yields. Preliminary mechanistic investigation suggested that the reaction is through an electrophilic substitution process

Direct Synthesis of Benzo[<i>f</i>]indazoles from Sulfonyl Hydrazines and 1,3-Enynes by Copper-Catalyzed Annulation

A novel and efficient strategy for the direct synthesis of benzo­[f]­indazoles via copper-catalyzed cascade reaction of sulfonyl hydrazides with 1,3-enynes under mild conditions has been developed. This method achieves the formation of two C–N bonds and one C–C bond in one pot, providing a series of benzo­[f]­indazoles in moderate to good yields with good functional group tolerance and remarkable regioselectivity

Palladium-Catalyzed Oxidative Cyclization of 3-Phenoxyacrylates: An Approach To Construct Substituted Benzofurans from Phenols

In this paper, a novel and applicable synthesis of benzofurans from commercially available phenols and propiolate through the direct oxidative cyclization has been developed. In the presence of Pd(OAc)2/PPh3 and CF3CO2Ag, (E)-type 3-phenoxyacrylates underwent reaction smoothly to generate the corresponding benzofurans in good yields in benzene at 110 °C under the air pressure. In addition, this transformation of phenols into benzofurans can also be carried out in one pot. The process was simple and efficient. A tentative mechanism of palladium-catalyzed oxidative cyclization of 3-phenoxyacrylates was proposed

Visible-Light Photoredox Catalyzed Three-Component Cyclization of 2<i>H</i>‑Azirines, Alkynyl Bromides, and Molecular Oxygen to Oxazole Skeleton

A novel three-component cyclization of 2<i>H</i>-azirines, alkynyl bromides, and molecular oxygen under visible-light photoredox catalysis at room temperature has been developed, which provides a direct approach to a wide range of substituted oxazoles in moderate to good yields

Merging Photoredox with Palladium Catalysis: Decarboxylative <i>ortho</i>-Acylation of Acetanilides with α‑Oxocarboxylic Acids under Mild Reaction Conditions

A room temperature decarboxylative <i>ortho</i>-acylation of acetanilides with α-oxocarboxylic acids has been developed via a novel Eosin Y with Pd dual catalytic system. This dual catalytic reaction shows a broad substrate scope and good functional group tolerance, and an array of <i>ortho</i>-acylacetanilides can be afforded in high yields under mild conditions

H₂O₂‑Promoted Reactions of Aliphatic Primary Amines with 1,3-Diketones for the Synthesis of 1<i>H</i>‑Pyrrol-3(2<i>H</i>)‑ones at Ambient Temperature in Water

A green organic reaction of aliphatic primary amines with 1,3-diketones promoted by 30% aqueous H₂O₂ has been developed. It provides an inexpensive, regioselective, and efficient approach to 1<i>H</i>-pyrrol-3­(2<i>H</i>)-ones with high yields from the simple and readily available starting materials in one pot via multicomponent tandem cyclization reactions and C–C cleavage under very mild and environmentally friendly reaction conditions