7,206 research outputs found

    Factors affecting the formation of FWUCs in institution building for PIMD in Cambodia: Two case studies

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    Irrigation programs / Participatory management / Farmer participation / Income / Institution building / Legal aspects / History

    Improving agricultural productivity for poverty alleviation through integrated service provision with public-private sector partnerships: Examples and issues

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    Irrigation management / Crop production / Productivity / Constraints / Poverty / Farmers’ associations / Public sector / Private sector / Models / Food security / Sugarcane / Rice

    Developing effective institutions for water resources management: A case study in the Deduru Oya Basin, Sri Lanka

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    River basins / Water resource management / Water lifting / Wells / Domestic water / Population / Economic aspects / Income / Irrigation programs / Institutions / Policy / Groundwater / Agricultural development / Fish farming / Pumps / Ecology / Water supply / Drought / Poverty / Land use / Water scarcity / Natural resources / Agricultural production / Cropping systems

    Constraints on the Inner Regions of Lensing Galaxies from Central Images using a Recent AGN Offset Distribution

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    In gravitational lensing, central images in quads can serve as a powerful probe of the inner regions of lens galaxies. The presence of an offset central supermassive black hole (SMBH) has the potential to distort the time-delay surface in a way such that 3 central images form: a strongly de-magnified image near the SMBH, and two less de-magnified (and potentially observable) images at a central maximum and saddle point. Using a quad lens macro model, we simulate the constraints that could be placed on various lens galaxy parameters based on their central images probability of detection or non-detection. Informed by a recent low-redshift distribution of off-nucleus AGN, we utilize Bayesian inference to constrain the mean SMBH off-nucleus distance and galactic core radius for a sample of 6 quads. In general, we find that a detection of the central image in any quad would favor larger SMBH off-nucleus distances and galaxy core sizes. Assuming a linear relationship between core radii and velocity dispersion rc=bσr_c = b\sigma, these results similarly imply strong constraints on bb, where the likely case of a central image non-detection in each quad constraining bb to 3.11−2.26+2.72×10−43.11^{+2.72}_{-2.26} \times 10^{-4} kpc km−1^{-1} s. Our results show that tight constraints on lens galaxy parameters can be made regardless of a detection or non-detection of a central image. Therefore, we recommend observational searches for the central image, possibly using our suggested novel detection technique in UV filters, to formalize stronger constraints on lens galaxy parameters.Comment: MNRAS, Accepted, 20 pages, 15 figure

    Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer

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    Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose.Methods:Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using 99 Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.Results:Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1±8.9 vs 31.3±12.9 mg (P=0.01). Both, AUC 24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P<0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P=0.03) in tumour specimens.Conclusion:Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.Fil: Sarduy, M. R.. Medical-surgical Research Center; CubaFil: García, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Coca, M. A.. Clinical Investigation Center; CubaFil: Perera, A.. Clinical Investigation Center; CubaFil: Torres, L. A.. Clinical Investigation Center; CubaFil: Valenzuela, C. M.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Baladrón, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Solares, M.. Hospital Materno Ramón Gonzålez Coro; CubaFil: Reyes, V.. Center For Genetic Engineering And Biotechnology Havana; CubaFil: Hernåndez, I.. Isotope Center; CubaFil: Perera, Y.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Martínez, Y. M.. Medical-surgical Research Center; CubaFil: Molina, L.. Medical-surgical Research Center; CubaFil: Gonzålez, Y. M.. Medical-surgical Research Center; CubaFil: Ancízar, J. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Prats, A.. Clinical Investigation Center; CubaFil: Gonzålez, L.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Casacó, C. A.. Clinical Investigation Center; CubaFil: Acevedo, B. E.. Centro de Ingeniería Genética y Biotecnología; CubaFil: López Saura, P. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; ArgentinaFil: Gómez, R.. Elea Laboratories; ArgentinaFil: Perea Rodríguez, S. E.. Center For Genetic Engineering And Biotechnology Havana; Cuba. Centro de Ingeniería Genética y Biotecnología; Cub

    Paid employment and common mental disorders in 50–64-year olds: analysis of three cross-sectional nationally representative survey samples in 1993, 2000 and 2007

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    Associations between employment status and mental health are well recognised, but evidence is sparse on the relationship between paid employment and mental health in the years running up to statutory retirement ages using robust mental health measures. In addition, there has been no investigation into the stability over time in this relationship: an important consideration if survey findings are used to inform future policy. The aim of this study is to investigate the association between employment status and common mental disorder (CMD) in 50–64-year old residents in England and its stability over time, taking advantage of three national mental health surveys carried out over a 14-year period. Data were analysed from the British National Surveys of Psychiatric Morbidity of 1993, 2000 and 2007. Paid employment status was the primary exposure of interest and CMD the primary outcome – both ascertained identically in all three surveys (CMD from the revised Clinical Interview Schedule). Multivariable logistic regression models were used. The prevalence of CMD was higher in people not in paid employment across all survey years; however, this association was only present for non-employment related to poor health as an outcome and was not apparent in those citing other reasons for non-employment. Odds ratios for the association between non-employment due to ill health and CMD were 3.05 in 1993, 3.56 in 2000, and 2.80 in 2007, after adjustment for age, gender, marital status, education, social class, housing tenure, financial difficulties, smoking status, recent physical health consultation and activities of daily living impairment. The prevalence of CMD was higher in people not in paid employment for health reasons, but was not associated with non-employment for other reasons. Associations had been relatively stable in strength from 1993 to 2007 in those three cross-sectional nationally representative samples

    Free-form and hybrid lens models for SDSS J1004+4112: substructure and central image time delay constraints

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    SDSS J1004+4112 is a well-studied gravitational lens with a recently measured time delay between its first and fourth arriving quasar images. Using this new constraint, we present updated free-form lens reconstructions using the lens inversion method grale, which only uses multiple image and time delay data as inputs. In addition, we obtain hybrid lens reconstructions by including a model of the brightest cluster galaxy as a Sersic lens. For both reconstructions, we use two sets of images as input: one with all identified images, and the other a revised set leaving out images that have been potentially misidentified. We also develop a source position optimization Markov chain Monte Carlo (MCMC) routine, performed on completed grale runs, that allows each model to better match observed image positions and time delays. All the reconstructions produce similar mass distributions, with the hybrid models finding a steeper profile in the centre. Similarly, all the mass distributions are fitted by the Navarro–Frenk–White profile, finding results consistent with previous parametric reconstructions and those derived from Chandra X-ray observations. We identify an ∌5 × 1011 M⊙ substructure apparently unaffiliated with any cluster member galaxy and present in all our models, and study its reality. Using our free-form and hybrid models, we predict a central quasar image time delay of ∌2980 ± 270 and ∌3280 ± 215 d, respectively. A potential future measurement of this time delay will, while being an observational challenge, further constrain the steepness of the central density profile