Estimated hazard of mortality due to carrying a <i>BRCA</i> mutation in the absence of any cancer¹.

1<p>Follow-up time and deaths were censored at first report of any cancer.</p

Estimated cumulative risk of mortality in the absence of any cancer.

<p>The figure shows the estimated cumulative risk of mortality in the absence of any cancer among females (panel A) and males (panel B).</p

Relative risks (RR) and 95% confidence intervals for total mortality by categories of body mass index in non-Hispanic blacks.

a.<p>Subjects who did not have any prevalent cancer except non-melanoma skin cancer or heart disease at baseline.</p>b.<p>Per 100,000 person-years, directly standardized to the age distribution of the cohort according to sex.</p>c.<p>Adjusted for age, sex, education (less than high school, high school graduate, some college, and college graduate/postgraduate), marital status (married and not married), smoking status (never, former, current), time since quitting smoking (never, stopped ≥10 years ago, stopped 5–9 years ago, stopped 1–4 years ago, stopped <1 year ago, and currently smoking), number of cigarettes per day (0, 1–10, 11–20, 21–30, 31–40, 41–50, 51–60, and >60 cigarettes/day), physical activity (never/rare, ≤3 times/mo, and 1–2 and ≥3 times/wk), alcohol consumption (0, >0–<15, 15–<30, and ≥30 g/day) and menopausal hormone therapy use in women (never, ever). In analysis of men and women, sex was excluded from the list of covariates.</p>d.<p>Adjusted for same covariates as noted in footnote c, except smoking status, time since quitting, and number of cigarettes per day. In analysis of men and women separately, sex was excluded from the list of covariates.</p

Estimated hazard of mortality due to carrying a <i>BRCA</i> mutation in the absence of melanoma and cancer of the breast, ovary, pancreas, and prostate¹.

1<p>Follow-up time and deaths were censored at first report of melanoma or cancer of the breast, ovary, pancreas, or prostate.</p

Relative risks (RR) and 95% confidence intervals for cause-specific deaths in non-Hispanic black never smokers ^a.

a.<p>Never smokers who did not have any prevalent cancer except non-melanoma skin cancer or heart disease at baseline.</p>b.<p>Adjusted for age, sex, education (less than high school, high school graduate, some college, and college graduate/postgraduate), marital status (married and not married), physical activity (never/rare, ≤3 times/mo, and 1–2 and ≥3 times/wk), alcohol consumption (0, >0–<15, 15–<30, and ≥30 g/day) and menopausal hormone therapy use in women (never, ever).</p

Cumulative incidence of mortality risk in the absence of established <i>BRCA</i> mutation-associated cancers.

<p>Estimated cumulative risk of mortality among females in the absence of breast, ovarian, pancreatic cancer, and melanoma is shown in panel A. Panel B shows the estimated cumulative risk of mortality among males in the absence of melanoma, prostate, and pancreatic cancer.</p

Relative risk for total mortality per 5-unit increase in body mass index in non-Hispanic blacks, according to selected characteristics^{a, b, c}.

<p>a. Subjects who did not have any prevalent cancer except non-melanoma skin cancer or heart disease at baseline. b. Adjusted for following variables, except for the stratification variable in each analysis: age, sex, education, marital status, smoking status, time since quitting smoking, number of cigarettes per day, physical activity, alcohol consumption, and menopausal hormone therapy use in women. c. Markers indicate the relative risks and horizontal lines indicate 95% confidence intervals. d. Number of death; p value for interaction: 0.55 for sex, 0.50 for age at baseline, <0.001 for smoking, 0.75 for physical activity, 0.40 for education, and 0.13 for alcohol.</p

Relative risk for total mortality in non-Hispanic black men and women^{a, b, c}.

<p>a. Subjects who did not have any prevalent cancer except non-melanoma skin cancer or heart disease at baseline b. Adjusted for age, education, marital status, smoking status, time since quitting smoking, number of cigarettes per day, physical activity, alcohol consumption, and menopausal hormone therapy use in women. Analysis of never smokers with no history of diseases at baseline was adjusted for same covariates except smoking status, time since quitting smoking, number of cigarettes per day. c. Men, 1,347 deaths in subjects with no history of disease and 288 deaths in never smokers with no history of diseases: Women, 1,262 deaths in subjects with no history of disease and 425 deaths in never smokers with no history of diseases.</p

Association of 10 SNPs on 9p22 with abnormal TVU screening results.

<p>Per allele odds ratios obtained with an additive model restricted to the Caucasian population for the association of 9p22 SNPs with abnormal screening results are shown. Cases are women with suspicious screening results; controls are women with normal or non-suspicious screening results. Worst TVU results indicate abnormal TVU results at any screen during the 4-year follow-up. First TVU results indicate abnormal TVU results at the first screen a woman participated in. Incident TVU results are abnormal results among women that were normal or non-suspicious at the first screening. An asterisk indicates p-values lower than 0.005, the significance level after conservative Bonferroni correction.</p

LD-plot of 10 SNPs on 9p22 from individuals included in the analysis.

<p>The LD-plot was generated with Haploview based on r² of the 10 SNPs on 9p22 in 992 Caucasian women with genotyping information and transvaginal ultrasound results available.</p