3 research outputs found

    Primary Central Nervous System Lymphoma: Focus on Indian Perspective

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    Early suspicion, withholding steroids, stereotactic biopsy, and high-dose methotrexate (HD-MTX) are essential for the treatment of primary CNS lymphoma (PCNSL) making its management in lower-middle-income countries (LMIC) challenging. Novel radiological methods, clinician awareness about the disease, and utilization of drugs like thiotepa and ibrutinib which can be given on an outpatient basis may allow better management of these patients in resource-poor settings. Combined with a late presenting demographic, this results in poorer outcomes in the Indian subcontinent as compared to its western counterparts. In this review, we summarize the currently available data on PCNSL in the Indian subcontinent. We also review the current standard of care for PCNSL and present potential modifications or research areas that may potentially improve outcomes in LMIC

    Bioinspired aluminum composite reinforced with soft polymers with enhanced strength and plasticity

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    Composites have played a key role in revolutionizing the automobile, marine, and aerospace industries. There is a constant attempt for the development of low‐density composite materials with superior mechanical and corrosion‐resistant properties for elevated temperature applications. Herein, an attempt is made to develop a nature‐inspired unique aluminum‐based composite with low‐density polymer (polyethylene terephthalate, i.e., soft material) reinforcement, which shows an enhancement in strength and toughness. The composite is processed using the easily scalable and simple friction stir processing technique. Mechanical properties of the uniformly reinforced aluminum composite show double ultimate strength and fivefold improvement in plasticity. The ultimate strength of the composite increases at elevated temperatures. The experimental observations are further supported by theoretical calculations and molecular dynamics simulations223CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPNão temNão tem2016/18499-0; 2019/07157-9; 2013/08293-7A.R., A.G., P.P. contributed equally to this work. E.F.O. would like to thank the Brazilian agency FAPESP (grants 2016/18499 0 and 2019/07157 9) for financial support. Computational and financial support from the Center for Computational Engineering and Sciences at Unicamp through the FAPESP/CEPID grant no. 2013/08293 7 is also acknowledged. D.S.G. also acknowledges support from CAPES and CNPq. Some of the authors would like to thank the Board of Research in Nuclear Sciences (BRNS) (project no.: 57/14/05/2019-BRNS) for the financial support. C.S.T. was thankful for the support by AOARD grant no. FA2386 19 1 4039. CST acknowledges Ramanujan fellowshi

    Microstructures and mechanical properties of ternary Ti�Si�Sn alloys

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    Titanium based alloys are one of the important structural materials with applications ranging from aerospace to biomedical industries. Several ternary Ti�Si�Sn alloys were explored in this study to design the microstructure comprising of binary and ternary eutectics corresponding to Ti�Si, Ti�Sn and Ti�Si�Sn system. The microstructural evolution in these alloys was studied using a combination of characterization techniques and thermodynamic calculations. The predicted solidification path from thermodynamic calculations well supported the experimental microstructural data. In addition, mechanical property and microstructure relationship were determined by performing hardness measurements and evaluating stress-strain curves under compression.by Chandra Sekhar Tiwary, Manas Paliwal, Sanjay Kashyap, Praful Pandey, Suman Sarkar, Ipshita Kundu, Shakti Bhaskar, In-Ho Jung, K.Chattopadhyay and Dipankar Banerje