Visualization 2. CCW pulses with period of 2 RTs.avi

“Invisible” pulsations of counterclockwise soliton molecules with period of 2 RTs

Visualization 1. CW pulses with period of 7 RTs.avi

“Invisible” pulsations of clockwise soliton molecules with period of 7 RTs

Visualization 3. CW pulses with period of 5 RTs.avi

“Invisible” pulsations of clockwise soliton molecules with period of 5 RTs

Visualization 4. CCW pulses with period of 5 RTs.avi

“Invisible” pulsations of counterclockwise soliton molecules with period of 5 RTs

Relationship between the correlation coefficient <i>r</i> and <i>x</i>/<i>y</i> for the estrogen derivatives in Table 1.

<p>For each <i>x</i>/<i>y</i> value, the total binding energy was calculated according to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074615#pone.0074615.e003" target="_blank">equation (3</a>) and the correlation coefficient <i>r</i> value is calculated by correlating the total binding energy for each chemical with its log<i>RBA</i>. The <i>x</i>/<i>y</i> value is shown in log scale.</p

Data_Sheet_1_Understanding creativity process through electroencephalography measurement on creativity-related cognitive factors.pdf

IntroductionNeurotechnology approaches, such as electroencephalography (EEG), can aid understanding of the cognitive processes behind creativity.MethodsTo identify and compare the EEG characteristics of creativity-related cognitive factors (remote association, common association, combination, recall, and retrieval), 30 participants were recruited to conduct an EEG induction study.ResultsFrom the event-related potential (ERP) results and spectral analysis, the study supports that creativity is related to the frontal lobe areas of the brain and common association is an unconscious process.DiscussionThe results help explain why some creativity-related cognitive factors are involved either more or less readily than others in the creative design process from workload aspects. This study identifies the part of the brain that is involved in the combination cognitive factor and detects the ERP results on cognitive factors. This study can be used by designers and researchers to further understand the cognitive processes of creativity.</p

Correlation of hydrogen bond length and log<i>RBA</i> of <i>A</i>-ring and <i>B</i>/<i>C</i>-ring derivatives.

<p>The hydrogen bond length data were shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074615#pone-0074615-t001" target="_blank"><b>Table 1</b></a>. The amino acids shown in the up right corner of each indicated that the hydrogen bonds were formed between 3-hydroxyl groups of the <i>A</i>-ring or <i>B</i>/<i>C</i>-ring derivatives and this specific amino acid in the binding pocket. The curve regression was performed according to the Inverse First Order equation y = y₀+ a/x.</p

The chemical structures of 17β-estradiol (E₂) and the 27 E₂ derivatives.

<p>The number of each carbon is labeled next to the atom in the E₂ structure. The names of the E₂ derivatives were shown in the upper left corner of each frame. The <i>RBA</i> values of the E₂ derivatives for ERα and ERβ (data from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074615#pone-0074615-t001" target="_blank"><b>Table 1</b></a> as % of <i>RBA</i> of E₂) were shown in the lower right corner of each frame. The numbers were rounded to the nearest integer due to space constraint.</p

The overlay of the ligand-binding domains (LBDs) of ERα and ERβ.

<p>The protein structures were shown in cartoon and colored green and magenta for ERα and ERβ, respectively. E₂ molecules were shown in stick and colored blue and red in ERα and ERβ LBD, respectively. α-Helixes and β-sheets in the ER LBDs are labeled according to references <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074615#pone.0074615-Brzozowski1" target="_blank">[14]</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074615#pone.0074615-Shiau1" target="_blank">[16]</a>. Helix 2 structures are missing in both <i>X</i>-ray structures.</p

Hydrogen bond lengths (Å) and calculated van der Waals interaction energy (Δ<i>E</i>_VDW, kcal/mol) and Coulomb interaction energy (Δ<i>E</i>_Coulomb, kcal/mol) between estrogen derivatives and the ERα and ERβ LBDs.

<p>Hydrogen bond lengths were quantified by measuring distances between the hydrogen atoms of the 3-hydroxyl group of estrogen derivatives and the O_ε of ERα-E353 or ERβ-E305, between the oxygen atoms of the 3-hydroxyl group of estrogen derivatives and the H_η of ERα-R394 or ERβ-R346 and between the hydrogen atoms of 17-hydroxyl group of estrogen derivatives and N_δ of ERα-H524 or ERβ-H475. For the <i>D</i>-ring derivatives, two hydrogen bond lengths were listed. The first is formed by hydrogen atoms of 17-hydroxyl groups and the second is formed by hydrogen atoms of 16-hydroxyl groups. Relative binding affinity (<i>RBA</i>) was also listed for comparison.</p