Supplementary Data from Effect of Bazedoxifene and Conjugated Estrogen (Duavee) on Breast Cancer Risk Biomarkers in High-Risk Women: A Pilot Study

Supplementary Tables 1-3</p

Supplementary Figure S3 from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

NEMO KD results in increased cell survival and proliferation in MCF7 cells in vitro.</p

Supplementary Figure S4 from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

NEMO KD results in decreased IL-6, p-serine STAT3 and PML in vivo.</p

Supplementary Figure S2. from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

NEMO is required for E+P induced expression of IL-6 and NFkB signaling in ER+PR+ overexpressing DCIS.com breast cancer cells.</p

Supplementary Table S1-S3 from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

S1:Differences in response to E+P were not correlated with any available patient data, including biomarker expression, age, or nuclear grade. S2:ER target genes with a role in NFkB pathway.S3:Relapse-free survival (RFS), distant metastasis-free survival (DMFS) and overall survival (OS) in all breast cancer patients or luminal A or B subtypes based on their expression levels of IKBKG and PML</p

Supplementary Figure S5 from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

Kaplan-Meier (KM) relapse-free and overall survival curves of breast cancer patients based on their expression levels of IKBKG, and PML.</p

Supplementary Figure S1. from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

Five ER+/PR+ DCIS patient samples were cultured under non adherent conditions and treated with E+P, E, P, and vehicle control. Only a subset of patient-derived ER+/PR+ DCIS cells responded to hormone treatment in vitro by increasing mammosphere formation efficiency.</p

Supplementary Material and Methods from NEMO, a Transcriptional Target of Estrogen and Progesterone, Is Linked to Tumor Suppressor PML in Breast Cancer

Description of additional experiments and procedures carried out in this study</p