Spectral properties of photon pairs generated by spontaneous four wave mixing in inhomogeneous photonic crystal fibers

The photonic crystal fiber (PCF) is one of the excellent media for generating photon pairs via spontaneous four wave mixing. Here we study how the inhomogeneity of PCFs affect the spectral properties of photon pairs from both the theoretical and experimental aspects. The theoretical model shows that the photon pairs born in different place of the inhomogeneous PCF are coherently superposed, and a modulation in the broadened spectrum of phase matching function will appear, which prevents the realization of spectral factorable photon pairs. In particular, the inhomogeneity induced modulation can be examined by measuring the spectrum of individual signal or idler field when the asymmetric group velocity matching is approximately fulfilled. Our experiments are performed by tailoring the spectrum of pulsed pump to satisfy the specified phase matching condition. The observed spectra of individual signal photons, which are produced from different segments of the 1.9 m inhomogeneous PCF, agree with the theoretical predictions. The investigations are not only useful for fiber based quantum state engineering, but also provide a dependable method to test the homogeneity of PCF.Comment: to appear in Phys. Rev.

A Self-attention Knowledge Domain Adaptation Network for Commercial Lithium-ion Batteries State-of-health Estimation under Shallow Cycles

Accurate state-of-health (SOH) estimation is critical to guarantee the safety, efficiency and reliability of battery-powered applications. Most SOH estimation methods focus on the 0-100\% full state-of-charge (SOC) range that has similar distributions. However, the batteries in real-world applications usually work in the partial SOC range under shallow-cycle conditions and follow different degradation profiles with no labeled data available, thus making SOH estimation challenging. To estimate shallow-cycle battery SOH, a novel unsupervised deep transfer learning method is proposed to bridge different domains using self-attention distillation module and multi-kernel maximum mean discrepancy technique. The proposed method automatically extracts domain-variant features from charge curves to transfer knowledge from the large-scale labeled full cycles to the unlabeled shallow cycles. The CALCE and SNL battery datasets are employed to verify the effectiveness of the proposed method to estimate the battery SOH for different SOC ranges, temperatures, and discharge rates. The proposed method achieves a root-mean-square error within 2\% and outperforms other transfer learning methods for different SOC ranges. When applied to batteries with different operating conditions and from different manufacturers, the proposed method still exhibits superior SOH estimation performance. The proposed method is the first attempt at accurately estimating battery SOH under shallow-cycle conditions without needing a full-cycle characteristic test

Research on deformation features and control strategies of repeated mining roadways in Guanjiaya Coal Mine

The surrounding rock of the repeated mining roadway is severely deformed and cannot be reused, and the repeated mining roadway has obvious overlapping extension features during the service period. In order to solve the above problems, this study takes the 13092 roadway of Guanjiaya Coal Mine as the research background, and adopts on-site measurement, numerical simulation, and theoretical analysis methods to investigate the overlapping extension features and control measures of repeated mining roadway deformation. The analysis of deformation features of repeated mining roadways shows the following points. ① Under a single mining disturbance, the deformation of repeated mining roadways exhibits zoning and asymmetric failure features, which can be divided into rapid deformation zone, strong deformation zone, and slow deformation zone. The crack damage mainly occurs in the coal wall and coal pillar walls, with less damage to the roof and floor, manifested as significant fragmentation and inward movement of the two sides of the roadway. Severe deformation occurs at the intersection of the coal wall and roof, as well as the coal pillar and floor. ② The secondary mining roadway expands and overlaps on the basis of the primary damage, making the asymmetric damage more significant and forming a butterfly shaped plastic failure zone in the surrounding rock of the roadway. ③ The key time for controlling the surrounding rock of the repeated mining roadway is the first mining stage. The key area is the coal pillar side of the roadway in the strong deformation zone and the slow deformation zone. By analyzing the butterfly deformation features and failure zoning rules of mining roadways, a multi-level coupling control technology for repeated mining roadways is proposed. Shallow low pressure - deep high pressure grouting is used to improve the support force of coal pillars. The anchor cables are used to reinforce and improve the support force of support bodies, achieving coupling control. The comparative analysis of deformation before and after reinforcement has verified that multi-level coupling control meets the requirements of roadway reuse

An experimental study of fault slips under unloading condition in coal mines

AbstractTo investigate the mechanism of fault slips in coal mines, a biaxial shear experiment was carried out under unloading condition based on the fault F16 in Yima city, China. Two rock samples were used in the experiment and each sample was composed of two triangular sandstone blocks which were put together to simulate the fault. One rock sample was used to do fault slip tests and it was called slip-test sample. The other sample for comparison with the slip-test one was untested, and it was named non-slip-test sample. During the biaxial shear experiment of the slip-test sample, normal and shear strains near the fault, acoustic emission (AE) signals, and the sliding displacement were measured. After the experiment, microscopic profiles of fault surfaces of both rock samples were examined by scanning electron microscope (SEM). In addition, a numerical simulation was conducted to model the slip of the fault F16. The results indicate that: (1) three fault slips occurred during the biaxial shear experiment, and the shear stress, normal and shear strains in the first slip showed the maximum variation among three slips; (2) Shear strains near the two ends of the fault had a more significate variation than that in the middle part, and the typical trend of shear strains was first dropping, then increasing rapidly, and then falling slowly to a specific value during the first slip; (3) The first slip had the largest sliding displacement of 29.89 μm, and in the first slip three phases including slow slip, main shock and aftershock occurred based on AE monitoring results. (4) On the fault surface of non-slip-test sample, microstructures such as bulges, voids and veins were ubiquitous and notable, making the fault surface much rough, while similar microstructures were few and the fault surface of the slip-test sample was flattened after fault slips; (5) The slipping direction in the shallow part and deep part of the fault F16 were opposite during mining.Abstract To investigate the mechanism of fault slips in coal mines, a biaxial shear experiment was carried out under unloading condition based on the fault F16 in Yima city, China. Two rock samples were used in the experiment and each sample was composed of two triangular sandstone blocks which were put together to simulate the fault. One rock sample was used to do fault slip tests and it was called slip-test sample. The other sample for comparison with the slip-test one was untested, and it was named non-slip-test sample. During the biaxial shear experiment of the slip-test sample, normal and shear strains near the fault, acoustic emission (AE) signals, and the sliding displacement were measured. After the experiment, microscopic profiles of fault surfaces of both rock samples were examined by scanning electron microscope (SEM). In addition, a numerical simulation was conducted to model the slip of the fault F16. The results indicate that: (1) three fault slips occurred during the biaxial shear experiment, and the shear stress, normal and shear strains in the first slip showed the maximum variation among three slips; (2) Shear strains near the two ends of the fault had a more significate variation than that in the middle part, and the typical trend of shear strains was first dropping, then increasing rapidly, and then falling slowly to a specific value during the first slip; (3) The first slip had the largest sliding displacement of 29.89 μm, and in the first slip three phases including slow slip, main shock and aftershock occurred based on AE monitoring results. (4) On the fault surface of non-slip-test sample, microstructures such as bulges, voids and veins were ubiquitous and notable, making the fault surface much rough, while similar microstructures were few and the fault surface of the slip-test sample was flattened after fault slips; (5) The slipping direction in the shallow part and deep part of the fault F16 were opposite during mining

Low dose radiotherapy combined with immune checkpoint inhibitors induces ferroptosis in lung cancer via the Nrf2/HO-1/GPX4 axis

BackgroundImmune checkpoint inhibitors (ICI) have revolutionized the therapeutic direction for lung cancer, yet their response rates remain unsatisfactory. Recently, the combination of ICI and low dose radiotherapy (LDR), a novel approach that effectively mobilizes innate and adaptive immunity, has gained interest among scientists. However, the underlying molecular mechanisms are not clearly elucidated.MethodsThe in vivo anti-tumor effects of LDR and ICI were measured in murine tumor models. The immune response and alterations in the tumor microenvironment were measured using flow cytometry and enzyme-linked immunosorbent assay (ELISA). Cell viability and death were assessed using CCK-8 assays. Fluorescent probes and ELISA were used to assess ferroptosis induced by the combination therapy in vitro and in vivo. Western blotting and qPCR were performed to detect alterations in the Nrf2/HO-1/GPX4 pathway. Furthermore, a phase 1 clinical trial with a combined regimen of LDR and anti-PD-1 antibodies in patients with lung cancer was conducted.ResultsThe combined LDR and ICI regimen exhibited considerable anti-tumor effects in murine tumor models, promoting immune response and increasing the IFN-γ levels. In vitro data showed that LDR plus ICI induced ferroptosis in cancer cells by increasing reactive oxygen species and MDA levels, promoting Fe2+ accumulation, and suppressing GSH. Furthermore, ferroptosis induced by combination therapy was associated with suppression of the Nrf2/HO-1/GPX4 antioxidant axis. Importantly, a phase 1 clinical trial of the combination therapy showed promising efficacy in patients with lung cancer with chemoimmunotherapy resistance.ConclusionThis study demonstrated that LDR plus ICI induces ferroptosis through the Nrf2/HO-1/GPX4 pathway, resulting in a significant anti-tumor effect and providing a combinatorial strategy to overcome lung cancer. However, this combined strategy merits further clinical investigation

Simulation of Pedestrian Crossing Behaviors at Unmarked Roadways Based on Social Force Model

Limited pedestrian microcosmic simulation models focus on the interactions between pedestrians and vehicles at unmarked roadways. Pedestrians tend to head to the destinations directly through the shortest path. So, pedestrians have inclined trajectories pointing destinations. Few simulation models have been established to describe the mechanisms underlying the inclined trajectories when pedestrians cross unmarked roadways. To overcome these shortcomings, achieve solutions for optimal design features before implementation, and help to make the design more rational, the paper establishes a modified social force model for interactions between pedestrians and vehicles at unmarked roadways. To achieve this goal, stop/go decision-making model based on gap acceptance theory and conflict avoidance models were developed to make social force model more appropriate in simulating pedestrian crossing behaviors at unmarked roadways. The extended model enables the understanding and judgment ability of pedestrians about the traffic environment and guides pedestrians to take the best behavior to avoid conflict and keep themselves safe. The comparison results of observed pedestrians’ trajectories and simulated pedestrians’ trajectories at one unmarked roadway indicate that the proposed model can be used to simulate pedestrian crossing behaviors at unmarked roadways effectively. The proposed model can be used to explore pedestrians’ trajectories variation at unmarked roadways and improve pedestrian safety facilities

The diagnostic value of metagenomics next-generation sequencing in HIV-infected patients with suspected pulmonary infections

BackgroundTraditional microbiological detection methods used to detect pulmonary infections in people living with HIV (PLHIV) are usually time-consuming and have low sensitivity, leading to delayed treatment. We aimed to evaluate the diagnostic value of metagenomics next-generation sequencing (mNGS) for microbial diagnosis of suspected pulmonary infections in PLHIV.MethodsWe retrospectively analyzed PLHIV who were hospitalized due to suspected pulmonary infections at the sixth people hospital of Zhengzhou from November 1, 2021 to June 30, 2022. Bronchoalveolar lavage fluid (BALF) samples of PLHIV were collected and subjected to routine microbiological examination and mNGS detection. The diagnostic performance of the two methods was compared to evaluate the diagnostic value of mNGS for unknown pathogens.ResultsThis study included a total of 36 PLHIV with suspected pulmonary infections, of which 31 were male. The reporting period of mNGS is significantly shorter than that of CMTs. The mNGS positive rate of BALF samples in PLHIV was 83.33%, which was significantly higher than that of smear and culture (44.4%, P<0.001). In addition, 11 patients showed consistent results between the two methods. Futhermore, mNGS showed excellent performance in identifying multi-infections in PLHIV, and 27 pathogens were detected in the BALF of 30 PLHIV by mNGS, among which 15 PLHIV were found to have multiple microbial infections (at least 3 pathogens). Pneumocystis jirovecii, human herpesvirus type 5, and human herpesvirus type 4 were the most common pathogen types.ConclusionsFor PLHIV with suspected pulmonary infections, mNGS is capable of rapidly and accurately identifying the pathogen causing the pulmonary infection, which contributes to implement timely and accurate anti-infective treatment

Accessible precisions for estimating two conjugate parameters using Gaussian probes

We analyze the precision limits for a simultaneous estimation of a pair of conjugate parameters in a displacement channel using Gaussian probes. Having a set of squeezed states as an initial resource, we compute the Holevo Cramér-Rao bound to investigate the best achievable estimation precisions if only passive linear operations are allowed to be performed on the resource prior to probing the channel. The analysis reveals the optimal measurement scheme and allows us to quantify the best precision for one parameter when the precision of the second conjugate parameter is fixed. To estimate the conjugate parameter pair with equal precision, our analysis shows that the optimal probe is obtained by combining two squeezed states with orthogonal squeezing quadratures on a 50:50 beam splitter. If different importance is attached to each parameter, then the optimal mixing ratio is no longer 50:50. Instead, it follows a simple function of the available squeezing and the relative importance between the two parameters

A Lactate Fermentation Mutant of Toxoplasma Stimulates Protective Immunity Against Acute and Chronic Toxoplasmosis

Toxoplasma gondii is an important zoonotic pathogen infecting one-third of the world’s population and numerous animals, causing significant healthcare burden and socioeconomic problems. Vaccination is an efficient way to reduce global sero-prevalence, however, ideal vaccines are not yet available. We recently discovered that the Toxoplasma mutant lacking both lactate dehydrogenases LDH1 and LDH2 (Δldh) grew well in vitro but was unable to propagate in mice, making it a good live vaccine candidate. Here, we tested the protection efficacy of ME49 Δldh using a mouse model. Vaccinated mice were efficiently protected from the lethal challenge of a variety of wild-type strains, including type 1 strain RH, type 2 strain ME49, type 3 strain VEG, and a field isolate of Chinese 1. The protection efficacies of a single vaccination were nearly 100% for most cases and it worked well against the challenges of both tachyzoites and tissue cysts. Re-challenging parasites were unable to propagate in vaccinated mice, nor did they make tissue cysts. High levels of Toxoplasma-specific IgG were produced 30 days after immunization and stayed high during the whole tests (at least 125 days). However, passive immunization of naïve mice with sera from vaccinated mice did reduce parasite propagation, but the overall protection against parasite infections was rather limited. On the other hand, Δldh immunization evoked elevated levels of Th1 cytokines like INF-γ and IL-12, at early time points. In addition, splenocytes extracted from immunized mice were able to induce quick and robust INF-γ and other pro-inflammatory cytokine production upon T. gondii antigen stimulation. Together these results suggest that cellular immune responses are the main contributors to the protective immunity elicited by Δldh vaccination, and humoral immunity also contributes partially. We also generated uracil auxotrophic mutants in ME49 and compared their immune protection efficiencies to the Δldh mutants. The results showed that these two types of mutants have similar properties as live vaccine candidates. Taken together, these results suggest that mutants lacking LDH were severely attenuated in virulence but were able to induce strong anti-toxoplasma immune responses, therefore are good candidates for live vaccines