Transition to lasing induced by resonant absorption

We theoretically demonstrate that increase of absorption with constant gain in laser systems can lead to onset of laser generation. This counter-intuitive absorption induced lasing (AIL) is explained by emergence of additional lasing modes created by an introduction of an absorbing medium with narrow linewidth. We show that this effect is universal and can be encountered in simple Fabry-Perot-like systems and doped spherical dielectric nanoresonators. The predicted behavior is robust against frequency detuning between the gain and absorbing medium

Nanostructured optical waveguide with a highly confined mode

We propose a transmission line working at telecom wavelengths with cross section as small as ${\lambda}^2/39$, which is 1.6 times smaller than that of optimized silicon waveguide. The proposed line can be implemented as a subwavelength fiber with plasmonic cladding. This considerable decrease in the line cross section is achieved by utilizing a plasmonic quasi-antisymmetric mode. The required plasmonic cladding is rather thin, therefore, losses are moderate and could be compensated by using amplifying core materials. Such a transmission line can find applications in densely integrated optical systems

Factor analysis of profit wholesale-retail pharmaceutical companies

The results of the analysis of the factors affecting the net profit and profitability of the pharmaceutical company. As an object of research performed one of the typical wholesale-retail pharmaceutical organizations. During the analysis found a negative effect on the value of absolute values of gross and net profit decrease in total turnover for 2009-2014 years. to 41.62%, revealed a compensatory effect on the value of the level of gross profit and net profit, changes in the structure of total turnover in the direction of increasing the proportion of groups with higher marginal income, and also demonstrated a negative effect on the growth of levels of financial performance costs

Channel spaser

We show that net amplification of surface plasmons is achieved in channel in a metal plate due to nonradiative excitation by quantum dots. This makes possible lossless plasmon transmission lines in the channel as well as the amplification and generation of coherent surface plasmons. As an example, a ring channel spaser is considered

Role of indole derivative SS-68 in increasing the frequency range of cardiac rhythm control (reflex stimulation of the sinoatrial node)

The substance SS-68 increases the frequency range of heart rhythm control by activating reflex stimulation of the sinoatrial node. The main point of application of SS-68 is the medulla oblongata. Glow in the high-frequency electromagnetic field reflects the process of neuron excitatio

Biomarkers in predicting mortality from cardiovascular events in patients with heart failure and an implanted cardioverter-defibrillator

Aim. To study the role of blood biomarkers in predicting death from cardiovascular events in patients with heart failure with reduced ejection fraction (HFrEF) within one year after cardioverter defibrillator (ICD) implantation.Material and methods. This one-center observation study included 384 HFrEF patients (men, 84%, NYHA class III – 74%, NYHA class IV – 7%), who underwent prospective observation for 1 year after ICD implantation. The study of the original panel of modern biomarkers (blood electrolytes, C-reactive protein, creatinine, soluble growth stimulation expressed gene 2 (sST2), N-terminal pro-brain natriuretic peptide (NT-proBNP), galectin-3), allowing to evaluate HF pathogenesis was conducted. Based on the blood creatinine concentration, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula was used to estimate the glomerular filtration rate (GFR).Results. In a one-year observation, the primary endpoint was recorded in 35 patients (11%). Single-factor logistic regression showed 3 biomarkers with the greatest predictive potential (p<0,01), related to the occurrence of the investigated endpoint. The concentration of potassium and NT-proBNP, the GFR (CKD-EPI) was included in the multi-factor predictive model with diagnostic efficiency of 68% (sensitivity of 60%, specificity 71%). It was shown that the cardiovascular death risk increased by 2,64 (OR=2,64; 95% CI: 1,28-5,46; p=0,007) at GFR <60 ml/min/1,73 m2 and increased by 3,32 (OR=3,32; 95% CI: 1,26-8,73; p=0,012) at NT-proBNP >2000 pg/ml.Conclusion. The study of blood biomarkers is promising and in demand for the prediction of adverse outcomes of HF. According to the data obtained, the factors «GFR <60 ml/min/1,73 m2» and «NT-proBNP >2000 pg/ml» may be relevant for one-year mortality prediction