Additional file 1 of HMMvar-func: a new method for predicting the functional outcome of genetic variants

Supplementary Tables. (XLSX 323 kb

female, 52 years, axial T2-weighted MRI shows lymphadenopathy (<i>arrow</i>), and portosystemic collaterals are shown as areas without signal intensity.

<p>female, 52 years, axial T2-weighted MRI shows lymphadenopathy (<i>arrow</i>), and portosystemic collaterals are shown as areas without signal intensity.</p

The situation of lymphadenopathy at different histological stages.

<p>Note: percentage = cases of patients / total number of patients with the corresponding histopathology.</p><p>The situation of lymphadenopathy at different histological stages.</p

male, 61 years, axial T2-weighted image shows periportal halo signs as hypointense areas around the portal veins (<i>arrows</i>).

<p>male, 61 years, axial T2-weighted image shows periportal halo signs as hypointense areas around the portal veins (<i>arrows</i>).</p

Specific distribution of enlarged lymph nodes.

<p>Specific distribution of enlarged lymph nodes.</p

Additional file 2 of HMMvar-func: a new method for predicting the functional outcome of genetic variants

Supplementary Figures. (PDF 102 kb

Clinical characteristics of the 45 PBC patients.

<p>Clinical characteristics of the 45 PBC patients.</p

female, 50 years, stage II with signal grade 2 and halo sign grade 2.

<p>female, 50 years, stage II with signal grade 2 and halo sign grade 2.</p

male, 61 years, diffuse hepatomegaly shown on coronal T2-weighted image.

<p>male, 61 years, diffuse hepatomegaly shown on coronal T2-weighted image.</p

female, 42 years, axial T2-weighted image shows splenomegaly and demonstrates periportal hyperintensity around medium-sized portal triads (<i>arrows</i>).

<p>female, 42 years, axial T2-weighted image shows splenomegaly and demonstrates periportal hyperintensity around medium-sized portal triads (<i>arrows</i>).</p