Zambia Signal Functions study 2016 dataset

This dataset contains information related to health facilities’ infrastructure, staffing, equipment, supplies, and capacity to perform various clinical functions related to reproductive and maternal health service provision. The study was conducted in Central Province, Zambia and its primary aim was to assess facilities’ capacity to provide termination of pregnancy services. EMBARGOED UNTIL 31st DEC 201

Additional file 8 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 8

Additional file 7 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 7

Additional file 5 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 5

Additional file 1 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 1

Additional file 6 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 6

Additional file 3 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 3

Additional file 4 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

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Additional file 2 of Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs

Additional file 2

Alternative Splicing of the Porcine Glycogen Synthase Kinase 3β (GSK-3β) Gene with Differential Expression Patterns and Regulatory Functions

<div><h3>Background</h3><p>Glycogen synthase kinase 3 (GSK3α and GSK3β) are serine/threonine kinases involved in numerous cellular processes and diverse diseases including mood disorders, Alzheimer’s disease, diabetes, and cancer. However, in pigs, the information on GSK3 is very limited. Identification and characterization of pig GSK3 are not only important for pig genetic improvement, but also contribute to the understanding and development of porcine models for human disease prevention and treatment.</p> <h3>Methodology</h3><p>Five different isoforms of GSK3β were identified in porcine different tissues, in which three isoforms are novel. These isoforms had differential expression patterns in the fetal and adult of the porcine different tissues. The mRNA expression level of GSK3β isoforms was differentially regulated during the course of the insulin treatment, suggesting that different GSK3β isoforms may have different roles in insulin signaling pathway. Moreover, GSK3β5 had a different role on regulating the glycogen synthase activity, phosphorylation and the expression of porcine GYS1 and GYS2 gene compared to other GSK3β isoforms.</p> <h3>Conclusions</h3><p>We are the first to report five different isoforms of GSK3β identified from the porcine different tissues. Splice variants of GSK3β exhibit differential activity towards glycogen synthase. These results provide new insight into roles of the GSK3β on regulating glycogen metabolism.</p> </div