2 research outputs found
Three-Component Cascade Annulation of β‑Ketothioamides Promoted by CF<sub>3</sub>CH<sub>2</sub>OH: A Regioselective Synthesis of Tetrasubstituted Thiophenes
A rapid and highly
efficient method for the regioselective synthesis
of thiophene derivatives has been developed by annulation of β-ketothioamides
with arylglyoxals and 5,5-dimethyl-1,3-cyclohexanedione in CF<sub>3</sub>CH<sub>2</sub>OH within 15 min. The present synthesis has
several desirable features, such as high regioselectivity, a concise
one-pot protocol, short reaction time, and easy purification. This
methodology provides an alternative approach for easy access to tetrasubstituted
thiophenes via a one-pot cascade reaction without other additives
Three-Component Cascade Annulation of β‑Ketothioamides Promoted by CF<sub>3</sub>CH<sub>2</sub>OH: A Regioselective Synthesis of Tetrasubstituted Thiophenes
A rapid and highly
efficient method for the regioselective synthesis
of thiophene derivatives has been developed by annulation of β-ketothioamides
with arylglyoxals and 5,5-dimethyl-1,3-cyclohexanedione in CF<sub>3</sub>CH<sub>2</sub>OH within 15 min. The present synthesis has
several desirable features, such as high regioselectivity, a concise
one-pot protocol, short reaction time, and easy purification. This
methodology provides an alternative approach for easy access to tetrasubstituted
thiophenes via a one-pot cascade reaction without other additives