Hubungan IL-10 Dengan Serum Kreatinin Dan Terjadinya Komplikasi Pada Preeklampsia Perawatan Konservatif

Tujuan: mengetahui hubungan penurunan IL-10 dengan terjadinya peningkatan serum kreatinin (SK) dan terjadinya komplikasi preeklampsia.Bahan dan Metode: penelitian ini merupakan analitik observasional yang dilakukan pada 30 wanita preeklampsia berat tipe dini yang dilakukan perawatan konservatif. Dilakukan pemeriksaan IL-10 pada serum darah dengan metode ELISA sebelum perawatan konservatif dan kemudian dinilai luaran maternal (SK dan komplikasi preeklampsia)Hasil: didapatkan rerata kadar IL-10 pada preeklampsia tipe dini 0,71 ± 0,66 pg/mL, rerata luaran SK 0,83 ± 0,29, terjadinya komplikasi 9 kasus (edema paru, impending eklampsia, sindroma HELLP). Tidak didapatkan hubungan antara IL-10 dengan peningkatan serum kreatinin (p = 0,483) dan komplikasi preeklampsia (p = 0,828).Simpulan: IL-10 bukan merupakan faktor prediktif untuk luaran maternal pada preeklampsia perawatan konservatif

Transplanting Cells from Old but Not Young Donors Causes Physical Dysfunction in Older Recipients

Adipose-derived mesenchymal stem cell (ADSC)-based regenerative therapies have shown potential for use in many chronic diseases. Aging diminishes stem cell regenerative potential, yet it is unknown whether stem cells from aged donors cause adverse effects in recipients. ADSCs can be obtained using minimally invasive approaches and possess low immunogenicity. Nevertheless, we found that transplanting ADSCs from old donors, but not those from young donors, induces physical dysfunction in older recipient mice. Using single cell transcriptomic analysis, we identified a naturally occurring senescent cell population in ADSCs primarily from old donors that resembles in vitro-generated senescent cells with regard to a number of key pathways. Our study reveals a previously unrecognized health concern due to ADSCs from old donors and lays the foundation for a new avenue of research to devise interventions to reduce harmful effects of ADSCs from old donors

First Enantioselective Syntheses of (+)- and (−)-Wilforonide by Using Chiral Auxiliaries Derived from the Same Chiral Source

The first enantioselective syntheses of both (+)-wilforonide (>98% ee) and (−)-wilforonide (>98% ee) have been accomplished by employing chiral auxiliaries derived from the same chiral source, (R)-pulegone. The bicyclic skeleton of wilforonide was constructed by using Mn(III)-based oxidative radical cyclization reactions of chiral β-keto esters. The absolute configuration of natural wilforonide has been established to be (5aR,9aR)

First Enantioselective Syntheses of (+)- and (−)-Wilforonide by Using Chiral Auxiliaries Derived from the Same Chiral Source

The first enantioselective syntheses of both (+)-wilforonide (>98% ee) and (−)-wilforonide (>98% ee) have been accomplished by employing chiral auxiliaries derived from the same chiral source, (R)-pulegone. The bicyclic skeleton of wilforonide was constructed by using Mn(III)-based oxidative radical cyclization reactions of chiral β-keto esters. The absolute configuration of natural wilforonide has been established to be (5aR,9aR)

Greenhouse Gas Implications of Fleet Electrification Based on Big Data-Informed Individual Travel Patterns

Environmental implications of fleet electrification highly depend on the adoption and utilization of electric vehicles at the individual level. Past research has been constrained by using aggregated data to assume all vehicles with the same travel pattern as the aggregated average. This neglects the inherent heterogeneity of individual travel behaviors and may lead to unrealistic estimation of environmental impacts of fleet electrification. Using “big data” mining techniques, this research examines real-time vehicle trajectory data for 10,375 taxis in Beijing in one week to characterize the travel patterns of individual taxis. We then evaluate the impact of adopting plug-in hybrid electric vehicles (PHEV) in the taxi fleet on life cycle greenhouse gas emissions based on the characterized individual travel patterns. The results indicate that 1) the largest gasoline displacement (1.1 million gallons per year) can be achieved by adopting PHEVs with modest electric range (approximately 80 miles) with current battery cost, limited public charging infrastructure, and no government subsidy; 2) reducing battery cost has the largest impact on increasing the electrification rate of vehicle mileage traveled (VMT), thus increasing gasoline displacement, followed by diversified charging opportunities; 3) government subsidies can be more effective to increase the VMT electrification rate and gasoline displacement if targeted to PHEVs with modest electric ranges (80 to 120 miles); and 4) while taxi fleet electrification can increase greenhouse gas emissions by up to 115 kiloton CO₂-eq per year with the current grid in Beijing, emission reduction of up to 36.5 kiloton CO₂-eq per year can be achieved if the fuel cycle emission factor of electricity can be reduced to 168.7 g/km. Although the results are based on a specific public fleet, this study demonstrates the benefit of using large-scale individual-based trajectory data (big data) to better understand environmental implications of fleet electrification and inform better decision making

Energy and Air Emissions Embodied in China−U.S. Trade: Eastbound Assessment Using Adjusted Bilateral Trade Data

It is critical to understand environmental impacts embodied in the bilateral trade between China and the United States, given the political, economic, and geographical importance of the two countries and the fact that few studies have investigated this before. This article studies the environmental impacts, particularly energy consumption and air emissions, embodied in the eastbound (from China to the U.S.) trade from 2002 to 2007 using an environmental input−output analysis technique and the adjusted bilateral trade data. In general, trade volume increased until the panic of 2008, and shifting trade patterns cause fluctuating embodied energy and air emissions in trade in China. Results show that embodied energy ranges from 7 to 11 exajoule (EJ) and takes about 12−17% of China’s energy consumption. Embodied CO2 ranges between 400 and 800 Mt and represents about 8−12% of China’s CO2 emissions. SO2 and NOx embodied in the eastbound trade generally grow over this period, from 4.2 to 6.3 Mt and from 1.4 to 2.9 Mt, and account for 10−15% and 8−12% of China’s total emissions, respectively

How Much Will China Weigh? Perspectives from Consumption Structure and Technology Development

Current patterns and future possibilities of China’s material metabolism are evaluated from perspectives of consumption structure change and technology development using the approach of input−output modeling to integrate ecological and economic systems. A physical input monetary output (PIMO) model is created and is applied to the Chinese economy with 43 sectors and 25 material categories. A set of scenarios, five exploring aspects of consumption structure change and three doing the same for technology development, is analyzed to quantitatively predict China’s future possible material metabolism patterns in 2010. The results provide a foundation for quantitative studies of resource consumption and waste generation in China, which given its increasing pivotal role in manufacturing is also helpful for research on the material metabolism of the entire world

Assessing Environmental Impacts Embodied in Manufacturing and Labor Input for the China−U.S. Trade

Previous studies on environmental impacts embodied in trade have paid little attention to the impacts of labor input, or environmental overhead of labor input (EOLI). EOLI occurs to support lifestyles both in the purchase of goods and services and in the consumption of fuels and electricity by workers. This research investigates both supply chain manufacturing and EOLI energy use and carbon dioxide (CO2) emissions embodied in the 2002 China−U.S. trade. EOLI is substantial in scale: 24% of manufacturing energy in the U.S. and 6% for China. The higher share of EOLI in the U.S. is the result of higher energy use to support worker lifestyles. Analysis shows China’s EOLI is dominated by the manufacturing of products consumed by workers, while EOLI on the U.S. side is primarily from workers’ direct consumption. The total manufacturing and EOLI energy and CO2 embodied in the eastbound trade from China to the U.S. are 6.5 exajoules (EJ) of energy (6% EOLI) and 440 million tons (Mt) of CO2 (8% EOLI). The total manufacturing and EOLI energy and CO2 embodied in the westbound trade from the U.S. to China are 424 petajoules (PJ) of energy (19% EOLI) and 25.3 Mt of CO2 (21% EOLI)

Enantioselective Construction of Carbobicyclic Scaffolds

Allylic and benzylic Grignard reagents smoothly open phenylalkynyl-activated cyclic trisubstituted epoxides at the more substituted carbon atom to give secondary alcohols with a chiral quaternary center. These alcohols are good substrates for the construction of enantiomerically pure carbobicyclic scaffolds through intramolecular alkylation