[(Ph)₃PBr][Br₇], [(Bz)(Ph)₃P]₂[Br₈], [(<i>n</i>-Bu)₃MeN]₂[Br₂₀], [C₄MPyr]₂[Br₂₀], and [(Ph)₃PCl]₂[Cl₂I₁₄]: Extending the Horizon of Polyhalides via Synthesis in Ionic Liquids

The five polyhalides [(Ph)3PBr][Br7], [(Bz)(Ph)3P]2[Br8], [(n-Bu)3MeN]2[Br20], [C4MPyr]2[Br20] ([C4MPyr] = N-butyl-N-methylpyrrolidinium), and [(Ph)3PCl]2[Cl2I14] were prepared by the reaction of dibromine and iodine monochloride in ionic liquids. The compounds [(Ph)3PBr][Br7] and [(Bz)(Ph)3P]2[Br8] contain discrete pyramidal [Br7]− and Z-shaped [Br8]2– polybromide anions. [(n-Bu)3MeN]2[Br20] and [C4MPyr]2[Br20] exhibit new infinite two- and three-dimensional polybromide networks and contain the highest percentage of dibromine ever observed in a compound. [(Ph)3PCl]2[Cl2I14] also consists of a three-dimensional network and is the first example of an infinite polyiodine chloride. All compounds were obtained from ionic liquids as the solvent that, on the one hand, guarantees for a high stability against strongly oxidizing Br2 and ICl and that, on the other hand, reduces the high volatility of the molecular halogens

[(Ph)₃PBr][Br₇], [(Bz)(Ph)₃P]₂[Br₈], [(<i>n</i>-Bu)₃MeN]₂[Br₂₀], [C₄MPyr]₂[Br₂₀], and [(Ph)₃PCl]₂[Cl₂I₁₄]: Extending the Horizon of Polyhalides via Synthesis in Ionic Liquids

The five polyhalides [(Ph)₃PBr][Br₇], [(Bz)(Ph)₃P]₂[Br₈], [(<i>n</i>-Bu)₃MeN]₂[Br₂₀], [C₄MPyr]₂[Br₂₀] ([C₄MPyr] = <i>N</i>-butyl-<i>N</i>-methylpyrrolidinium), and [(Ph)₃PCl]₂[Cl₂I₁₄] were prepared by the reaction of dibromine and iodine monochloride in ionic liquids. The compounds [(Ph)₃PBr][Br₇] and [(Bz)(Ph)₃P]₂[Br₈] contain discrete pyramidal [Br₇]⁻ and Z-shaped [Br₈]^2– polybromide anions. [(<i>n</i>-Bu)₃MeN]₂[Br₂₀] and [C₄MPyr]₂[Br₂₀] exhibit new infinite two- and three-dimensional polybromide networks and contain the highest percentage of dibromine ever observed in a compound. [(Ph)₃PCl]₂[Cl₂I₁₄] also consists of a three-dimensional network and is the first example of an infinite polyiodine chloride. All compounds were obtained from ionic liquids as the solvent that, on the one hand, guarantees for a high stability against strongly oxidizing Br₂ and ICl and that, on the other hand, reduces the high volatility of the molecular halogens

Sn₃I₈·2(18-crown-6): a Mixed-Valent Tin-Crown-Ether Complex

By reaction of SnI2, SnI4, and crown ether (18-crown-6) in the ionic liquid [NMe(n-Bu)3][N(Tf)2], Sn3I8·2(18-crown-6) is obtained in the form of black, plate-shaped crystals and crystallizes with a monoclinic lattice symmetry. In detail, Sn3I8·2(18-crown-6) is constituted of trigonal-bipyramidal [SnI5]−-anions and [Sn2I3(18-crown-6)2]+-cations. The cation exhibits an endocyclical coordination of Sn2+ by the crown ether. Both constituents are linked via long-ranging I−I contacts to form an infinite network. Besides crystal structure analysis, the mixed valence state of tin is evidenced by 119Sn-Mössbauer spectroscopy

sj-docx-1-soq-10.1177_14761270241242905 – Supplemental material for Institutional entrepreneurship and digital transformation: The role of outsider CEOs

Supplemental material, sj-docx-1-soq-10.1177_14761270241242905 for Institutional entrepreneurship and digital transformation: The role of outsider CEOs by Sebastian Firk, Jan C Hennig, Julian Meier and Michael Wolff in Strategic Organization</p

Additional file 2 of Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis

Additional file 2. Supplementary Dataset

Additional file 1 of Injections of concentrated bone marrow aspirate as treatment for Discogenic pain: a retrospective analysis

Additional file 1: Figure S1. (A) Proportion and 95% confidence intervals of patients with Numeric Rating Scale (NRS) score improvements of at least 30%. Proportions at each post-injection time point were 17.2, 54.2, 52.9, 41.2, and 44.4%, respectively. (B) Estimated NRS MCID of 2 points for patients reporting at least 30% improvement in pain scores. Proportions at each post-injection time point were 17.2, 45.8, 47.1, 35.3, and 38.9%, respectively. Visits are defined as follows: visit 1 (2 wks), visit 2 (6–8 wks), visit 3 (12 wks), visit 4 (6 mo), visit 5 (≥ 1 yr). The number of patients (N) with follow up data is listed below visit number. Figure S2. (A) Proportion and 95% confidence intervals of patients with Short Form-36 Health Survey (SF-36) score improvements of at least 30%. Proportions at each post-injection time point were 4.4, 35.7, 30.0, 44.4, and 30.8%, respectively. (B) Estimated SF-36 MCID of 18 points for patients reporting at least 30% improvement in pain scores. Proportions at each post-injection time point were 4.4, 35.7, 30.0, 44.4, and 38.5%, respectively. Visits are defined as follows: visit 1 (2 wks), visit 2 (6–8 wks), visit 3 (12 wks), visit 4 (6 mo), visit 5 (≥1 yr). The number of patients (N) with follow up data is listed below visit number. Figure S3. (A) Proportion and 95% confidence intervals of patients with Oswestry Low Back Pain Disability Index (ODI) score improvements of at least 30%. Proportions at each post-injection time point were 8.3, 46.7, 45.5, 66.7, and 38.5%, respectively. (B) Estimated ODI MCID of 12 points for patients reporting at least 30% improvement in pain scores. Proportions at each post-injection time point were 8.3, 26.7, 45.5, 77.8, and 30.8%, respectively. Visits are defined as follows: visit 1 (2 wks), visit 2 (6–8 wks), visit 3 (12 wks), visit 4 (6 mo), visit 5 (≥1 yr). The number of patients (N) with follow up data is listed below visit numbe

DataSheet1_On the road to sustainable transport: Acceptance and preferences for renewable fuel production infrastructure.PDF

To abate climate change and ameliorate the air quality in urban areas, innovative solutions are required to reduce CO2 and pollutant emissions from traffic. Alternative fuels made from biomass or CO2 and hydrogen can contribute to these goals by substituting fossil gasoline or diesel in combustion engines. Using a conjoint analysis approach, the current study investigates preferences of laypeople (n = 303) for fuel production facilities in terms of siting location, plant size, raw material used in the production, and raw material transport. The location was most decision-relevant, followed by raw material transport, whereas plant size and type of raw material played a less prominent role for the preference choice. The best-case scenario from the point of view of acceptance would be the installation of a rather small bio-hybrid fuel production plant in an industrial area (instead of an agricultural or pristine environment). No transport or transport via underground pipeline were preferred over truck/tank car or overground pipeline. The findings can be used as a basis for planning and decision-making for designing production networks for new fuel types.</p

DataSheet2_On the road to sustainable transport: Acceptance and preferences for renewable fuel production infrastructure.pdf

To abate climate change and ameliorate the air quality in urban areas, innovative solutions are required to reduce CO2 and pollutant emissions from traffic. Alternative fuels made from biomass or CO2 and hydrogen can contribute to these goals by substituting fossil gasoline or diesel in combustion engines. Using a conjoint analysis approach, the current study investigates preferences of laypeople (n = 303) for fuel production facilities in terms of siting location, plant size, raw material used in the production, and raw material transport. The location was most decision-relevant, followed by raw material transport, whereas plant size and type of raw material played a less prominent role for the preference choice. The best-case scenario from the point of view of acceptance would be the installation of a rather small bio-hybrid fuel production plant in an industrial area (instead of an agricultural or pristine environment). No transport or transport via underground pipeline were preferred over truck/tank car or overground pipeline. The findings can be used as a basis for planning and decision-making for designing production networks for new fuel types.</p

Discovery and translation of a target engagement marker for AMP-activated protein kinase (AMPK) - Fig 1

<p><b>A</b> AMPK Thr¹⁷²-phosphorylation in L6 myoblast after stimulation with 1μM compound 2 and western blot densitometry of 3 independent experiments <b>B</b> AMPK phosphorylation in human PBMCs after stimulation with 10μM compound 2. Bars represent the mean +/- SEM of three independent experiments of the fluorescent analysis with stimulated PBMCs from different donors. Signals on western blot are representative for 2 donors and illustrated in false colors.</p

Correlation of GPNMB increase (Fold-change expression vs. day 1, vehicle group) in whole blood of ZDF rats with increase in phospho-Thr¹⁷²-AMPK in two different tissues A Liver and B Quadriceps muscle.

Correlation of GPNMB increase (Fold-change expression vs. day 1, vehicle group) in whole blood of ZDF rats with increase in phospho-Thr172-AMPK in two different tissues A Liver and B Quadriceps muscle.</p