DataSheet_1_Effects of aerobic exercises in prediabetes patients: a systematic review and meta-analysis.docx

AimsTo evaluate the effects of different durations of continuous aerobic exercise on prediabetic patients.Materials and methodsThe research encompassed randomized controlled trials that examined how various durations of aerobic exercise training affected outcomes related to Body Mass Index (BMI), Fasting blood glucose (FBG), 2-hour plasma glucose (2hPG), and glycated hemoglobin (HbA1c) in individuals diagnosed with prediabetes. PubMed, Embase, Web of Science, and the Cochrane Library were searched as of January 7, 2023. The Cochrane Risk of Bias, version 2 (ROB 2) tool was used to assess the risk of bias.ResultsA total of 10 RCTs with 815 prediabetic patients were included. The average age of the participants was 56.1 years, with a standard deviation of 5.1 years. Among the participants, 39.2% were male. The interventions consisted of aerobic dance, treadmill running, walking, and a combination of aerobic exercises. The training sessions occurred three or four times per week. In prediabetic patients, aerobic exercise demonstrated a significant reduction in BMI compared to the control group, with a weighted mean difference (WMD) of -1.44 kg/m2 (95% confidence interval [CI] -1.89, -0.98). There was a decrease in FBG levels, with WMD of -0.51 mmol/L (95% CI -0.70, -0.32). Additionally, aerobic training led to significant improvements in 2hPG levels, with a WMD of -0.76 mmol/L (95% CI -1.14, -0.38). Furthermore, prediabetic patients showed a decrease in HbA1c levels after engaging in aerobic training compared to the control group, with a WMD of -0.34% (95% CI -0.45, -0.23).ConclusionIn summary, engaging in aerobic exercise can have a significant positive impact on glycemic levels in individuals with prediabetes. It can also lead to reductions in BMI, FBG, 2hPG, HbA1c, and other relevant indicators. The extent of these improvements may vary slightly depending on the duration of the aerobic exercise intervention.Systematic review registrationPROSPERO https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023395515.</p

Pneumocystis Pneumonia in Patients with Autoimmune Diseases: A Retrospective Study Focused on Clinical Characteristics and Prognostic Factors Related to Death

<div><p>Background</p><p>With the increasing use of immunosuppressive agents, the number of opportunistic infections has risen in patients with autoimmune diseases. Pneumocystis pneumonia (PCP) is one of these opportunistic infections that have a high mortality rate. However, only a few studies have described PCP in these patients, and these studies are limited in scope. We conducted this retrospective study to describe the clinical characteristics and factors associated with outcomes of PCP in patients with autoimmune diseases.</p><p>Methods</p><p>A retrospective study was performed in laboratory diagnosed PCP patients with autoimmune diseases in an academic hospital over a 10-year period. Patients with human immunodeficiency virus (HIV) infection were not included. Clinical characteristics were collected and the factors related to death were analysed.</p><p>Results</p><p>A total of 69 patients with PCP during the study period were included. Common clinical features included fever (81%), cough (56%), and dyspnea (35%). Ground glass opacity (81%) and reticulation (52%) were the most common radiological findings. Concurrent pulmonary infections including bacterium, aspergillus and cytomegalovirus were found in 34% of the patients. The overall in-hospital mortality rate was 32%. High mortality was associated with lower PaO₂/FiO₂ ratios and albumin levels. The lymphocyte count, CD4+ T cell count, previous usage of immunosuppressive agents, the duration and dose of glucocorticoids did not affect the outcome.</p><p>Conclusions</p><p>The mortality rate in PCP patients with autoimmune diseases is high. Low PaO₂/FiO₂ ratios and albumin levels are independent prognostic factors of mortality.</p></div

Multivariate analysis for Prognostic factors.

<p>Multivariate analysis for Prognostic factors.</p

Univariate analyses of risk factors among PCP patients determining survival rates.

<p>* Corticosteroids doses were expressed as the prednisolone equivalent dose</p><p>Univariate analyses of risk factors among PCP patients determining survival rates.</p

Demographical details, underlying diseases, and diagnostic procedures of the patients.

<p>* Vasculitis: Behcet’s disease, microscopic polyangiitis, granulomatosis with polyangiitis</p><p>** Other CTDs: Sjogren syndrome (SS), undifferentiated connective tissue disease (UCTD), mixed connective tissue disease, scleroderma</p><p># Immunosuppressive agents: cyclophosphamide, cyclosporin A, mycophenlatemofetil, and tripterygium glycosides</p><p>& Biological agents: ritaximab, and antitumor necrosis factor α(infliximab, entanercept)</p><p>Demographical details, underlying diseases, and diagnostic procedures of the patients.</p

Clinical manifestations, Radiologic characters and laboratory findings of the patients.

<p>* Included <i>pseudomonas aeruginosa</i> in three specimens, <i>Acinetobacter baumannii</i> in one specimen, <i>Klebsiella pneumonia</i> in one specimen</p><p>Clinical manifestations, Radiologic characters and laboratory findings of the patients.</p

Kaplan-Meier survival curve for the patients with pneumocystis pneumonia.

<p>Kaplan-Meier survival curve for the patients with pneumocystis pneumonia.</p

DataSheet_1_Nickel toxicity alters growth patterns and induces oxidative stress response in sweetpotato.xlsx

Nickel (Ni) contaminated soil is a persistent risk to plant growth and production worldwide. Therefore, to explore the Ni toxicity levels in sweetpotato production areas, we investigated the influence of different Ni treatments (0, 7.5, 15, 30, and 60 mg L-1) for 15 days on phenotype, Ni uptake, relative water content, gas exchange, photosynthetic pigments, oxidative stress, osmolytes, antioxidants, and enzymes of sweetpotato plants. The results presented that Ni at higher levels (30 and 60 mg L-1) substantially reduced growth, biomass, and root morphological traits. The Pearson correlation analysis suggested that Ni toxicity causes oxidative injuries as persistent augmentation of hydrogen peroxide (H2O2) and malonaldehyde (MDA) and reduced RWC, gas exchange, and photosynthetic pigment. Furthermore, this study revealed that sweetpotato could tolerate moderate Ni treatment (up to 15 mg L-1) by reducing oxidative stress. The results also indicated that the increase in the activities of mentioned osmolytes, antioxidants, and enzymes is not sufficient to overcome the higher Ni toxicity. Based on these results, we suggest using low Ni-contaminated soil for better growth of sweetpotato and also could be used as a phytoremediator in moderate Ni-contaminated soil.</p

Table_1_Nickel toxicity alters growth patterns and induces oxidative stress response in sweetpotato.xlsx

Nickel (Ni) contaminated soil is a persistent risk to plant growth and production worldwide. Therefore, to explore the Ni toxicity levels in sweetpotato production areas, we investigated the influence of different Ni treatments (0, 7.5, 15, 30, and 60 mg L-1) for 15 days on phenotype, Ni uptake, relative water content, gas exchange, photosynthetic pigments, oxidative stress, osmolytes, antioxidants, and enzymes of sweetpotato plants. The results presented that Ni at higher levels (30 and 60 mg L-1) substantially reduced growth, biomass, and root morphological traits. The Pearson correlation analysis suggested that Ni toxicity causes oxidative injuries as persistent augmentation of hydrogen peroxide (H2O2) and malonaldehyde (MDA) and reduced RWC, gas exchange, and photosynthetic pigment. Furthermore, this study revealed that sweetpotato could tolerate moderate Ni treatment (up to 15 mg L-1) by reducing oxidative stress. The results also indicated that the increase in the activities of mentioned osmolytes, antioxidants, and enzymes is not sufficient to overcome the higher Ni toxicity. Based on these results, we suggest using low Ni-contaminated soil for better growth of sweetpotato and also could be used as a phytoremediator in moderate Ni-contaminated soil.</p

The Presence of Lung Cancer Affects SARS-CoV-2 Vaccine Uptake and Attitude in Chinese Patients: A Clinical Cross-Sectional Investigation

With the SARS-CoV-2 mutations evolving and prompt of SARS-CoV-2 vaccines, no information is available on SARS-CoV-2 vaccination status in Chinese patients with lung cancer. An electronic questionnaire including sociodemographic characteristics, vaccine status, side effect post-vaccination, and attitude towards a fourth dose of vaccine was conducted within 1018 Chinese patients with lung cancer from October 18th, 2022, to November 25th, 2022. Among 1018 patients, a total of 75 (13.7%) patients reported acceptable systemic adverse events in those had received the SARS-CoV-2 vaccine (549, 54%), the most common of which was fever (39, 7%). Factors including females (OR, 1.512; 95% CI, 1.076–2.124), residents in the municipality (OR, 2.048; 95% CI, 1.238–3.389), undergoing therapy (OR, 2.897; 95% CI, 1.348–6.226), disagree to vaccines is safe for patients with lung cancer (OR, 3.816; 95% CI, 2.198–6.626) contributed to hesitancy. Among 373 patients had received three doses, half respondents (206, 55.2%) were hesitant to receive a fourth dose due to the safety concern and efficacy towards the variants. In conclusion, low vaccine uptake rates in patients with lung cancer could be improved by increasing confidence in vaccine safety, particularly for those with negative beliefs. Appropriate guidance and individualized vaccination plans that meet the healthcare needs of patients with lung cancer were needed during the constantly evolving pandemic.</p