Experimentelle Untersuchung uber die Augensymptome bei chronischer Bosmin-Vergiftung an Kaninchen, insbesondere uber die Herabsetzung der pupillo-motorischen Empfindlichkeit ( Bosmin-Starre )

Bosmin ist ein in Japan synthetisch hergestelltes Ersatzmittel von Adrenalin. Der Verfasser bezweckte an Kaninchen eine sehr chronische Bosmin-Vergiftung zu erzeugen und die dabei zu treffenden Augensymptome genau zu untersuchen. Zu diesem Zweck benutzte er eine taglich einmalige intravenose Injektion von sehr verdunnter Bosminlosung mit dem Bosmingehalt von 0.01 bis 0.05%, (von 0.02 mgr. Bosmin an wochentlich aufsteigend bis auf 0.2 mgr.), und hat auffallende Ergebnisse bekommen konnen. Durchschnittlich zeigte das Tier nach ungefahr 30 Injektionen deutliche Vergiftungszeichen am Auge, und solches Tier wurde von dem Verfasser Bosminvergiftetes Tier (B-V Tier) genannt. Die zu konstatierenden Augensymptome bei B-V Kaninchen sind folgende: 1. Massige Mydriasis. 2. Umkehr der Adrenalinwirkung auf die Pupille d. h. Verengerung der Pupille bei Adrenalin-Eintraufelung (Kontrolle: Mydriasis). 3. Kein Einfluss der Adrenalin-Eintraufelung auf den intraokularen Druck (Kontrolle: Drucksenkung). 4. Herabsetzung bis zur absoluten Starre der pupillo-motorischen Empfindlichkeit gegen das Licht (Differential-Pupilloskop nach Hess). Nun wurde diese vom Verfasser Bosmin-Starre genannte Empfindlich-keitherabsetzung der Pupille genauer und systematisch erforscht. Die Versuchsergebnisse sind folgende: 1. Die pupillo-motorische Empfindlichkeit gegen das Licht bei gesunden Kaninchen ist durchschnittlich ca. 0.900 (nach Hess) an beiden Augen (R: 0.893, L: 0.894). 2. Dieselbe bei B-V Kaninchen wurde an 20 Tieren, die 33 bis 190 Injektionen bekamen, genau gemessen und die bekommenen Z?hlen sind folgende: Empfindlichkeit (E) 0 an 9 Augen, E unter 0.50 an 11 Augen, E unter 0.70 an 9 Augen, E unter 0.80 an 5 Augen und E uber 0.80 an 6 Augen. Es wurden weiter merkwurdige Ergebnisse an dem Verhalten der Bosmin-Starre , insbesondere an ihrem innigen Zusammenhang mit dem obersten Halsganglion konstatiert: 1. Unterbrechung der Injektion verursacht eine allmahliche Wiederherstellung der pupillo-motorischen Empfindlichkeit, welche in ca. 30 Ta

Monolithic Perovskite Solar Capacitor Enabled by Double-Sided TiO₂ Nanotube Arrays

An integrated power pack that renders simultaneous solar energy harvesting and storage represents a particularly promising energy source toward future applications. Herein, we report a high-performance hybrid power pack of perovskite solar cell (PSC) and supercapacitor via capitalizing on double-sided TiO2 nanotube arrays that have a dual-function as electron transport layer (ETL) for PSC and cathode for supercapacitor, respectively (i.e., a monolithic perovskite solar capacitor). Specifically, a simple yet robust acid-treatment strategy followed by selective oxygen plasma exposure on only the PSC side is employed to concurrently increase the performance of double-sided TiO2 nanotube electrodes in both the PSC and supercapacitor units. Intriguingly, the integrated power pack delivers fast response under photocharging because of efficient charge transfer across the two sides of the TiO2 nanotube array electrode, attaining a high overall optoelectrical energy conversion and storage efficiency of 9.18%. This work demonstrates a viable route to engineering intimately linked energy conversion–storage systems of interest

Floridan Aquifer Collaborative Engagement for Sustainability (FACETS) - Field trial data from Live Oak, Florida: ARDN products

ARDN (Agricultural Research Data Network) annotations for "Floridan Aquifer Collaborative Engagement for Sustainability (FACETS) - Field trial data from Live Oak, Florida". The ARDN project (https://usda.figshare.com/ARDN) is a network of datasets harmonized and aggregated using a common vocabulary termed ICASA. ICASA is a recommended data dictionary by USDA NAL (https://data.nal.usda.gov/data-dictionary-examples) described in detail here: www.tinyurl.com/icasa-mvl. ARDN provides dataset annotations which facilitate interoperability. For information on how to use ARDN annotations and other data products, see https://agmip.github.io/ARDN/ARDN_how.html. Research was conducted at the North Florida Research and Education Center - Suwannee Valley, located near Live Oak, Florida (30°18’22” N, 82°54’00” W). Corn, carrots, peanuts, and rye (cover crop) were grown on Hurricane, Chipley, and Blanton soil complexes that are all over 90% sand. They contain very little organic material or clays and have very low water holding capacity. The experimental design utilized a randomized complete block design with split plot that incorporated two fields with eight blocks (treatment replicates) and fifteen plots per block. The main plots contained four irrigation treatments, and the sub-plots contained three different nitrogen rates. The SMS irrigation treatment contained three additional nitrogen treatments. The plots were 12 m x 6 m separated by 6 m alleys. Each block was separated by a 12 m alley. The north field in the study (System 2) was a corn-cover crop-peanut-cover crop rotation, while the south field (System 1) was a corn-carrot-peanut-cover crop rotation. During each growing season, soil moisture was monitored using capacitance type soil moisture sensors, soil nitrogen was measured through bi-weekly soil samples at four depths, and biomass was collected four times with the final sample being collected just prior to harvest. Biomass included dry weight of separate plant tissues as well as Total Kjeldahl Nitrogen (TKN) and yield. Resources in this dataset:Resource Title: ARDN SC2 for FACETS Field trial data from Live Oak, Florida. File Name: FACETS-SC2.jsonResource Description: ARDN sidecar 2 file which allows dataset to be automatically interpreted and translated to end user formats.Resource Software Recommended: AgMIP / ARDN Data Factory,url: https://data.agmip.org/ardn/tools/data_factory </ul

Floridan Aquifer Collaborative Engagement for Sustainability (FACETS) - Field trial data from University of Georgia Stripling Irrigation Research Park (SIRP): ARDN Products

ARDN (Agricultural Research Data Network) annotations for "Floridan Aquifer Collaborative Engagement for Sustainability (FACETS) - Field trial data from University of Georgia Stripling Irrigation Research Park (SIRP)". The ARDN project (https://usda.figshare.com/ARDN) is a network of datasets harmonized and aggregated using the ICASA vocabulary, as recommended by USDA NAL (https://data.nal.usda.gov/data-dictionary-examples) and described in detail here: www.tinyurl.com/icasa-mvl”. ARDN provides dataset annotations which facilitate interoperability. For information on how to use ARDN annotations and other data products, see https://agmip.github.io/ARDN/ARDN_how.html. Research was conducted at the University of Georgia’s Stripling Irrigation Research Park (SIRP) located near Camilla, Georgia in a 4 ha research field known as the Newton Lateral (31°16'46.24"N, 84°17'59.59"W). The field is divided into three blocks (North, Middle, South) with each block containing 27 plots. The plots were each 14.5 × 14. 5 m (48 × 48 ft or 48 ft long × 16 rows wide). The eight middle rows in each plot were used for data collection and the four rows on either side of the middle eight served as buffers. The soil in the Newton Lateral field is classified as a Lucy Loamy Sand with available water holding capacity of 0. 08 cm/cm with 0 to 5% slope. Soil texture varies slightly across the field with 83% Sand, 10% Silt and 7% Clay in the South block to 86% Sand, 8% Silt, and 6% Clay in the North block. The field is irrigated with a variable rate enabled lateral irrigation system which can apply a unique water application rate to each of the 81 plots. A portable liquid fertilizer injection system allows for application of unique fertilizer application rate to each of the 81 plots through the irrigation system (fertigation). The experimental design utilized a randomized complete block design. The 27 plots in each block were divided into nine treatments with three replicates each. A cotton-peanut-corn rotation was maintained with crops rotating from north to south each year. All crops were planted into a rye cover crop using strip tillage following burndown with glyphosate. Three irrigation × three fertilization treatments were evaluated in the corn and cotton plots. Since N fertilizer is not applied to peanut during the growing season, nine irrigation treatments were evaluated in peanut. During each growing season, soil moisture was monitored continuously in each plot using matric potential type soil moisture sensors in all crops. Soil nitrogen and rye cover crop biomass was measured prior to burndown. Soil nitrogen and crop biomass was measured at regular intervals during the growing season with the final sample being collected just prior to harvest. Biomass included dry weight of separate plant tissues as well as Total Kjeldahl Nitrogen (TKN) and yield. Soil samples were collected to 0.9 m in 4 increments and analyzed for Nitrate, Ammonium, and TKN. For more information about this dataset contact: Cheryl H. Porter: [email protected] Meng Zhang: [email protected] Resources in this dataset:Resource Title: SC2 files for "FACETS BMP Field Trial Data from Stripling Irrigation Research Park, Georgia" dataset. File Name: SC2_FACETS BMP Field Trial Data from Stripling Irrigation Research Park, Georgia.zipResource Description: File contains 11 SC2 files for the "FACETS BMP Field Trial Data from Stripling Irrigation Research Park, Georgia" dataset, one file for each file in the original dataset. Resource Software Recommended: AgMIP Data Factory,url: https://data.agmip.org/ardn/tools/data_factory </ul

Selective Determination of HOCl in Environmental Water Samples and Real-Time Detection of HOCl Levels in Live Cells via Ratio Fluorescence Imaging Based on Eu³⁺-Modified and Carbon Dot-Encapsulated Metal Organic Frameworks

Hypochlorous acid (HOCl) is one kind of significant ROS and a typical environmental pollution, which is closely linked to our food chain and threatens human health. Hence, a dual-emission ratiometric fluorescent nanoprobe (N-CDs@Eu-UiO-66-(COOH)2) for sensitive and specific determination of HOCl was fabricated based on Eu3+-modified and carbon dot-encapsulated MOFs. The N-CDs were encapsulated into MOFs, which can greatly improve their photostability and resistance to photobleaching in aqueous solution. The N-CDs@UiO-66-(COOH)2 was modified by Eu3+ ions, which can emit the red characteristic fluorescence of Eu3+ ions via the antenna effect. HOCl can quench the fluorescence of N-CDs through oxidizing hydroxyl groups on its surface, while the characteristic fluorescence of Eu3+ remains unchanged. The ratiometric fluorescence nanoprobe of N-CDs@Eu-UiO-66-(COOH)2 was thus fabricated for detecting HOCl. The nanoprobe has high sensitivity and selectivity, and its LOD (3σ/K) can attain 15.0 nM. Moreover, the N-CDs@Eu-UiO-66-(COOH)2 nanoprobe can also be applied for real-time detection of HOCl levels in the live cells via ratio fluorescence imaging, which can serve as a noninvasive tool for sensitively detecting fluctuations of HOCl levels in the living cells. This work can provide a promising application in environmental monitoring and real-time monitoring HOCl levels in vivo

Study on vibration isolation performance of composite multilayer wave impeding block based on wave impedance ratio under an underground dynamic load

Abstract Based on the theory of single-phase elastic medium and unsaturated porous medium, the vibration isolation effect of composite multilayer wave impeding block (WIB) in the unsaturated ground under an underground dynamic load is investigated. The results show that the best vibration isolation effect can be obtained by designing the wave impedance ratio between the composite multilayer WIB and unsaturated ground. The composite multilayer WIB improves the vibration-damping bandwidth compared with the homogeneous WIB. The vibration isolation effect is better the closer the embedded depth of the composite multilayer WIB is to the vibration source, and its vibration isolation effect increases significantly with the increase of thickness, but when the thickness of the WIB exceeds a certain critical thickness, its vibration isolation effect decreases with the increase of thickness. Soil saturation has a significant effect on the vibration isolation effect of composite multilayer WIB in the unsaturated ground, and the composite multilayer WIB can achieve a better vibration isolation effect at low saturation.</div

Table_1_Compare the physicochemical and biological properties of engineered polymer-functionalized silver nanoparticles against Porphyromonas gingivalis.DOCX

BackgroundSome polymer-functionalized AgNPs (P-AgNPs) have been developed to optimize the biological properties of AgNPs. However, there are no studies in the literature comparing the differences in physicochemical and biological properties of AgNPs caused by various polymer-functionalizations and providing evidence for the selection of polymers to optimize AgNPs.MethodsTwo AgNPs with similar nano-size and opposite surface charges were synthesized and functionalized by seven polymers. Their physicochemical properties were evaluated by UV-Visible absorption, dynamic light scattering, transmission electron microscopy and inductively coupled plasma optical emission spectroscopy. Their biological properties against Porphyromonas gingivalis and human gingival fibroblast were investigated by MIC determination, time-dependent antibacterial assay, antibiofilm activity and cell viability assay. Silver diamine fluoride, AgNO3 and metronidazole were used as positive controls.ResultsComparative analysis found that there were no significant differences between P-AgNPs and AgNPs in nano-size and in surface charge. Raman spectroscopy analysis provided evidence about the attachment of polymers on AgNPs. For antibacterial property, among the negatively charged AgNPs, only polyvinylpyrrolidone (PVP)-functionalized AgNPs-1 showed a significant lower MIC value than AgNPs-1 (0.79 vs. 4.72 μg/ml). Among the positively charged AgNPs, the MIC values of all P-AgNPs (0.34–4.37 μg/ml) were lower than that of AgNPs-2 (13.89 μg/ml), especially PVP- and Pluronic127-AgNPs-2 (1.75 and 0.34 μg/ml). For antibiofilm property, PVP-AgNPs-1 (7.86 μg/ml, P = 0.002) and all P-AgNPs-2 (3.42–31.14 μg/ml, P ConclusionAmong the polymers studied, polymer functionalization does not significantly alter the physical properties of AgNPs, but modifies their surface chemical property. These modifications, especially the functionalization of PVP, contribute to optimize the antibacterial and antibiofilm properties of AgNPs, while not causing cytotoxicity at the MIC level.</p

Supplementary document for Origin of frequency-sensitive super-collimation phenomenon from the geometry of band dispersion surface for two-dimensional photonic crystals - 5732096.pdf

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Table_1_The more ambidexterity the better? The moderating effect of organizational learning between high-performance HR practices and organizational performance.pdf

ObjectiveThe objective of this study is to test the directly impact of high-performance HR practices on organizational performance, and the mediating effect of organizational ambidexterity empirically. Moreover, the moderating role of organizational learning in the relationship between ambidexterity and specialization in exploitation or exploration on firm performance has also been examined. Ultimately, we construct a moderated mediation model.MethodsQuestionnaires were distributed to the target enterprises mainly through the contacts of the research group members, the local management consulting association and the training opportunities for leaders. Finally, a total of 347 CEO questionnaire data were collected from Chinese SMEs. The sample cover Shanghai, Beijing, Chongqing, Jiangsu, Zhejiang, Guangdong, Henan, Sichuan and other eastern and central regions. SPSS 23.0 and AMOS 24.0 were used to analyze the data.ResultsThe results revealed that high-performance HR practices had a positive effect on organizational performance and that organizational ambidexterity played a partially mediating role between high-performance HR practices and organizational performance. Further, organizational learning moderated the effects of organizational ambidexterity and organizational specificity on firm performance.DiscussionThis study provided valuable practical insights. On one hand, this study provides a concrete operational scheme for SMEs in China to realize organizational ambidexterity by integrating a series of HR practices such as employees’ ability, motivation and opportunity. On the other hand, through organizational ambidexterity, firms can not only obtain organizational long-term performance by enhancing their new product R & D capabilities, that is, exploratory innovation, but also utilize their existing resources to improve and expand their existing products and services, that is, to achieve short-term performance by exploitative innovation.</p

Table_3_Predictors of Persistent Participation in Youth Sport: A Systematic Review and Meta-Analysis.docx

There are many factors affecting decisions to persistent participation in sports and various approaches have been used to frame these antecedents. The aim of this paper was to systematically review and quantify the primary factors of persistent participation and to assess their respective strengths of association with persistent participation in youth sport. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA) guidelines, a comprehensive search was implemented on 31st December 2021 in five databases and meta-analytic procedures were applied to data from studies meeting inclusion criteria. The results revealed that sports enjoyment (meta r = 0.45, 95%CI [0.42, 0.49]) was highly correlated with persistent intention, while persistent intention (SMD = 1.13, 95%CI [0.70, 1.56]) was highly correlated with persistent behavior. In addition, parental support, coach support, peer support, basic psychological needs and sports competence were the primary factors associated with persistent intention and persistent behavior, respectively. This study identified the key factors related to persistent participation and provide a complete understanding of children and adolescents' decisions to continue their participation in organized sports. Referring to the key factors, it can provide information for sports clubs and policy makers to develop strategies to increase youth participation in organized sport.Systematic Review RegistrationPROSPERO, identifier: CRD42021229397.</p