Number of significant profiles found when comparing signature profiles of treatment and control samples.

The cell lines are categorized according to the number of DEGs and the DEG have been estimated based on the z-score signatures profiles.</p

Distributions of unique dosages for the signature profiles.

The number of available profiles is shown for different dosages (concentrations) of small molecules for 9 highly profiled cell lines.</p

Distribution of experimental conditions for 9 highly profiled cell lines.

Each stack bar shows the proportion of available profiles for different small molecules and controls used for the experimental condition.</p

List of LINCS L1000 metadata APIs.

List of LINCS L1000 metadata APIs.</p

Summary of z-score signature profiles resulting in differentially expressed genes (DEG) between treatment and control samples for the 9 cell lines in Table 2.

Summary of z-score signature profiles resulting in differentially expressed genes (DEG) between treatment and control samples for the 9 cell lines in Table 2.</p

Drug perturbation specific differentially gene expression.

The differential expression of genes for 9 cell lines is shown categorized in the time durations (6 and 24h) of drug perturbations.</p

Cell lines with the highest number of available signature profiles in the LINCS L1000 data and their corresponding annotation according to the Cell Service API.

Cell lines with the highest number of available signature profiles in the LINCS L1000 data and their corresponding annotation according to the Cell Service API.</p

Cell line signature profile counts.

The drug signature profile count distribution is shown for all 71 cell lines across all experiments in the LINCS L1000 dataset. Each bar gives the number of available signature profiles per cell line.</p

Changes of biological activity.

Percentage changes in the number of significant profiles for the cell lines in dependence on the dosages and time points obtained from Figs 6 and 7. A. corresponds either to Low dosage or 6 hours and B. corresponds either to High dosage and 24 hours.</p

Distributions of experimental replicates for the signature profiles.

The number of available replicates is shown for small molecule treatments in the LINCS L1000 data for 9 highly profiled cell lines.</p