Austerity, Inequality, and Private Debt Overhang

We show that the distributional consequences of fiscal consolidations depend significantly on the level of private indebtedness. Austerity leads to a strong and persistent increase in income inequality when private debt is high. In contrast, there are no discernible distributional effects when private debt is low. This result is robust to alternative identifications of consolidations, to different ways of defining high and low debt states, and to controlling for the state of the business cycle

Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma

The prevalence of global obesity is increasing. Obesity is associated with general cancer-related morbidity and mortality and is a known risk factor for development of specific cancers. A recent large systematic review of 24 studies based on meta-analysis of 11,149 patients with prostate cancer showed a significant correlation between obesity and the risk of advanced prostate cancer. Further, a sustained reduction in BMI correlates with a decreased risk of developing aggressive disease. On the other hand, the correlation between consuming different products and prostate cancer occurrence/risk is limited. Here, we review the role of adipose tissue from an endocrine perspective and outline the effect of adipokines on cancer metabolism, with particular focus on leptin. Leptin exerts its physiological and pathological effects through modification of intracellular signalling, most notably activating the Janus kinase (JAK) 2/signal transducer and activator of transcription (STAT) 3 pathway and recently shown sphingolipid pathway. Both high levels of leptin in circulation and leptin receptor mutation are associated with prostate cancer risk in human patients; however, the in vivo mechanistic evidence is less conclusive. Given the complexity of metabolic cancer pathways, it is possible that leptin may have varying effects on prostate cancer at different stages of its development, a point that may be addressed by further epidemiological studies

Austerity, inequality and private debt overhang

Using panel data of 17 OECD countries for 1980-2011, we find that the distributional consequences of fiscal consolidations depend significantly on the level of private indebtedness. Austerity leads to a strong and persistent increase in income inequality during periods of private debt overhang. In contrast, there are no discernible distributional effects when private debt is low. This result is robust to alternative identifications of fiscal consolidations, to different ways of defining periods of private debt overhang, and to controlling for the state of the business cycle. We explore different channels through which our findings can be rationalized

The basic ideas and prospects

The locomotive theory is likely to come up again for discussion at the next summit of the major industrial nations in Bonn in July. What are the basic ideas behind this theory? And what are its chances of success if adopted as an economic policy

Dynamic spin-Hall effect and driven spin helix for linear spin-orbit interactions

We derive boundary conditions for the electrically induced spin accumulation in a finite, disordered 2D semiconductor channel. While for DC electric fields these boundary conditions select spatially constant spin profiles equivalent to a vanishing spin-Hall effect, we show that an in-plane ac electric field results in a non-zero ac spin-Hall effect, i.e., it generates a spatially non-uniform out-of-plane polarization even for linear intrinsic spin-orbit interactions. Analyzing different geometries in [001] and [110]-grown quantum wells, we find that although this out-of-plane polarization is typically confined to within a few spin-orbit lengths from the channel edges, it is also possible to generate spatially oscillating spin profiles which extend over the whole channel. The latter is due to the excitation of a driven spin-helix mode in the transverse direction of the channel. We show that while finite frequencies suppress this mode, it can be amplified by a magnetic field tuned to resonance with the frequency of the electric field. In this case, finite size effects at equal strengths of Rashba- and Dresselhaus SOI lead to an enhancement of the magnitude of this helix mode. We comment on the relation between spin currents and boundary conditions.Comment: 10 pages, 5 figures, added references, corrected typos, extended section V, VI

EasyStrata: evaluation and visualization of stratified genome-wide association meta-analysis data

Summary: The R package EasyStrata facilitates the evaluation and visualization of stratified genome-wide association meta-analyses (GWAMAs) results. It provides (i) statistical methods to test and account for between-strata difference as a means to tackle gene-strata interaction effects and (ii) extended graphical features tailored for stratified GWAMA results. The software provides further features also suitable for general GWAMAs including functions to annotate, exclude or highlight specific loci in plots or to extract independent subsets of loci from genome-wide datasets. It is freely available and includes a user-friendly scripting interface that simplifies data handling and allows for combining statistical and graphical functions in a flexible fashion. Availability: EasyStrata is available for free (under the GNU General Public License v3) from our Web site www.genepi-regensburg.de/easystrata and from the CRAN R package repository cran.r-project.org/web/packages/EasyStrata/. Contact: [email protected] or [email protected] Supplementary information: Supplementary data are available at Bioinformatics onlin