5 research outputs found

    Extracellular levels of granzyme A and B on admission and during discharge in patients.

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    <p>Typhoid fever patients (n = 15) who were discharged from hospital had lower levels of granzymes at follow-up when patients were clinically improved (granzyme A; A), although this did only reach statistical significance for granzyme B (B). Medians are shown. Significance determined via Mann-Whitney <i>U</i> tests. *P<0.05. Gzm: granzyme.</p

    Extracellular levels of granzyme A and B in patients with typhoid fever and healthy controls, and correlation with IFN- γ levels.

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    <p>Plasma levels of granzyme A (A) and B (B) measured in healthy controls (n = 38) compared to admission samples of hospitalized typhoid fever patients (n = 28). Medians are shown. Significance determined via Mann-Whitney <i>U</i> tests. ***P<0.001. Granzyme A is correlated to granzyme B (C). Levels of granzyme A (D) and granzyme B (E) are correlated to interferon (IFN)-γ in patients. Correlation coefficient reported is for Spearman's Rho. Gzm: granzyme.</p

    Expression of granzymes A, B and K by each lymphocyte subtype in patients with typhoid fever and controls.

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    <p>Percentage of lymphocyte population expressing each granzyme (A–D) and MFI of the intracellular expression of each granzyme in the lymphocyte populations (E–H). n = 36 controls and 8 patients. MFI values are expressed with Log10 scale. Significance determined via Mann-Whitney <i>U</i> tests. Medians are shown. Analysis was done by flow cytometry. MFI: median fluorescence intensity; NK cells: CD3<sup>−</sup>CD56<sup>+</sup>. *P<0.05, **P<0.01, ***P<0.001.</p
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