Digital Literacy among Medical Sciences Students: A Systematic Review and Meta-Analysis

Background: The rapid advancement of digital technology and information has revolutionized teaching approaches, research practices, and evidence retrieval in medical academic settings, highlighting the necessity for adequate digital literacy (DL) among students. This research delved into examining digital literacy and its various components within the medical sciences student population.Method: Surveys about medical sciences students’ DL and related topics were identified by searching of the Web of Science, Scopus, Embase, and PubMed databases. Meta-analysis was done using CMA V.3.3.Results: Out of the 6773 initially identified articles, 54 studies were selected for the final synthesis. The studies showed that the DL of medical science students has improved over the past two decades. However, there were differences in the components of DL, with computer literacy ranking the highest and search literacy ranking the lowest. Result of meta-analysis of 28 studies for estimation of the rate of skilled students in performing tasks using digital devices showed that most students were skilled in using Word Processing (78%) and Presentation (68%) software, while fewer were skilled in using Spreadsheets (49%) and Email (34%).Conclusion: While in recent years, medical science students have made significant progress in DL, a gap remains between their expected competency and the current situation. The COVID-19 pandemic accelerated the adoption of digital technologies for online learning, positively impacting students’ DL. This valuable experience should guide future educational practices, emphasizing continued online and blended learning, and focusing on integrating ICT courses into the medical science curriculum

Association between Genetic Variants Linked to Premature Ovarian Insufficiency and Inflammatory Markers: A Cross-Sectional Study

Background: Premature menopause (PM) is the cessation of ovarian function before age 40. PM women are more likelyto have cardiovascular diseases (CVDs), diabetes, and mental disorders. This is the first study that assessed the associationof single nucleotide polymorphisms (SNPs) with anti-heat shock protein 27 (Hsp27), High-sensitivity C-reactive protein(hs-CRP), and PM and serum pro-oxidant-antioxidant balance (PAB), as putative risk factors for CVDs. We aimed toexplore the association of oxidative stress markers with eight different SNPs shown to be related to premature menopause.Materials and Methods: In this cross-sectional research, we included 183 healthy women and 117 premature menopausalwomen. We determined baseline characteristics for all participants and measured serum hs-CRP, anti-HSP-27 antibody titer, and PAB levels using the established methods. Genotyping for eight SNPs was done usingthe tetra amplification refractory mutation system polymerase chain reaction (Tetra-ARMS PCR) and allele-specificoligonucleotide PCR (ASO-PCR) methods.Results: We found a significant difference between mean serum PAB levels and the genetic variant of rs16991615(P=0.03). ANCOVA showed a significant effect of the genotypes rs4806660 and rs10183486 on hs-CRP serum levelsin the case and control groups, respectively (P=0.04 and P=0.007). ANCOVA also showed an association betweenrs244715 genotypes and anti-hsp27 serum levels in the case group (P=0.02). There was a significant effect of thegenotypes of rs451417 on the serum hs-CRP level in the control group (P=0.03).Conclusion: There was a significant association of the genetic variants related to PM with oxidative stress and inflammatorymarkers (serum PAB, anti-hsp27 antibody, and hs-CRP). Accordingly, this seems to be an effective approach topredicting susceptible subjects for cardiovascular and mental disorders as well as various cancers

Interaction between the genetic variant of rs696217‐ghrelin and food intake and obesity and dyslipidemia

In this study, we aimed to investigate the relationship between the genetic variant of rs696217-ghrelin and fasted lipid profile, indices of obesity, and environmental parameters. Amplification refractory mutation system-polymerase chain reaction (ARMs-PCR) was used for genotyping 1118 individuals recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) cohort study. The interaction between the presence of the genetic variant of rs696217-ghrelin and nutritional intake and other major determinants of obesity and lipid profile was examined in the MASHAD study population. Individuals with the TT genotype at the locus had the lowest prevalence of obesity compared to other genotypes among the individuals. No significant relationship was found between the two groups regarding the lipid profile and TT genotype. Furthermore, no significant association was found between dietary intake and the genetic variant of rs696217-ghrelin in the population under study. Individuals with a TT or GT genotype appear to be at a higher risk of obesity, compared to those with a GG genotype. The results of the current study revealed a significant association between the genetic variant of rs696217-ghrelin and obesity; however, this gene did not correlate with the risk factors of cardiovascular diseases and dyslipidemia in the Iranian population