Global Energy Integration for Industrial Parks Incorporating Centralized Trigeneration and Interplant HEN

To address the issue of multiple forms of energy (heat, cooling, and electricity) production, distribution, and recovery, this study proposes a global energy integration method for industrial parks. The proposed method involves the construction of a centralized trigeneration system within the park, including the components of a steam power generation system, solar energy, electric boilers, organic Rankine cycle, absorption refrigeration cycle, and electric compression refrigeration. Additionally, the comprehensive utilization of waste heat from the participating plants and interplant heat exchanger network are also taken into consideration. A mixed-integer nonlinear planning mathematical model is formulated. The proposed method is demonstrated through a case study that considers both single and multiobjective (economy-environment) scenarios. It is noticed that the quantity of consumed fuel has a considerable influence on both energy distribution and park costs. Specifically, the total annualized cost increases by 44 and 5% for fuel input to 0.5 and 1.5 times the optimal natural gas amount, respectively. Moreover, the introduction of solar energy not only affects the system’s emissions but also has a substantial impact on the energy distribution

Additional file 1 of SOCS5, targeted by miR-155-5p, plays a negative regulatory role in pulmonary hypertension through inhibiting JAK2/STAT3 signaling pathway

Additional file 1: Figure S1. (A-D) RT-qPCR and western blot verification of the expression of overexpressing (A&B) or knocking down (C&D) SOCS5 in HPASMCs (results were normalized to control) (n = 3 each group)

Comparison of real-time resistance measurement and culture identification.

*<p>There is no statistical difference between the two methods (P>0.05).</p

Primers for <i>V. parahaemolyticus.</i>

<p>Primers for <i>V. parahaemolyticus.</i></p

Polarized Species in an Organic Semiconductor Laser

Meeting the challenge of direct electrically driven organic semiconductor lasers (OSLs), the design of OSL materials is being studied. Polarized species generally exist in conjugated organic materials and play an important role in the photophysics procedure; therefore, understanding these species is beneficial for designing novel OSL materials. Here, we use the amplified spontaneous emission effect as a medium to reveal a carbazole-benzothiadiazole-based polarized species induced by a charge transfer process. Spectroscopic analysis confirms that this polarized species that acted as a CT pair defect has a negative influence on the ASE stability and solid state fluorescent quantum yield. This inspires us to be cautious in terms of some specific molecular group combinations when designing OSL materials

Data_Sheet_1_From Chloroplast Biogenesis to Chlorophyll Accumulation: The Interplay of Light and Hormones on Gene Expression in Camellia sinensis cv. Shuchazao Leaves.xlsx

Chloroplast development and chlorophyll metabolism have been well described in model plants but not in perennial woody crops. Of particular interest is the interplay between light and hormones under shade conditions. We report that the shade induced accumulation of chlorophylls in Camellia sinensis cv. Shuchazao leaves is at least as a result of (a) positive changes in chloroplast development and (b) light/hormonal regulation of genes and transcription factors involved in the chlorophyll biosynthesis pathway. Under shade conditions, leaves developed an abundance of enlarged chloroplasts encapsulating more prominent thylakoid membranes. Four major metabolites in the chlorophyll biosynthesis pathway namely Chl a, Chl b, DPP, and Mg-Proto IX increased under shade conditions while PBG decreased significantly. Significant changes were found at the transcription level of regulators of chloroplast biogenesis (GLK1 and LHCB), the structural genes in the chlorophyll biosynthesis pathway (HEMA1, CLH1, PORA, and CAO) and potential components involved in light signaling (PHYA, CRY1, HY5, and DELLAs). Two central signal integrators (GLK1 and LHCB) between the nucleus and chloroplast showed clear responses to shade, suggesting a crucial role of light in regulating chloroplast development in tea leaves. Concurrent with the changes in gene expression, the concentrations of endogenous phytohormones (auxin, cytokinin, and gibberellins) increased significantly in the later stages of shade conditions. Two key integrators involved in the hormone signal pathways, EIN3 and EBF1/2, increased under shade conditions suggesting that shade induced changes to hormone levels may play some role in modulating chlorophyll biosynthesis in the tea leaves. Overall, this data suggests that the light and hormone influence over chloroplast development and chlorophyll biosynthesis in Camellia is similar to that of Arabidopsis. This study provides new insights into the molecular mechanisms that regulate chlorophyll biosynthesis in response to light and hormones in a commercially important woody plant such as Camellia, which may facilitate the breeding of high-chlorophyll tea cultivars for the improvement of sensory features of the green tea product.</p

Table_1_Clinical features and prognosis of pulmonary enteric adenocarcinoma: A retrospective study in China and the SEER database.xlsx

ObjectivePulmonary enteric adenocarcinoma (PEAC) is a rare subtype of pulmonary adenocarcinoma that lacks effective treatment. The purpose of this research was to investigate the clinical characteristics, treatment, and prognosis of PEAC, as well as the impact of relevant factors on survival, thus providing a reference for the clinical management of patients with this disease.MethodsFor this study, we gathered clinical data from 26 patients with PEAC in the Affiliated Cancer Hospital of Zhengzhou University from June 2014 to June 2021. We used SEER*Stat software V8.3.5 to download the PEAC patients from the Surveillance, Epidemiology, and End Results (SEER) database. In total, 20 patients were identified. Clinical data, including general information, imaging findings, and treatment protocols, were obtained, together with a follow-up of disease regression. The relevant clinical data were then analyzed.ResultsIt included 12 males and 14 females out of 26 patients from China, whose mean age was (62.73 ± 11.89) years; 20 were in the lower lung, 11 were stage I-II, and 15 were stage III-IV. Five had EGFR mutations, and four had KRAS mutations. In terms of treatment, patients with stage I-II were primarily treated by surgery, and patients with stage III-IV were treated mostly by chemotherapy. We extended the follow-up date to January 2022. On completion of the follow-up visit, 11 patients died, and the remaining 15 patients survived. The overall survival (OS) of 26 patients was 2.0-76.0 months, while the mean was 53.1 months, and the median OS (mOS) was 38.0 months (95% CI:1.727-74.273). In the case of progression-free survival (PFS) times, it was 2.0-76.0 months, with a mean PFS of 31.0 months and a median PFS (mPFS) of 8.0 months (95% CI:4.333-11.667). The PFS of the 15 patients in stage III-IV was 2.0-17 months, while the mean PFS was 6.5 months and the mPFS was 6.0 months (95% CI:4.512-7.488). Out of the 20 patients identified in the SEER database, the average age was 69.9 years, with 14 males and 6 females. Of these patients, 8 were diagnosed with stage I-II, while the remaining 11 were diagnosed with stage III-IV. 10 underwent surgery, 4 received radiation therapy, and 9 received chemotherapy. The mean OS of the 20 patients was 67.5 months, mOS was 28.0 months (95% CI: 9.664- 46.336). For patients diagnosed with stage III-IV, the mean OS was 14.8 months and mOS was 20 months (95% CI: 4.713-35.287).ConclusionPEAC is rare, and the prognosis is determined mainly by the stage; patients who undergo surgery in stage I-II have a better prognosis.</p

Spatial Identification of “Zeroth Defect” Formation in Organic Light-Emitting Diodes by Multispectral Mappings

In recently developed organic semiconductors, the continuously improving sample purity makes the stability of the chemical bonds of organic materials themselves become a key factor in device stability, which provides greater uncertainty for the generation of “zeroth defect”, and the spatial resolution of performance at different positions becomes particularly important. In this work, complete maps of electroluminescent, photoluminescent, and Raman scattering in the same area on an organic light-emitting diode during its operation have been achieved with a confocal spectrometer with multiple laser sources. The different spectral characters help to establish different regions and suggest the mechanism of degradation. In particular, Raman scattering has been shown to be very sensitive in a multilayer device to a change in thickness of several nanometers. In amorphous films with few defects, the very weak film uniformity, including the thickness and degree of aggregation, would induce dramatic degradation. The relatively thin and/or loosely textured region easily locally overheats and has the highest probability of “zeroth defect” generation. This method has high spatial resolution, a low level of damage to samples, good reproducibility, and multiple interconnected pieces of information, which is significant for online quality prediction and mechanistic analysis