A Study on the Origin of the Radical in Fullerene and Graphene

We reported the electron spin resonance (ESR) signal in neutral low band gap semiconductors and C₆₀ in the Li Y., J. Phys. Chem. C 2017, 121, 8579–8588. Herein, further investigation on the origin of the radical of fullerene and its derivatives was conducted, and we proposed an open-shell diradical ground state of C₆₀ and its derivatives for the first time in this work. The radicals of fullerene are usually acknowledged as their impurities or radical cations/anions. Diradical ground states in polycyclic aromatic hydrocarbons including the zethrene family and others with fused five-/six-member rings motivate us to investigate the other potential origin of the radicals of fullerene. C₆₀ has 1812 sets of resonance structures, which is the key factor to stabilize its diradicals. Numerous sets of resonance structures and excellent electron delocalization of graphene play as the key factors in stabilizing its diradicals. The previously claimed ESR-silent C₆₀ after sublimation is due to the four-member ring formation and further self-polymerization. C₆₀ with higher purity exhibited a higher ESR signal intensity, and this further confirmed that the ESR might not come from the impurity. Previously published work confirmed the radical is not from a radical cation/anion; our proposal of the radical of fullerene is reasonable in understanding its basic properties. Moreover, the radical origin of graphene is also proposed similarly

Aggregation of a Polyphilic Janus Polythiophene in Solution

Solutions of poly(4‘-perfluorooctyl-3-octyl-2,2‘-bithiophene) display strong thermochromism and solvatochromism that are consistent with formation of solid-state-like aggregates. The polyphilicity of the structure (having alkyl, fluoroalkyl, and arene segments) provides a Janus structure in which the two edges of a ribbonlike polymer chain have distinctly different surface energies. In addition, the placement of electron-donating and electron-withdrawing substituents provides an alternation of charge density along the polymer backbone. The chromic effects are not observed for analogous polymers that only have one type of side chain or for an analogue with alternating alkyl and semifluoroalkyl side chains that is polyphilic but does not have the alternation of charge density along the polymer chain

Supplemental Material, Editing_Certificate - A novel BEMD-based method for forecasting tourist volume with search engine data

Supplemental Material, Editing_Certificate for A novel BEMD-based method for forecasting tourist volume with search engine data by Ling Tang, Chengyuan Zhang, Tingfei Li and Ling Li in Tourism Economics</p

Mechanistic Investigation of the Cobalt-Catalyzed Selective Conversion of Diallylanilines to Quinolines Involving C−N and C−H Activations

2,3-Substituted quinolines were readily prepared from diallylanilines in good yields under mild conditions by using Co2(CO)8 as catalyst., Regioselectivity has been explored by examining a series of electron-donating and electron-withdrawing functional groups at ortho, meta, and para positions of the diallylanilines. The results show that both steric and electronic effects influence the isolated yields. Electron-withdrawing groups inhibit the reaction. Solvent effects, temperature effects, and catalyst loadings have also been investigated. Isotopic labeling experiments were devised to permit delineation of the mechanism of reaction

Supplementary-R1 - A novel BEMD-based method for forecasting tourist volume with search engine data

Supplementary-R1 for A novel BEMD-based method for forecasting tourist volume with search engine data by Ling Tang, Chengyuan Zhang, Tingfei Li and Ling Li in Tourism Economics</p

Image_2_Downregulationof circ_0001578 promotes gestational diabetes mellitus by inducing placental inflammation via the NF-κB and JNKs pathways.jpeg

Gestational diabetes mellitus (GDM) is one of the most common diseases during pregnancy. Some patients with GDM have adverse pregnancy outcomes. However, the pathogenesis of GDM is very complex and not well understood. In this study, we characterized the expression and functions of a circular RNA, circ_0001578, in GDM. In particular, using qRT-PCR, we verified previous RNA-seq results showing that circ_0001578 is significantly downregulated in the placental villous tissues of pregnant women with GMD. We demonstrated that plasma exosome circ_0001578 expression in the second trimester effectively predicts GDM at 28 weeks. Furthermore, in HTR-8/SVneo trophoblasts, the downregulation of circ_0001578 inhibited proliferation and migration and induced apoptosis. These changes may induce chronic inflammation in the placenta. These effects of circ_0001578 downregulation may be mediated by the upregulation of the NF-κB and JNK pathways, combined with increased expression levels of IL-1, IL-6, IL-8, TNF-α, and CRP. Collectively, the downregulation of circ_0001578 may promote GDM by inducing chronic inflammation in the placenta via the NF-κB and JNK pathways. Furthermore, our findings support that circ_0001578 has potential to serve as an early marker of GDM.</p

Few-layer hyperbolic multilayer for spontaneous emission enhancement

Multilayer hyperbolic metamaterials consisting of alternating metal and dielectric layers have important applications in spontaneous emission enhancement. In contrast to the conventional choice of at least dozens of layers in multilayer structures to achieve tunable Purcell effect on quantum emitters, our numerical calculations reveal that multilayers with fewer layers and thinner layers would outperform in Purcell effect. These discoveries are attributed to the negative contributions by an increasing layer number to the imaginary part of the reflection coefficient, and the stronger coupling between surface plasmon polariton modes on a thinner metal layer. This work could provide fundamental insights and practical guide for optimizing the local density of optical states enhancement functionality of ultrathin and even two-dimensional photon sources

2-DE maps of <i>I</i>. <i>galbana</i> in N-deprived L₁ and L₁ media.

<p>(A-C), sample of control collected at day 0, 2 and 6 respectively. (D-F), N-deprived samples for day 0, 2 and 6. The protein samples were separated by SDS-PAGE using a 12% gel, following IEF. The gels were stained with CBB G-250. The straight lines denote the positions of the changed proteins on the 2^nd day in N-deprived <i>I</i>. <i>galbana</i>. The replicate 2DE maps on the 2^nd day are seen in the Figure S1.</p

Image_1_Downregulationof circ_0001578 promotes gestational diabetes mellitus by inducing placental inflammation via the NF-κB and JNKs pathways.jpeg

Gestational diabetes mellitus (GDM) is one of the most common diseases during pregnancy. Some patients with GDM have adverse pregnancy outcomes. However, the pathogenesis of GDM is very complex and not well understood. In this study, we characterized the expression and functions of a circular RNA, circ_0001578, in GDM. In particular, using qRT-PCR, we verified previous RNA-seq results showing that circ_0001578 is significantly downregulated in the placental villous tissues of pregnant women with GMD. We demonstrated that plasma exosome circ_0001578 expression in the second trimester effectively predicts GDM at 28 weeks. Furthermore, in HTR-8/SVneo trophoblasts, the downregulation of circ_0001578 inhibited proliferation and migration and induced apoptosis. These changes may induce chronic inflammation in the placenta. These effects of circ_0001578 downregulation may be mediated by the upregulation of the NF-κB and JNK pathways, combined with increased expression levels of IL-1, IL-6, IL-8, TNF-α, and CRP. Collectively, the downregulation of circ_0001578 may promote GDM by inducing chronic inflammation in the placenta via the NF-κB and JNK pathways. Furthermore, our findings support that circ_0001578 has potential to serve as an early marker of GDM.</p

DataSheet_1_N6-Methyladenosine-Related Gene Signature Associated With Monocyte Infiltration Is Clinically Significant in Gestational Diabetes Mellitus.pdf

ObjectiveThe objective of this study was to reveal the potential crosstalk between immune infiltration and N6- methyladenosine (m6A) modification in the placentas of patients with gestational diabetes mellitus (GDM), and to construct a model for the diagnosis of GDM.MethodsWe analyzed imbalanced immune infiltration and differentially expressed m6A-related genes (DMRGs) in the placentas of patients with GDM, based on the GSE70493 dataset. An immune-related DMRG signature, with significant classifying power and diagnostic value, was identified using a least absolute shrinkage and selection operator (LASSO) regression. Based on the selected DMRGs, we developed and validated a nomogram model using GSE70493 and GSE92772 as the training and validation sets, respectively.ResultsInfiltration of monocytes was higher in GDM placentas than in control samples, while the infiltration of macrophages (M1 and M2) in GDM placentas was lower than in controls. A total of 14 DMRGs were strongly associated with monocyte infiltration, seven of which were significant in distinguishing patients with GDM from normal controls. These genes were CD81, CFH, FABP5, GBP1, GNG11, IL1RL1, and SLAMF6. The calibration curve, decision curve, clinical impact curve, and receiver operating characteristic curve showed that the nomogram recognized GDM with high accuracy in both the training and validation sets.ConclusionsOur results provide clues that crosstalk between m6A modification and immune infiltration may have implications in terms of novel biomarkers and therapeutic targets for GDM.</p