Pragmatic guidance for IPD systematic reviews and meta-analyses of intervention effects based on randomised trials.

<p>Pragmatic guidance for IPD systematic reviews and meta-analyses of intervention effects based on randomised trials.</p

Relative risks and p values for the interaction between treatment and categorical covariates using one and two-stage models.

<p>The two-stage model with fixed-effect replicating the analysis of <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0046042#pone.0046042-Askie1" target="_blank">[29]</a>. One-stage models were consistent whether treatment effects were fixed or random.</p

Forest plot of relative risks of developing pre-eclampsia (fixed-effect inverse variance model based on two-stage analysis replicating the analysis of [<b>29</b>]).

<p>Q(df = 23) = 31.19, p = 0.12, I² = 26.3.</p

Tradeoffs between analytical, computational and statistical complexity, ability to minimise potential bias and provide insights into treatment-covariate interactions.

<p>Tradeoffs between analytical, computational and statistical complexity, ability to minimise potential bias and provide insights into treatment-covariate interactions.</p

Comparison of one-stage models including interaction between antiplatelets and presence of a high-risk factor.

<p>Comparison of one-stage models including interaction between antiplatelets and presence of a high-risk factor.</p

Relative risk and p value for treatment-covariate interactions for continuous covariates.

<p>Relative risk and p value for treatment-covariate interactions for continuous covariates.</p

Maternal secondary outcomes^*.

<p>Maternal secondary outcomes^{<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002398#t008fn002" target="_blank">*</a>}.</p

Treatment effects among the subgroups considered by dose actually received.

<p>Treatment effects among the subgroups considered by dose actually received.</p