A Review of Subthreshold Micropulse Laser for Treatment of Macular Disorders

Article full text The full text of this article can be found here. Provide enhanced digital features for this article If you are an author of this publication and would like to provide additional enhanced digital features for your article then please contact [email protected]. The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. Other enhanced features include, but are not limited to: • Slide decks • Videos and animations • Audio abstracts • Audio slides</p

Univariate regression analysis for SNPs rs10490924 in ARMS2 and rs1061170 in CFH in patients with unilateral nAMD and different severity stages of the fellow-eye.

<p>Univariate regression analysis for SNPs rs10490924 in ARMS2 and rs1061170 in CFH in patients with unilateral nAMD and different severity stages of the fellow-eye.</p

Multivariate regression model for each severity stage with results for SNPs rs10490924 in <i>ARMS2</i> and rs1061170 in <i>CFH</i> (data of other SNPs is shown in S3 Table).

<p>Multivariate regression model for each severity stage with results for SNPs rs10490924 in <i>ARMS2</i> and rs1061170 in <i>CFH</i> (data of other SNPs is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0156778#pone.0156778.s003" target="_blank">S3 Table</a>).</p

Distribution of single nucleotide polymorphisms rs10490924 in <i>ARMS2</i> and rs1061170 in <i>CFH</i> and trend test of AMD severity stages (data of other SNPs is shown in S1 Table).

<p>Distribution of single nucleotide polymorphisms rs10490924 in <i>ARMS2</i> and rs1061170 in <i>CFH</i> and trend test of AMD severity stages (data of other SNPs is shown in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0156778#pone.0156778.s001" target="_blank">S1 Table</a>).</p

Area under the curve (AUC) of risk models in different AMD severity stages.

<p>Area under the curve (AUC) of risk models in different AMD severity stages.</p

Grading results.

<p>Grading results.</p

Demographics.

<p>Demographics.</p

Hyperreflective foci on SD-OCT before and after treatment with anti-VEGF.

Foveal centered spectral domain optical coherence tomography (SD-OCT) B-scan image of a patient with DME before (A) and after (B) 3 injections with anti-VEGF. Black arrows indicate hyperreflective foci, within 3000 μm of the fovea (dashed bars).</p

Linear mixed model analysis of the effect of baseline number of HF on baseline values of VA and CRT, and VA and CRT changes.

Linear mixed model analysis of the effect of baseline number of HF on baseline values of VA and CRT, and VA and CRT changes.</p

Difference in number of HF at baseline, and change in HF between eyes with adequate response versus insufficient response.

Mean number of HF at baseline in groups based on insufficient and adequate CRT response (A); insufficient and adequate VA response (B); and insufficient and adequate combined CRT + VA response (C). Mean change in number of HF in groups based on insufficient and adequate CRT response (D); insufficient and adequate VA response (E); and insufficient and adequate combined CRT + VA response (F). The distribution of HF in the inner and outer retinal layers is displayed as a percentage. The values represent the odds ratio with corresponding 95% confidence interval and p-value. The odds ratio of adequate response is 1.106, which can be interpreted as an increase, or chance, for adequate response by 10.6% for every HF at baseline; when the number of HF at baseline increases by 10, the chance for adequate response increases exponentially by 1.10610 = 2.74 or 274%. The bars represent mean ± 95% confidence interval and are based on descriptive statistics. *P<0.05.</p