22 research outputs found

    Changes in diffusion tensor imaging (DTI) indices of white matter microstructure after sleep deprivation and associations with sleepiness.

    No full text
    <p>(<b>A</b>) Significant decreases in fractional anisotropy (FA) after sleep deprivation (blue colors; left panel). (<b>B</b>) Significant decreases in axial diffusivity (AD) after sleep deprivation (blue colors; left panel). Averaged DTI values at time point (TP)2 and TP3 across significant voxels are shown for each participant using individual colors in the right panels of (<b>A</b>) and (<b>B</b>). Values from the same participant are connected with a line. (<b>C</b>) No significant relationship was observed between the decrease in FA in the voxels shown in (<b>A</b>) and Stanford Sleepiness Scale (SSS) score at TP3 (<i>R</i> = −0.33, <i>P</i> = 0.14). (<b>D</b>) Because the FA decreases in the significant voxels of (<b>A</b>) were mainly driven by AD reductions, we examined whether reductions in averaged AD within these clusters correlated with SSS score and found a significant negative association (<i>R</i> = −0.63, <i>P</i> = 0.002), indicating greater sleepiness in subjects with larger AD reductions after sleep deprivation. (<b>E</b>) No significant relationship was found between AD reductions across the voxels shown in (<b>B</b>) and SSS score (<i>R</i> = −0.26, <i>P</i> = 0.265). (<b>F,G</b>) Averaged AD across all voxels of the white matter skeleton decreased significantly from TP2 to TP3; this decrease was significantly correlated with sleepiness at TP3 (<i>R</i> = −0.65, <i>P</i> = 0.001). The left side of the brain images represents the right hemisphere.</p

    Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.

    No full text
    <p>Abbreviations: BD, bipolar disorder; HC, healthy controls; SD, standard deviation; WASI, Wechsler Abbreviated Scale of Intelligence; IDS, Inventory of Depressive Symptoms; YMRS, Young Mania Rating Scale; PANSS P score, Positive and Negative Syndrome Scale positive subscale; GAF-S, Global Assessment of Functioning–symptom score; GAF-F, Global Assessment of Functioning–function score; BD PGRS, bipolar disorder polygenic risk score; ms, milliseconds.</p><p>BD PGRS values are reported as z-scores (with SD in brackets).</p><p>Complete behavioral data (response times and accuracy rates per condition) were available for 80/85 BD and 119/121 HC. For the remaining individuals (5 BD, 2 HC), an accuracy rate for each session (i.e. a combined rate for negative faces and shapes, and for positive faces and shapes) was available and was used to confirm that the participants paid attention to the task (accuracy rate: 97.4% and 96.0%, respectively).</p><p><sup>a</sup> Mean age at fMRI scanning. Age range was 18 to 63.</p><p><sup>b</sup> IDS score at scanning was available for 60/85 individuals (70.6%).</p><p><sup>c</sup> YMRS score at scanning was available for 69/85 individuals (81.2%).</p><p><sup>d</sup> PANSS P score at scanning was available for 38/85 individuals (44.7%).</p><p><sup>e</sup> Last six months</p><p>Demographic data and clinical characterization of individuals participating in a faces matching functional MRI study.</p

    Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.

    No full text
    <p>*Remains significant after Bonferroni correction (8 independent tests)</p><p><sup>#</sup>P < 0.05 with IQ and education in model</p><p>Abbrevations: Pos, Positive; Neg, Negative; HC, healthy controls; BD, bipolar disorder; PGRS, polygenic risk score; L, left; R, right. ‘+’, positively associated; ‘-’, negatively associated.</p><p>Coordinates are given in MNS space.</p><p>Significant clusters at whole-brain level for diagnostic category and polygenic risk score analyses, corrected for sex and age.</p

    A matrix of plots illustrating the agreement of HRV between three time points.

    No full text
    <p>The upper right panels consist of scatterplots with identity line (45° line though the origin). The lower left panels consist of Bland-Altman plots with confidence bounds and bias (dotted red line) and the horizontal black line passing through the origin. The confidence bounds show the mean of the difference between time points plus or minus twice of the standard deviation of the difference.</p
    corecore