Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction in Water Using Cyclodextrin as a Phase Transfer Catalyst

1,4-Disubstituted-1,2,3-triazoles were obtained in excellent yields from azides and terminal alkynes in H₂O in the presence of catalytic amount of β-cyclodextrin as a phase transfer catalyst. Also, a one-pot CuAAC reaction was carried out successfully, affording 1,4-disubstituted-1,2,3-triazoles in good to high yields starting from an alkyl bromide, sodium azide, and terminal alkyne

Do episodic self- and partner-uncertainty mediate the association between attachment orientations and emotional responses to relationship-threatening events in dating couples?

<p>This study examined relational-uncertainty perceptions (a form of cognitive appraisal) to investigate how partners in 272 heterosexual couples responded emotionally to a relationship-challenging event. Participants rated themselves on attachment anxiety and avoidance. Then, after listing a challenging event, they rated how uncertain it made them about their own and their partner's continued involvement in the relationship. Participants also rated how angry and fearful the event made them. An Actor-Partner Interdependence Model yielded three sets of results. First, actor effects from insecure attachment orientations to episodic relational uncertainty emerged. Second, proposed mediation between attachment orientations and emotional reactions by uncertainty was partially supported (perceived partner-uncertainty partially mediated the positive association of anxious attachment and fear, and self-uncertainty partially mediated the positive relation between avoidant attachment and anger). Finally, a partner effect was found between one couple member's avoidant attachment and the other's perceived partner uncertainty. Men and women exhibited similar findings.</p

Additional file 1: of Bioassay-guided isolation of active anti-adipogenic compound from royal jelly and the study of possible mechanisms

Data on identification and purity assessment of isolated 10-Hydroxy-2-decenoic acid (10-HDA). Figure S1. 1H NMR Spectrum (A) and 13C NMR (500 MHz) spectra (B) of the compound isolated from ethyl acetate fraction of RJ in DMSO-d6; Figure S2. TLC analysis of Royal jelly (RJ), RJ-EA fraction (EA), isolated 10-HDA compound (Com) and standard 10-HDA (Std); Figure S3. Mass spectrometry - structure of the 10-Hydroxy-2-decenoic acid (10-HDA). (DOCX 156 kb

DataSheet1_18KHT01, a Potent Anti-Obesity Polyherbal Formulation.docx

Obesity is a life-threatening metabolic disorder necessitating urgent development of safe and effective therapy. Currently, limited such therapeutic measures are available for obesity. The present study was designed to develop a novel, safe and effective herbal therapy for the management of obesity. A polyherbal formulation (18KHT01) was developed by homogeneously mixing a specific proportion of crude Quercus acutissima (acorn jelly powder), Camellia sinensis (dry leaf buds), and Geranium thunbergii (dry aerial part) along with Citrus limon (fruit juice). Synergistic antioxidant, antiadipogenic, and anti-obesity activities were evaluated by in vitro as well as in vivo studies. In vitro experiments revealed strong synergistic antioxidant and anti-adipogenic activities of 18KHT01. Molecular assessment of 18KHT01 showed significant down-regulation of vital adipogenic factors such as PPARγ, C/EBPα, aP2, SREBP-1c, FAS, and LPL. Based on the results of the preliminary toxicity study, 75 and 150 mg/kg, twice daily doses of 18KHT01 were administered to evaluate anti-obesity activity in diet-induced obese (DIO) C57BL/6J mice model. The major obesity-related parameters such as body weight, weight gain, food efficiency ratio, as well as serum lipid profile were significantly reduced by 18KHT01 with potential synergism. Also, the high-fat diet-induced insulin resistance was suggestively alleviated by the formulation, and thus ameliorated fasting blood glucose. Histological evaluation of liver and white adipose tissue revealed that the significant reduction of fat depositions and thus reduction of these tissue weights. Synergy evaluation experiments exhibited that the 18KHT01 offered strong synergism by improving efficacy and reducing the toxicity of its ingredients. Overall results evidenced the 18KHT01 as a safe and potent anti-obesity herbal therapy.</p