Occurrence of EBV DNA and periodontopathic bacteria in the subgingival samples from HC and patients with CP.

<p>Statistically significant; <i>P</i><0.01**, <i>P</i><0.05*; HC, healthy controls; CP, chronic periodontitis.</p

Association between EBV and chronic periodontitis.

<p>CP, chronic periodontitis; PD, probing depth.</p

Quality estimation of influenza A H7N9 hemagglutinin homology models generated.

<p>Ribbon structure and model quality estimation of a (A) representative avian and (B) novel human H7N9 HA homology models. QMEAN score is indicated below. QMEAN scores > 0.5 are considered reliable. α-helix (red), ß-sheet (yellow), and structural loops (white) are indicated.</p

Detection of EBER in inflamed gingival connective tissue of patients with chronic periodontitis.

<p>Serial sections of periodontitis lesion were stained with HE (a), EBER ISH (b) and (c) anti CD19 antibody, respectively. Original magnification; x200.</p

HA homology models of the 2003 H7N7 and 2013 H7N9 human strains are structurally similar.

<p>(A) Ribbon structure and model quality estimation of a representative 2003 H7N7 human HA homology model. QMEAN score is indicated below. QMEAN scores > 0.5 are considered reliable. α-helix (red), ß-sheet (yellow), and structural loops (white) are indicated. HA homology model superimposition of the representative (B) 2003 H7N7 human and 2011 H7N9 avian strains, and (C) 2003 H7N7 and 2013 H7N9 human strains. HA homology models of the 2003 H7N7 (violet), 2011 H7N9 (blue), and 2013 (pink) strains are shown. Non-overlapping regions representing structural differences (shaded in gray) are indicated. RMSD scores of the superimposed Cα backbone are indicated below. RMSD scores close to 0 would insinuate low structural difference between the homology models.</p

Average PD and frequency of BOP in patients with chronic periodontitis with a PD of ≥5 mm.

<p>PD, probing depth; BOP, bleeding on probing.</p

Patient characteristics.

<p>Healthy controls (HC); Chronic periodontitis (CP); PD, probing depth;</p><p>BOP, bleeding on probing.</p

Pattern-2 structural difference is associated with the absence of the R141₁:D77₁ salt bridge.

<p>Distance measurement between R141₁ (orange) and D77₁ (maroon) found in the (A) 2008b and (B) 2013 HA homology models. All amino acid residues indicated are in a wireframe structure. All measurements are indicated in Å. HA structural difference is shaded in gray.</p

H7N9 human HA homology model has two patterns of structural differences with avian HA homology models.

<p>H7N9 HA homology model superimposition of the (A) 2008b and 2011 strains, (B) 2011 and 2013 strains, and (C) 2008b and 2013 strains. HA homology models of the 2008b (gray), 2011 (blue), and 2013 (pink) strains are shown. Non-overlapping regions representing structural differences (shaded in gray) are indicated. RMSD scores of the superimposed Cα backbone are indicated below. RMSD scores close to 0 would insinuate low structural difference between the homology models.</p

Pattern-1 structural differences are ascribable to salt bridge formation involving amino acid residue 114₁.

<p>Distance measurements of amino acid residues 262₁, 264₁, and 265₁ (green) relative to residue 114₁ (violet) found in the (A) 2011 and (B) 2013 HA homology models. All amino acid residues indicated are in a wireframe structure. All measurements are indicated in Å. Interrelationship of HA structural differences (shaded in gray) observed in the (C,E) 2011 and (D,F) 2013 HA homology models are highlighted in green. Amino acid residue 114₁ is indicated in violet.</p