Development and Identification of Metrics to Predict the Impact of Dimension Reduction Techniques on Classical Machine Learning Algorithms for Still Highway Images

We are witnessing an influx of data - images, texts, video, etc. Their high dimensionality and large volume make it challenging to apply machine learning to obtain actionable insight. This thesis explores several aspects pertaining to dimensional reduction: dimension reduction methods, metrics to measure distortion, image preprocessing, etc. Faster training and inference time on reduced data and smaller models which can be deployed on commodity hardware are a critical advantage of dimension reduction. For this study, classical machine learning methods were explored owing to their solid mathematical foundation and interpretability. The dataset used is a time series of images from several camera feeds observing the traffic, weather and road conditions along highways. The time-series nature of dataset gives rise to interesting questions which are investigated in this work. For instance, can machine learning models trained on past data be used on future camera feed data? This is highly desirable and yet difficult due to the changing weather, road conditions, traffic conditions and scenery. Can dimension reduction models obtained from past data be used for reducing dimensionality of future data? This thesis also examines the difference between the performance of machine learning methods before and after application of dimension reduction. It tests some existing metrics to measure quality of dimension-reduced data set and introduces several new ones. It also examines the application of image pre-processing methods to boost the performance of classifiers. The classification performance with and without random sampling has been studied as well

True prevalence of twin HDV-HBV infection in Pakistan: a molecular approach

Hepatitis Delta Virus (HDV) infects only patients that are already infected by hepatitis B virus (HBV) because this is sub satellite virus which depends on and propagate only in the presence of HBV. HDV causes co-infection or super infection with sever complication as compared to only HBV infection. No study on molecular level on HDV is available from this region; therefore, the aim of this study was to found out the molecular epidemiology of HDV (as a co-infection with HBV) in different geographical regions of Pakistan

Development of a STEP-compliant design and manufacturing framework for discrete sheet metal bend parts

Metal sheets have the ability to be formed into nonstandard sizes and sections. Displacement-controlled computer numerical control press brakes are used for three-dimensional sheet metal forming. Although the subject of vendor neutral computer-aided technologies (computer-aided design, computer-aided process planning and computer-aided manufacturing) is widely researched for machined parts, research in the field of sheet metal parts is very sparse. Blank development from three-dimensional computer-aided design model depends on the bending tools geometry and metal sheet properties. Furthermore, generation and propagation of bending errors depend on individual bend sequences. Bend sequence planning is carried out to minimize bending errors, keeping in view the available tooling geometry and the sheet material properties’ variation. Research reported in this article attempts to develop a STEP-compliant, vendor neutral design and manufacturing framework for discrete sheet metal bend parts to provide a capability of bidirectional communication between design and manufacturing cycles. Proposed framework will facilitate the use of design information downstream at the manufacturing stage in the form of bending workplan, bending workingsteps and a feedback mechanism to the upstage product designer. In order to realize this vendor neutral framework, STEP (ISO 10303), AP203, AP207, and AP219 along with STEP-NC (ISO14649) have been used to provide a basis of vendor neutral data modeling.N/

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Frequency of Metabolic Syndrome in Patients with Type 2 Diabetes Mellitus

Abstract Background: The management of renal stones has undergone significant advancements in recent years, with percutaneous nephrolithotomy (PCNL) and Retrograde Intrarenal Surgery (RIRS) emerging as minimally invasive alternatives to traditional Pyelolithotomy. This study aims to assess the effectiveness of Mini-PCNL and RIRS for renal stones measuring 1-2 cm, focusing on operative time, stone clearance, hospital stay, and the need for ancillary procedures. Methodology: This retrospective study collected data from the medical records of patients admitted to The Department of Urology at The Kidney Centre, Karachi, between January 1, 2021, and August 31, 2022. The study included 100 patients who underwent RIRS and 129 patients who underwent Mini-PCNL. Results: It was found that the operative time was statistically similar in both groups. However, the length of hospital stay was significantly higher in the Mini-PCNL group (more than 2 days in 88.4%), whereas in the RIRS group, the majority of patients stayed ≤ 2 days (78%). Overall stone clearance was 82.1%, with a slightly higher clearance rate in patients who underwent Mini-PCNL (85.3%) compared to RIRS (78%), though the p- value was not statistically significant. Conclusion: For renal stones sized 1-2 cm, both RIRS and Mini-PCNL demonstrate efficient treatment options with comparable stone-free rates. RIRS appears more comfortable and less morbid than Mini-PCNL, with a shorter hospital stay. Although Mini-PCNL requires an extended hospital stay to treat 1- to 2-cm renal stones, it is associated with fewer complications and a reduced need for a JJ stent, making it a viable alternative to RIRS in certain cases

Energy Consumption in Agriculture Sector, Environmental Cleanliness and Economic Growth: An Empirical Evidence of South Asian Countries

This study plays its role in the literature by investigating the impact of energy consumption on agriculture sector, and environmental cleanliness on Gross Domestic Product, in five South Asian countries from the period of 1990 to 2015. Energy is now becoming a challenge for the South Asian countries especially country like Pakistan. Developing countries are in a race to gather more and more resource for the production of energy. The main objective of research is to examine the short-run and long-run relationship between economic growth and energy consumption on agriculture sector of economy in South Asian countries. Granger causality test and Error correction model is employed to get the results. The empirical results showed the presence of co-integration among the variables and it indicates gross domestic product has a positive relationship with energy consumption in agriculture sector and environmental cleanliness. Granger causality results showed that unidirectional causality is present between gross domestic product and agricultural sector while no causality is present among environment cleanliness. &nbsp

GIS-based assessment of groundwater vulnerability to heavy metal contamination via water quality pollution indices in urban Aligarh, India

The study presents an assessment of groundwater vulnerability due to heavy-metal contamination using Heavy Metal Pollution and Contamination Index of Urban Aligarh. Globally, hazardous compounds in industrially contaminated sites are pressing and high-priority issue. A detailed risk assessment was carried out to determine the potential health hazards linked to locations that were recently polluted. A total of 17 groundwater samples were taken from hand-pump and 20 industrial drainage samples were collected from selected areas of Aligarh. The concentration of heavy-metals in the collected samples analyzed were shown on maps using ArcGIS software and interpreted for Heavy Metal Pollution Index (HPIx) and Contamination Index (CDx). These analyzed values were subsequently compared with the permissible limits established by the agencies like EPA, WHO, and BIS. The mean concentration of heavy-metals in groundwater of different locations was observed as follows particular sequence: Ni (1.40), Cu (0.58), Zn (0.06), Fe (0.08), Mn (0.04), Cr (0.001), Pb (0.00025) mg/l. Additionally in industrial effluent, Cr (18.3), Ni (13.34), Mn (1.16), Cu (1.99), Pb (1.2), Fe (6.3), Zn (0.51) mg/l. According to HPIx, the analysis reveals 64.7%, of visited areas belonged to have safe groundwater. Conversely, a smaller proportion, 35.3%, was found falling into heavy metal-polluted group. HIGHLIGHTS The study provides a comprehensive assessment of heavy metal contamination.; GIS-driven vulnerability mapping is conducted in the study.; The study includes an evaluation of real-world impact.; The study systematically validates scientific indices for accuracy and reliability.; The study investigates health effects resulting from heavy metal contamination.; A comprehensive analysis of drinking water quality.

Effect of dietary inclusion of taurine on performance, carcass characteristics and muscle micro-measurements in broilers under cyclic heat stress

In the past, taurine was not considered essential in poultry diet; however, heavy reliance on plants derived feed ingredients and environmental stresses have compelled its application inevitable. Six hundred day old male broilers (Hubbard) were supplementation with taurine at the level of 0 (TAN0), 2.5 (TAN2.5), 5 (TAN5) and 7.5 g/kg (TAN7.5) in drinking water during heat stressed conditions for a period of 35 days. On overall basis, feed intake was not significantly (p>.05) different between the treatments. At the end of the experiment, weight gain was significantly (p<.05) higher in the treatment groups. On the overall basis, FCR was significantly (p<.01) lower in the treatment groups. Abdominal fat weight was significantly (p<.01) lower in TAN5 and TAN7.5 compared to the control group. On the slaughter age (35 days) muscle fibre diameter (MFD), muscle fibre cross sectional area (MFCSA), muscle fascicle diameter (MFASD) and muscle fascicle cross-sectional area were significantly (p<.05) higher in TAN7.5 compared to the control. The results indicated that growth performance was enhanced in taurine supplemented birds irrespective of the inclusion levels during the heat stress. Abdominal fat was significantly decreased in TAN5 and TAN7.5 levels; however, muscle histological features were significantly higher in all treatment groups