High-efficient harmonic vortex generation from a laser irradiated hollow-cone target

It has been recently reported that ultraviolet harmonic vortices can be produced when a high-power circular-polarized laser pulse travels through a micro-scale waveguide. However, the harmonic generation quenches typically after a few tens of microns of propagation, due to the build-up of electrostatic potential that suppresses the amplitude of the surface wave. Here we propose to utilize a hollow-cone channel to overcome this obstacle. When traveling in a cone target, the laser intensity gradually increases, allowing the surface wave to maintain a high amplitude for a much longer distance. The harmonic vortices can be produced with very high efficiency. According to three-dimensional particle-in-cell simulations, the overall efficiency are boosted by almost one order of magnitude, reaching $>20\%$. It is also found that using the cone targets can mitigate efficiency decline due to pre-heating of plasma by laser prepulse. The proposed scheme paves the way to the development of powerful optical vortices sources in the extreme ultraviolet regime - an area of significant fundamental and applied physics potential

Intense high-harmonic optical vortices generated from a micro-plasma-waveguide irradiated by a circularly polarized laser pulse

A scheme for generating intense high-harmonic optical vortices is proposed. It relies on spin-orbit interaction of light when a relativistically-strong circularly polarized laser pulse irradiates a micro-plasma-waveguide. The intense laser field drives a strong surface wave at the inner boundary of the waveguide, which leads to high-order harmonic generation as the laser traveling inside. For a circularly polarized drive laser, the optical chirality is imprinted to the surface wave, which facilitates conversion of spin angular momentum of the fundamental light into orbital angular momenta of the harmonics. A "shaken waveguide" model is developed showing that the aforementioned phenomena arises due to nonlinear plasma response that modifies electromagnetic mode at high intensities. We further show the phase velocities of all the harmonic beams are automatically matched to the driving laser, so that the harmonic intensities increase with propagation distance. The efficiency of harmonic production are related to the surface wave breaking effect, which can be significantly enhanced using a tightly focused laser. Our simulation suggests an overall conversion efficiency $\sim5\%$ can be achieved

Project double-generation network plan.

Project double-generation network plan.</p

Algorithm comparison results.

Algorithm comparison results.</p

Table_2_New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease.xlsx

BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA disease are not clear. In this study, we used bioinformatics to investigate the roles of circadian rhythm disruption and immune microenvironments in OSA.MethodsWe analyzed differential genes and their associated functional pathways in the circadian rhythm-associated OSA dataset, then regrouped OSA samples using the differential genes and explored differences in immune cell infiltration between the two different subgroups. Meanwhile, we used two machine learning algorithms to further define circadian rhythm-related signature genes and to explore the relationship between key genes and immune cell infiltration. Finally, we searched for the transcription factors of the key differential gene JUN.ResultsWe screened 15 circadian rhythm-related differential genes in the OSA-related dataset and further defined 3 signature genes by machine learning algorithms. Immunoassays showed a significant increase in resting mast cell infiltration and a decrease in monocyte infiltration in the OSA group. The results of our animal experiments also confirmed that the expression of these 3 key genes, as well as the immune cell infiltration, showed a trend consistent with the results of the bioinformatics analysis.ConclusionsIn conclusion, this study reveals the interaction between circadian rhythm disruption and immune infiltration in OSA, providing new insights into the potential pathogenesis of OSA.</p

Mechanism of particle movement in space.

Mechanism of particle movement in space.</p

Relevant parameters of each activity.

Relevant parameters of each activity.</p

Table_3_New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease.xls

BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA disease are not clear. In this study, we used bioinformatics to investigate the roles of circadian rhythm disruption and immune microenvironments in OSA.MethodsWe analyzed differential genes and their associated functional pathways in the circadian rhythm-associated OSA dataset, then regrouped OSA samples using the differential genes and explored differences in immune cell infiltration between the two different subgroups. Meanwhile, we used two machine learning algorithms to further define circadian rhythm-related signature genes and to explore the relationship between key genes and immune cell infiltration. Finally, we searched for the transcription factors of the key differential gene JUN.ResultsWe screened 15 circadian rhythm-related differential genes in the OSA-related dataset and further defined 3 signature genes by machine learning algorithms. Immunoassays showed a significant increase in resting mast cell infiltration and a decrease in monocyte infiltration in the OSA group. The results of our animal experiments also confirmed that the expression of these 3 key genes, as well as the immune cell infiltration, showed a trend consistent with the results of the bioinformatics analysis.ConclusionsIn conclusion, this study reveals the interaction between circadian rhythm disruption and immune infiltration in OSA, providing new insights into the potential pathogenesis of OSA.</p

Table_1_New insights from integrated bioinformatics analysis: the role of circadian rhythm disruption and immune infiltration in obstructive sleep apnea disease.xlsx

BackgroundCircadian rhythm disruption and immune infiltration are both closely associated with the development of Obstructive sleep apnea (OSA) disease and a variety of cardiovascular and neurological complications, but their interactions with OSA disease are not clear. In this study, we used bioinformatics to investigate the roles of circadian rhythm disruption and immune microenvironments in OSA.MethodsWe analyzed differential genes and their associated functional pathways in the circadian rhythm-associated OSA dataset, then regrouped OSA samples using the differential genes and explored differences in immune cell infiltration between the two different subgroups. Meanwhile, we used two machine learning algorithms to further define circadian rhythm-related signature genes and to explore the relationship between key genes and immune cell infiltration. Finally, we searched for the transcription factors of the key differential gene JUN.ResultsWe screened 15 circadian rhythm-related differential genes in the OSA-related dataset and further defined 3 signature genes by machine learning algorithms. Immunoassays showed a significant increase in resting mast cell infiltration and a decrease in monocyte infiltration in the OSA group. The results of our animal experiments also confirmed that the expression of these 3 key genes, as well as the immune cell infiltration, showed a trend consistent with the results of the bioinformatics analysis.ConclusionsIn conclusion, this study reveals the interaction between circadian rhythm disruption and immune infiltration in OSA, providing new insights into the potential pathogenesis of OSA.</p