Activated cluster for the contrast ergometry sweat odor > TSST sweat odor (Fig. 3a).

<p>The contrast is displayed for the comparison of patients with PD and healthy controls (K≥10, p<.05). Patients showed more activation in the left cingulate cortex than healthy controls. Activated cluster for the contrast TSST sweat odor > ergometry sweat odor (Fig. 3b). Patients showed more activation in the right inferior frontal gyrus than healthy controls. The activated clusters were significantly positive correlated with the severity of psychopathology on the PAS <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Bandelow1" target="_blank">[41]</a>. For visualization, we used a normalized template, provided by SPM 5- Software (single_subj_T1.nii).</p

Intensity and hedonic ratings.

<p>Displayed are mean values and one-sided standard deviations for artificial odors (peach, artificial sweat) and own body odors (TSST sweat, ergometry sweat) in patients with PD and healthy controls. Intensity Ratings: 0 (no odor) − 10 (very strong intensity); Hedonic rating: −5 (very unpleasant) − +5 (very pleasant). ***p ≤.001, **p ≤.01</p

Characteristics of patients with Panic Disorder (PD) (N = 13) and healthy controls (N = 13). Displayed are the means and standard deviations (S.D.) or percentages.

***<p>p<.001, **p<.01; *p<.05; † Chi-square test; U =  Mann-Whitney U-Test; ACQ  =  Agoraphobic Cognitions Questionnaire <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Chambless1" target="_blank">[42]</a>; BDI  =  Beck-Depression-Inventory <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Hautzinger1" target="_blank">[39]</a>; BSQ  =  Body Sensations Questionnaire <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Chambless1" target="_blank">[42]</a>; ergo  =  ergometry; GSI  =  General-Symptom-Index <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Franke1" target="_blank">[40]</a>; MI  =  Mobility Inventory <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Chambless2" target="_blank">[43]</a>; PAS  =  Panic and Agoraphobia- Scale <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Bandelow1" target="_blank">[41]</a>; SCL  =  Symptom Check List <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Franke1" target="_blank">[40]</a>; STAI  =  State-Trait-Anxiety-Inventory <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Laux1" target="_blank">[44]</a>.</p

increases in brain activity under the presentation of artificial odors.

<p>Brain activation for the contrast artificial odors > no odor for the pooled odors peach and artificial sweat for patients with PD (N = 13), controls (N = 13) and for patients > controls/controls > patients. Whole brain analyses are corrected at cluster level and uncorrected at a height threshold of p<.001.</p><p>All activations are significant at p<.05, corrected for multiple comparisons at the cluster level (with a height threshold of p<.001, uncorrected). 1 = p<.05 in a hypothesis-driven region-of-interest (ROI) analysis. Brain masks were created using WFU PickAtlas. 2 = p<.05 in a hypothesis-driven region-of-interest (ROI) analysis according to the coordinates reported by by Pillay et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Pillay1" target="_blank">[25]</a> for the anterior cingulate cortex [−2 16 −4].</p><p># indicates that this activation maximum is part of the same cluster.</p><p>For each region of activation, the coordinates of the maximally activated voxels within the activation cluster are given in standard stereotactic MNI space.</p

Activated clusters for the contrast artificial odors (peach, artificial sweat) > no odor.

<p>The contrast is displayed for the healthy controls compared to patients with PD (K≥10, p<.05). For visualization a normalized template provided by SPM5-Software (single_subj_T1.nii) was used. *p<.05 in a hypothesis-driven region-of-interest (ROI) analysis according to the coordinates reported by Pillay et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Pillay1" target="_blank">[25]</a> for the anterior cingulate cortex [−2 16 −4].</p

Relative increases in brain activity under the presentation of own body odors.

<p>Brain activation for the contrast own body odors > no odor for the pooled odors TSST sweat and ergometry sweat for patients with PD (N = 13), controls (N = 13) and for patients > controls/controls > patients. Whole brain analyses are corrected at cluster level and uncorrected at a height threshold of p<.001.</p><p>All activations are significant at p<.05, corrected for multiple comparisons at the cluster level (with a height threshold of p<.001, uncorrected).</p><p>1 = p<.05 in a hypothesis-driven region-of-interest (ROI) analysis. Brain masks were created using WFU PickAtlas. 2 = p<.05 in a hypothesis-driven region-of-interest (ROI) analysis according to the coordinates reported by Wittmann et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0074655#pone.0074655-Wittmann1" target="_blank">[30]</a> for the inferior frontal gyrus [45 30 −15].</p><p># indicates that this activation maximum is part of the same cluster.</p><p>For each region of activation, the coordinates of the maximally activated voxels within the activation cluster are given in standard stereotactic MNI space.</p

Additional file 2: of Self-reported fatigue following intensive care of chronically critically ill patients: a prospective cohort study

Table S2. Descriptive characteristics of chronically critically ill (CCI) patients (n = 91) and the subsamples of patients with high fatigue (n = 45) vs. low fatigue (n = 46) at 6 months (t2) following the discharge from ICU at acute care hospital. aSubsamples were generated using the cutoff score 53+ suggested by Kuhnt et al. [32]; bStatistical value and p value refer to the comparison between the subsamples of patients with high fatigue vs. low fatigue; cp value from Mann-Whitney U test; dp value from chi-squared test; en = 5 missing values; high fatigue: n = 2, low fatigue: n = 3; fp value from Fisher’s exact test; gn = 1 brain, n = 3 central venous catheter, n = 1 urinary catheter; high fatigue: n = 1 brain, n = 1 central venous catheter, low fatigue: n = 1 urinary catheter, n = 2 central venous catheter; IQR = interquartile range, *p ≤ .05. (DOCX 22 kb

Additional file 1: of Fatigue in chronically critically ill patients following intensive care - reliability and validity of the multidimensional fatigue inventory (MFI-20)

Table S3. MFI-20 models tested via Confirmatory Factor Analysis (CFA) in n = 91 patients six months post-ICU (t3). (DOCX 16 kb

Additional file 3: of Self-reported fatigue following intensive care of chronically critically ill patients: a prospective cohort study

Table S3. Univariate linear regression for the identification of sociodemographic, clinical, and psychological predictors of total fatigue as measured with the MFI-20 in chronically critically ill patients (N = 113) 3 months following the discharge from ICU at acute care hospital. 1n = 7 missing values; 2n = 1 missing value; 3n = 2 missing values; ASDS = Acute Stress Disorder Scale; ASD = Acute Stress Disorder; CAM-ICU = Confusion Assessment Method for the Intensive Care Unit; MFI-20 = Multidimensional Fatigue Inventory; MSPSS = Multidimensional Scale of Perceived Social Support; PTSD = Posttraumatic Stress Disorder; SCID I = Structured Clinical Interview according to DSM IV; *p ≤ .05, **p ≤ .01, ***p ≤ .001. (DOCX 18 kb

Additional file 3: of Fatigue in chronically critically ill patients following intensive care - reliability and validity of the multidimensional fatigue inventory (MFI-20)

Table S2. Correlation coefficients of the MFI-20 items with the subscales. The item-subscale correlation coefficients are significant with **p < .01 or ***p < .001. (DOCX 15 kb