Additional file 1: of The barriers and facilitators to smoking cessation experienced by women’s partners during pregnancy and the post-partum period: a systematic review of qualitative research

Contains the full search strategy used for the systematic review. (PDF 85 kb

MOESM1 of A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments

Additional file 1. Sample search strategy for MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R) 1946 to Presen

MOESM4 of A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments

Additional file 4. Table S3Meta-analysis of published studies examining sustained virologic response among people with Hepatitis C treated in a variety of community settings or specialist hospital care

MOESM2 of A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments

Additional file 2. Table S1 Assessment of risk of bias for included studies – Newcastle/Ottawa Assessment non-randomised studies

MOESM3 of A systematic review and meta-analysis of community and primary-care-based hepatitis C testing and treatment services that employ direct acting antiviral drug treatments

Additional file 3. Table S2 Cochrane Assessment of Randomised Studies

Content featured in the ten bingo websites analysed.

<p>Content featured in the ten bingo websites analysed.</p

Themes and coding examples for qualitative interviews with bingo players.

Themes and coding examples for qualitative interviews with bingo players.</p

Weak evidence on nalmefene creates dilemmas for clinicians and poses questions for regulators and researchers

Background and aims: Nalmefene has been approved in Europe for the treatment of alcohol dependence and subsequently recommended by the UK National Institute for Health and Care Excellence (NICE). This study examines critically the evidence base underpinning both decisions and the issues arising. Methods: Published studies of nalmefene were identified through a systematic search, with documents from the European Medicines Agency, the NICE appraisal and public clinical trial registries also examined to identify methodological issues. Results: Efficacy data used to support the licensing of nalmefene suffer from risk of bias due to lack of specification of a priori outcome measures and sensitivity analyses, use of post-hoc sample refinement and the use of inappropriate comparators. Despite this, evidence for the efficacy of nalmefene in reducing alcohol consumption in those with alcohol dependence is, at best, modest, and of uncertain significance to individual patients. The relevance of existing trial data to routine primary care practice is doubtful. Conclusions: Problems with the registration, design, analysis and reporting of clinical trials of nalmefene did not prevent it being licensed and recommended for treating alcohol dependence. This creates dilemmas for primary care clinicians and commissioning organisations where nalmefene has been heavily promoted, and poses wider questions about the effectiveness of the medicines regulation system and how to develop the alcohol treatment evidence base

Themes in the qualitative content analysis of online bingo sites.

<p>Themes in the qualitative content analysis of online bingo sites.</p

Additional file 1: of Facilitators and barriers to the delivery of school-based smoking prevention interventions for children and young people: a protocol for a systematic review of qualitative studies

PRISMA-P checklist. (DOCX 29 kb