MFD lens profile compared with choroidal thickness changes.

(A) Concentric structure of the MFD lens consisting of a 2.3 mm center with distance prescription and a progressive addition zone up to 8.5 mm. (B) Horizontal power profile of the MFD lens as measured and adapted from Wagner et al. [25]. (C) Changes in choroidal thickness from temporal to nasal retina after wearing the MFD lens for 30 min in the present study. The bars represent the temporal perifoveal, temporal parafoveal, central, subfoveal, central, nasal parafoveal and nasal perifoval retinal ETDRS area from left to right.</p

Study procedure of the main study.

Subjects underwent OCT and biometry measurements before and after 30 min of contact lens wear. This was followed by a 15 min wash-out period with trial frame correction. The procedure was repeated for each of the four contact lenses. The left eye was constantly wearing trial frame correction while undergoing the same measurements at the same time points as the right eye.</p

Choroidal and vitreous chamber depth (VCD) changes.

Comparison of the lens-induced changes on the central ChT and vitreous chamber depth (VCD) between both eyes for every applied contact lens. General shortening from baseline of the vitreous chamber depth versus thickening of the choroid, whereas the left eye most commonly showed higher response rates. Errorbars indicate the standard deviation.</p

Absolute choroidal thickness changes with different lenses.

Absolute ChT changes of the right eye with different contact lenses, split by ETDRS regions and averaged over the total macular area. The error bars indicating the standard deviation imply a highly individual variability in choroidal reactions.</p

Applied contact lenses with parameters.

Applied contact lenses with parameters.</p

Diurnal choroidal rhythm with different corrections.

Central choroidal thickness changes for n = 3 subjects from 9 am to 5 pm. The ChT in the afternoon was significantly thinner compared to the morning values only with the spectacle correction only (9 am to 3 pm: p = 0.03; 9 am to 5 pm: p = 0.008). There was less thinning with both multifocal contact lenses. The horizontal offset of the values at each time point is only for reasons of clarity. Errorbars indicate the standard deviation.</p

MFN lens profile compared with choroidal thickness changes.

(A) Concentric structure of the MFD lens consisting of a 1.7 mm center with distance prescription and a progressive addition zone up to 8.5 mm. (B) Horizontal power profile of the MFN lens as measured and adapted from Wagner et al. [25]. (C) Changes in choroidal thickness from temporal to nasal retina after wearing the MFN lens for 30 min in the present study. The bars represent the temporal perifoveal, temporal parafoveal, central, subfoveal, central, nasal parafoveal and nasal perifoval retinal ETDRS area from left to right.</p

Uncorrected peripheral refraction.

The average uncorrected eccentric refraction profiles are divided into three groups: NPS, RPH and RPM. Visualization clearly shows the distinct behavior of the peripheral refractive error compared to the central refractive error of the different groups. Error bars indicate the standard deviation and are plotted only for every third angle of measurement for reasons of clarity.</p

Supplementary document for ON and OFF receptive field processing in the presence of optical scattering - 6387573.pdf

Figure S1: Visualization of the results from Figure 3 but with individual data points