Knowledge and attitudes about newborn screening for Fabry disease

Newborn screening is a public health program that identifies newborns who are at risk of having a life-threatening condition that will affect their health in infancy or childhood. Fabry disease is an X-linked lysosomal storage disorder with a variable age of onset from childhood through adulthood that was recently added to a few states’ newborn screening panels. Research on patient attitudes towards newborn screening for Fabry disease has been limited and this qualitative study aimed to gain a more complete understanding of the reasoning of adults with Fabry disease regarding the appropriateness of newborn screening for Fabry disease, their knowledge of newborn screening, and their experiences with Fabry disease. Participants were recruited from Children’s Hospital of Pittsburgh of UPMC’s Lysosomal Storage Disorders Clinic and six adults who have Fabry disease were interviewed. These interviews were transcribed and thematic analysis revealed six themes: influences of clinical spectrum and severity of Fabry disease, support systems, family dynamics, impact of timing of diagnosis and treatment availability on attitudes towards newborn screening, knowledge and attitudes towards newborn screening for Fabry disease, and impact of earlier diagnosis. Based on their personal experiences with Fabry disease, all participants were in favor of newborn screening for Fabry disease. Participants’ experiences with Fabry disease also reflected aspects of their family dynamics. The results of this qualitative study can inform genetic counseling practice for Fabry disease and future studies on NBS for Fabry disease. The opinions of stakeholders, including patients affected by the condition, are of public health significance and the results of this study can inform public health decisions as state legislators and state newborn screening programs consider whether to include Fabry disease on their state’s newborn screening panel

Data for: Adaptive Digital Combining for Coherent Free Space Optical Communications with Spatial Diversity Reception

1.Simulation data.rar contains two parts corresponding to the simulation data based on BPSK modulation and QPSK modulation respectively. 2.Simulation results (Fig. 3-Fig.6) in the paper is based on the data in the upload file. 3.Simulations are carried out by Matlab software and Optisystem software

Effects of probiotics consumption on lowering lipids and CVD risk factors: A systematic review and meta-analysis of randomized controlled trials

<div><p>This meta-analysis examined the effect of probiotics on the reduction of lipid components and coexisting risk factors associated with cardiovascular disease. All randomized controlled trials published in English on PubMed and Scopus from 2000 to 2014 were systematically searched. Using the PEDro scale to assess the quality of studies, a total of 15 studies with 788 subjects were selected for inclusion in the analysis. The mean difference and effect size with a 95% confidence interval (CI) were extracted from individual studies. Statistically significant pooled effects of probiotics were found on reduction of total cholesterol, low-density lipoprotein (LDL), body mass index (BMI), waist circumference, and inflammatory markers. Subgroup analysis revealed statistically significant effects of probiotics on total cholesterol and LDL when the medium was fermented milk or yogurt (<i>P</i> < 0.001) compared to capsule form, consumption was at least 8 weeks in duration (<i>P</i> < 0.001), and the probiotics consisted of multiple strains (<i>P</i> < 0.001) rather than a single strain. A significant reduction was found in LDL in trials which contained <i>Lactobacillus Acidophilus</i> strain (<i>P</i> < 0.001) compared to other types of strains. Our findings suggest that probiotic supplementation use is effective in lowering the lipid level and coexisting factors associated with cardiovascular disease.</p></div

Suppression and Enhancement of Thermal Chemical Rates in a Cavity

The observed modification of thermal chemical rates in Fabry–Perot cavities remains a poorly understood effect theoretically. Recent breakthroughs explain some of the observations through the Grote–Hynes theory, where the cavity introduces friction with the reaction coordinate, thus reducing the transmission coefficient and the rate. The regime of rate enhancement, the observed sharp resonances at varying cavity frequencies, and the survival of these effects in the collective regime remain mostly unexplained. In this Letter, we consider the cis–trans isomerization of HONO atomistically using an ab initio potential energy surface. We evaluate the transmission coefficient using the reactive flux method and identify the conditions for rate acceleration. In the underdamped, low-friction regime of the reaction coordinate, the cavity coupling enhances the rate with increasing coupling strength until reaching the Kramers turnover point. Sharp resonances in this regime are related to cavity-enabled energy redistribution channels

Additional file 2 of Association between atherogenic index of plasma and periodontitis among U.S. adults

Supplementary Table 2. Adjusted multinomial logistic regression of AIP with periodontiti

Thiol−Ene Clickable Polypeptides

Thiol−Ene Clickable Polypeptide

Modification of Thermal Chemical Rates in a Cavity via Resonant Effects in the Collective Regime

The modification of thermal chemical rates in Fabry–Perot cavities, as observed in experiments, still poses theoretical challenges. While we have a better grasp of how the reactivity of isolated molecules and model systems changes under strong coupling, we lack a comprehensive understanding of the combined effects and the specific roles played by activated and spectator molecules during reactive events. In this study, we investigate an ensemble of randomly oriented gas-phase HONO molecules undergoing a cis–trans isomerization reaction on an ab initio potential energy surface. One thermally activated molecule can overcome the reaction barrier, while the other molecules are nonactivated but coupled to the cavity as well. Using the classical reactive flux method, we analyze the transmission coefficient and determine the conditions that lead to accelerated rates within the collective regime. We identify two main mechanistic aspects: First, nonactivated molecules enhance the cavity’s ability to dissipate excess energy from the activated molecule postreactive event. Second, the activated molecule couples with the polaritonic resonance created by the nonactivated molecules and the cavity at a shifted resonance frequency with respect to the bare cavity

Mesalazine Modified-Release Tablet in the Treatment of Ulcerative Colitis in the Remission Phase: A Chinese, Multicenter, Single-Blind, Randomized Controlled Study

Article full text The full text of this article can be found here. https://link.springer.com/article/10.1007/s12325-016-0304-y Provide enhanced content for this article If you are an author of this publication and would like to provide additional enhanced content for your article then please contact [email protected]. The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content. Other enhanced features include, but are not limited to: • Slide decks • Videos and animations • Audio abstracts • Audio slides</p

Additional file 1 of Association between atherogenic index of plasma and periodontitis among U.S. adults

Supplementary Table 1. Periodontitis is classified according to the US CDC-AA

Modification of Thermal Chemical Rates in a Cavity via Resonant Effects in the Collective Regime

The modification of thermal chemical rates in Fabry–Perot cavities, as observed in experiments, still poses theoretical challenges. While we have a better grasp of how the reactivity of isolated molecules and model systems changes under strong coupling, we lack a comprehensive understanding of the combined effects and the specific roles played by activated and spectator molecules during reactive events. In this study, we investigate an ensemble of randomly oriented gas-phase HONO molecules undergoing a cis–trans isomerization reaction on an ab initio potential energy surface. One thermally activated molecule can overcome the reaction barrier, while the other molecules are nonactivated but coupled to the cavity as well. Using the classical reactive flux method, we analyze the transmission coefficient and determine the conditions that lead to accelerated rates within the collective regime. We identify two main mechanistic aspects: First, nonactivated molecules enhance the cavity’s ability to dissipate excess energy from the activated molecule postreactive event. Second, the activated molecule couples with the polaritonic resonance created by the nonactivated molecules and the cavity at a shifted resonance frequency with respect to the bare cavity