Submission of Evidence on Online Violence Against Women to the UN Special Rapporteur on Violence Against Women, its Causes and Consequences, Dr Dubravka Šimonović

Figure S1. B3GALNT2 levels determined by W.B. and ROC curve. a–c Relative mRNA expression of B3GALNT2 in HCC tumor tissues and normal liver tissues obtained from GSE76427, GSE36376, and TCGA-LIHC datasets. d Western blot analysis of B3GALNT2 levels in 24 pairs of HCC tissues. T HCC tumor tissue, N adjacent non-tumor tissue. e ROC curve analysis of the sensitivity and specificity for the predictive value of TNM model, B3GALNT2 expression, and the combination model. (TIFF 546 kb

Online Classroom dengan Pemanfaatan K12lessonplans Bagi Guru-guru SMP. H. Isriati Semarang

This society service is carried out using a free teacher website;www.k12lessonplans.com, in a form of training for teachers at SMP. H.Isriati Semarang. There are 15 teachers joining this training, which is heldon 14 ?óÔé¼ÔÇ£ 16 July, 2012, starting from 09:00 am - 02:00 pm. This trainingtakes place in the Computer Laboratory group and individual audience isconducted consecutively from 17 ?óÔé¼ÔÇ£ 21 July, 2012 and 23 ?óÔé¼ÔÇ£ 26 July startingfrom 02:00 ?óÔé¼ÔÇ£ 04:00 pm in the teachers?óÔé¼Ôäó longue at the school. This programis aimed to give the teachers knowledge and training, to implement onlineclassroom using the website. The methods used in this program are;explanation, question and answer, training and group guidance

Applying System of Systems Engineering(SoSE) to VIVO?

System of systems (SoS) refers to a set of operational and managerial independent systems interacting with each other to provide capabilities which cannot be accomplished by any single system. SoS has its own characteristics and challenges, such as emergent behavior and evolutionary development. This presentation will: <br><br>Introduce the concepts and characteristics of system of systems (SoS) and system thinking practice. <br>discuss SoS challenges using SoS case studies such as Global Earth Observation SoS <br>discuss how SoS Engineering process can be applied to networked research ecosystem in various areas such as community partnerships and SoS architecture

Polymeric Self-Assembly into Micelles and Hollow Spheres with Multiscale Cavities Driven by Inclusion Complexation

The inclusion complexation between β-CD (β-cyclodextrin) and adamantyl group (ADA) is used as a driving force in constructing polymeric micelles. The micelles composed of a hydrophobic core of PtBA-ADA and a hydrophilic shell of PGMA-CD show unique properties due to the presence of β-CDs on the micellar surface. The micelles can be converted to hollow spheres of PGMA-CD networks. The hollow spheres possess a central hole in the size of submicrometers and many cavities of β-CDs of 0.7 nm on the surface

Interaction of Heparin with Two Synthetic Peptides that Neutralize the Anticoagulant Activity of Heparin^†

Two synthetic analogues of the heparin-binding domain of heparin/heparan sulfate-interacting protein (Ac-SRGKAKVKAKVKDQTK-NH2) and the all-d-amino acid version of the same peptide (l-HIPAP and d-HIPAP, respectively) were synthesized, and their efficacy as agents for neutralization of the anticoagulant activity of heparin was assayed. The two analogue peptides were found to be equally effective for neutralization of the anticoagulant activity of heparin, as measured by restoration of the activity of serine protease factor Xa by the Coatest heparin method. The finding that l-HIPAP and d-HIPAP are equally effective suggests that d-amino acid peptides show promise as proteolytically stable therapeutic agents for neutralization of the anticoagulant activity of heparin. The interaction of l-HIPAP and d-HIPAP with heparin was characterized by 1H NMR, isothermal titration calorimetry (ITC), and heparin affinity chromatography. The two peptides were found to interact identically with heparin. Analysis of the dependence of heparin−peptide binding constants on Na+ concentration by counterion condensation theory indicates that, on average, 2.35 Na+ ions are displaced from heparin per peptide molecule bound and one peptide molecule binds per hexasaccharide segment of heparin. The analysis also indicates that both ionic and nonionic interactions contribute to the binding constant, with the ionic contribution decreasing as the Na+ concentration increases

Highly Convergent Route to Cyclopeptide Alkaloids. Total Synthesis of Ziziphine N

A highly convergent protocol to cyclopeptide alkaloids, as demonstrated by the first total synthesis of antiplasmodial agent ziziphine N, is developed. The key elements include construction of its aryl ether unit via Mitsunobu reaction, installation of its enamide part via CuI/N,N-dimethylglycine-catalyzed coupling reaction, and ring closure with coupling agents such as FDDP and DPPA

Cooperative Effects: Stabilization of the Isoguanine Trimer

Isoguanine (isoG) trimers have been theoretically studied using the density functional theory to reveal the role of H-bonding in the formation of different base aggregations. Similar to the isoG tetrads, the isoG trimer also adopts diverse conformations. Cooperative effects for the H-bonding in the cyclic isoG trimers have been found to be important. As a result of the strong cooperativity, the conformer characterized by the highest symmetry is the most stable among the possible trimers. Vibration mode analysis reveals the influence of the cooperative effects on the H-bond stretching motion. An atoms-in-molecules study of the H-bonds in the isoG trimers suggests that the electronic density topology of the bifurcated H-bond is insensitive to the cooperative effects. The values of the binding energy, the vibration frequency, and the electronic density topology of the noncyclic isoG trimers demonstrate that there is no cooperativity in these open ring structures

H−Bonding Patterns in the Platinated Guanine−Cytosine Base Pair and Guanine−Cytosine−Guanine−Cytosine Base Tetrad: an Electron Density Deformation Analysis and AIM Study

The atoms in molecule theory (AIM) and electronic structure analysis are applied together to investigate H-bonding patterns in metalated nucleobase complexes. The influence of Pt on the intra GC base pair H-bonding has been found to reduce intra base pair H-bonding of N4(C)···O6(G) in the platinated GC pair and GCGC tetrad. The relaxation of geometry constrains in metalated nucleobases is found to be decisively important in the formation of novel molecular architectures from nucleobases and metal entities. The incorporation of the platinum in the GCGC tetrad benefits the formation of the unique CH···N (H5(C)···N1(G)) hydrogen bond pattern in the tetrad by offering improved geometric constraints rather than through changing the electronic properties around the H5(C) and N1(G) sites. Platination at the N7 of guanine reduces the deprotonation energy considerably

Copper-Catalyzed Multicomponent Reaction: Facile Access to Novel Phosphorus Amidines

The synthesis of a novel class of phosphorus amidines via a copper-catalyzed multicomponent reaction of sulfonyl azides, alkynes and iminophosphoranes is described. The protocol is efficient and general

Copper-Catalyzed Multicomponent Reaction: Facile Access to Functionalized 5-Arylidene-2-imino-3-pyrrolines

The synthesis of a novel class of 2-imino-5-arylidene-3-pyrrolines via a copper-catalyzed multicomponent reaction of sulfonyl azides with alkynes and aziridines is described. The protocol is efficient and general