Was the first industrial revolution a conjuncture in the history of the world economy?

Quantitative analysis of flavonoids in flower petals of Nymphaea ‘King of Siam’. (DOCX 18 kb

iso- and OH-GDGTs data in 74 surface sediment from 65 West China lakes

 iso- and OH-GDGTs data in 74 surface sediment from 65 West China lakes. </p

Efficient Generation of Biologically Active <i>H</i>-Pyrazolo[5,1-<i>a</i>]isoquinolines via Multicomponent Reaction

A highly efficient multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, alcohol, and α,β-unsaturated aldehyde or ketone is disclosed, which generates the diverse H-pyrazolo[5,1-a]isoquinolines in good yields. This reaction proceeds with good functional group tolerance under mild conditions with high efficiency and excellent selectivity. Preliminary biological assays show that some of these compounds display promising activities as CDC25B inhibitor, TC-PTP inhibitor, and PTP1B inhibitor

Synthesis of <i>H</i>-Pyrazolo[5,1-<i>a</i>]isoquinolines via Copper(II)-Catalyzed Oxidation of an Aliphatic C−H Bond of Tertiary Amine in Air

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C−H bond of tertiary amine in air are involved

Synthesis of <i>H</i>-Pyrazolo[5,1-<i>a</i>]isoquinolines via Copper(II)-Catalyzed Oxidation of an Aliphatic C−H Bond of Tertiary Amine in Air

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C−H bond of tertiary amine in air are involved

Nickel-Catalyzed Cross-Couplings of 4-Diethylphosphonooxycoumarins with Organozinc Reagents: An Efficient New Methodology for the Synthesis of 4-Substituted Coumarins

Nickel-Catalyzed Cross-Couplings of 4-Diethylphosphonooxycoumarins with Organozinc Reagents:  An Efficient New Methodology for the Synthesis of 4-Substituted Coumarin

Palladium-Catalyzed Hiyama Cross-Couplings of Aryl Arenesulfonates with Arylsilanes

Palladium-Catalyzed Hiyama Cross-Couplings of Aryl Arenesulfonates with Arylsilane

Synthesis of Arylphosphonates via Palladium-Catalyzed Coupling Reactions of Aryl Imidazolylsulfonates with H-Phosphonate Diesters

A palladium-catalyzed reaction of an aryl imidazolylsulfonate with an H-phosphonate diester in the presence of DPPP and iPr2NEt is described. The reactions proceed efficiently to generate the corresponding arylphosphonates in good to excellent yields. The advantages of this method include good substrate generality, high efficiency, and experimental ease

Synthesis of <i>H</i>-Pyrazolo[5,1-<i>a</i>]isoquinolines via Copper(II)-Catalyzed Oxidation of an Aliphatic C−H Bond of Tertiary Amine in Air

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C−H bond of tertiary amine in air are involved

Sc(OTf)₃-Catalyzed or <i>t</i>-BuOK Promoted Tandem Reaction of 2-(2-(Alkynyl)benzylidene)malonate with Indole

Tandem reaction of 2-(2-(alkynyl)benzylidene)malonate with indole was investigated. (Z)-1-Benzylidene-3-(1H-indol-1-yl)-1H-indene-2,2(3H)-dicarboxylate was generated in the presence of t-BuOK at room temperature; whereas 3-((1H-indol-3-yl)(2-(alkynyl)aryl)methyl)-1H-indole was obtained when Sc(OTf)3 was utilized as catalyst at 50 °C