43 research outputs found
Construction and Analyses of Human Large-Scale Tissue Specific Networks
<div><p>Construction and analyses of tissue specific networks is crucial to unveil the function and organizational structure of biological systems. As a direct method to detect protein dynamics, human proteome-wide expression data provide an valuable resource to investigate the tissue specificity of proteins and interactions. By integrating protein expression data with large-scale interaction network, we constructed 30 tissue/cell specific networks in human and analyzed their properties and functions. Rather than the tissue specificity of proteins, we mainly focused on the tissue specificity of interactions to distill tissue specific networks. Through comparing our tissue specific networks with those inferred from gene expression data, we found our networks have larger scales and higher reliability. Furthermore, we investigated the similar extent of multiple tissue specific networks, which proved that tissues with similar functions tend to contain more common interactions. Finally, we found that the tissue specific networks differed from the static network in multiple topological properties. The proteins in tissue specific networks are interacting looser and the hubs play more important roles than those in the static network.</p></div
Tissue specific networks inferred from protein expression data.
<p>Tissue specific networks inferred from protein expression data.</p
Average topological indexes of tissue specific networks and the static network.
<p>Average topological indexes of tissue specific networks and the static network.</p
Highly Sensitive Mechanochromic Photonic Hydrogels with Fast Reversibility and Mechanical Stability
We present a fast and efficient strategy
for the preparation of
photonic hydrogels for compression and organic solvent sensing by
the self-assembly of monodisperse carbon-encapsulated Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs). The hydrogel film was composed
of acrylamide (AM) and cross-linker <i>N</i>,<i>N</i>′-methylenebisÂ(acrylamide) (BIS), and the formed 1D NPs chain
structure can be fixed within the hydrogels under a magnetic field
by in situ photopolymerization. The resulting photonic hydrogels display
vivid structural color which can be tuned by pressing and organic
solvent treatment. The 0.2 kPa compression applied to the photonic
hydrogels can be detected by the 37 nm blue shift of a reflection
peak. Importantly, the photonic hydrogels can recover to their original
state (<1 s) after being compressed on a pattern. Moreover, the
sensitivity of mechanochromic photonic hydrogels can be adjusted by
manipulating the concentration of monomers, and a large reflection
peak shift (4.3 kPa, 200 nm) was observed. The detection range of
the compression sensor can thus increase from 0–4.3 to 0–130.6
kPa. The photonic hydrogels are nearly monochromatic, with high sensitivity
and stability and fast reversibility, and are potentially useful in
displays, diagnostics, compression and solvent sensing
The distribution of proteins and interactions expressed in tissues/cells.
<p>The distribution of proteins and interactions expressed in tissues/cells.</p
Desulfurization Performance of Ether-Functionalized Imidazolium-Based Ionic Liquids Supported on Porous Silica Gel
Ether-functionalized
imidazolium-based ionic liquids (EFIILs) [C<sub>3</sub>O<sub>1</sub>Mim]Â[H<sub>3</sub>CSO<sub>3</sub>], [C<sub>5</sub>O<sub>2</sub>Mim]Â[H<sub>3</sub>CSO<sub>3</sub>], and [C<sub>7</sub>O<sub>3</sub>Mim]Â[H<sub>3</sub>CSO<sub>3</sub>] were supported onto
porous silica gel particles via a facile impregnation method. The
synthesized EFIILs/SiO<sub>2</sub> were characterized by Fourier transform
infrared spectroscopy (FTIR), scanning electron microscopy (SEM),
thermogravimetric analysis (TGA), and Brunauer–Emmett–Teller
(BET). Results show that the EFIILs/SiO<sub>2</sub> have good thermal
stability, high porosity, and large specific surface area. The ability
of both of the EFIILs and EFIILs/SiO<sub>2</sub> to reversibly absorb
gaseous sulfur dioxide (SO<sub>2</sub>) was experimentally investigated,
and high capacity and rate for SO<sub>2</sub> sorption were confirmed.
The capacities reached 2.621 mol of SO<sub>2</sub>/mol of [C<sub>3</sub>O<sub>1</sub>Mim]Â[H<sub>3</sub>CSO<sub>3</sub>], 3.106 mol of SO<sub>2</sub>/mol of [C<sub>5</sub>O<sub>2</sub>Mim]Â[H<sub>3</sub>CSO<sub>3</sub>], and 3.453 mol of SO<sub>2</sub>/mol of [C<sub>7</sub>O<sub>3</sub>Mim]Â[H<sub>3</sub>CSO<sub>3</sub>], which indicate that the
SO<sub>2</sub> sorption capacity increases with the increase of the
ether chain length in the cation at 25 °C. The EFIILs/SiO<sub>2</sub> have better adsorption properties than pure EFIILs, because
the supporting materials/porous silica gel played an important role
in the adsorption. The EFIILs/SiO<sub>2</sub> system could be reused
for several adsorption–desorption cycles without loss of its
initial capacity
Average overlap percent across different networks occupying each tissue specific network.
<p>Average overlap percent across different networks occupying each tissue specific network.</p
Hierarchically Structured CuCo<sub>2</sub>S<sub>4</sub> Nanowire Arrays as Efficient Bifunctional Electrocatalyst for Overall Water Splitting
Hydrogen
produced from water splitting offers a green alternative to conventional
energy such as fossil fuels. Herein, CuCo<sub>2</sub>S<sub>4</sub> nanowire arrays were synthesized on a nickel foam substrate by a
two-step hydrothermal approach and utilized as highly efficient bifunctional
electrocatalyst for overall water splitting. The CuCo<sub>2</sub>S<sub>4</sub> nanowire arrays were identified as an exceptionally active
catalyst for the hydrogen evolution reaction (HER) in a basic solution
with an extremely low overpotential of 65 mV to reach a current density
of 10 mA/cm<sup>2</sup>. The hierarchically structured CuCo<sub>2</sub>S<sub>4</sub> electrode was also highly active toward the oxygen
evolution reaction (OER), achieving a high current density of 100
mA/cm<sup>2</sup> at an overpotential of only 310 mV. Consequently,
an alkaline electrolyzer constructed using CuCo<sub>2</sub>S<sub>4</sub> nanowire arrays as both anode and cathode can realize overall water
splitting with a current density of 100 mA/cm<sup>2</sup> at a cell
voltage of 1.65 V, suggesting a promising bifunctional electrocatalyst
for efficient overall water splitting