43 research outputs found

    Construction and Analyses of Human Large-Scale Tissue Specific Networks

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    <div><p>Construction and analyses of tissue specific networks is crucial to unveil the function and organizational structure of biological systems. As a direct method to detect protein dynamics, human proteome-wide expression data provide an valuable resource to investigate the tissue specificity of proteins and interactions. By integrating protein expression data with large-scale interaction network, we constructed 30 tissue/cell specific networks in human and analyzed their properties and functions. Rather than the tissue specificity of proteins, we mainly focused on the tissue specificity of interactions to distill tissue specific networks. Through comparing our tissue specific networks with those inferred from gene expression data, we found our networks have larger scales and higher reliability. Furthermore, we investigated the similar extent of multiple tissue specific networks, which proved that tissues with similar functions tend to contain more common interactions. Finally, we found that the tissue specific networks differed from the static network in multiple topological properties. The proteins in tissue specific networks are interacting looser and the hubs play more important roles than those in the static network.</p></div

    Tissue specific networks inferred from protein expression data.

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    <p>Tissue specific networks inferred from protein expression data.</p

    Average topological indexes of tissue specific networks and the static network.

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    <p>Average topological indexes of tissue specific networks and the static network.</p

    Highly Sensitive Mechanochromic Photonic Hydrogels with Fast Reversibility and Mechanical Stability

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    We present a fast and efficient strategy for the preparation of photonic hydrogels for compression and organic solvent sensing by the self-assembly of monodisperse carbon-encapsulated Fe<sub>3</sub>O<sub>4</sub> nanoparticles (NPs). The hydrogel film was composed of acrylamide (AM) and cross-linker <i>N</i>,<i>N</i>′-methylenebis­(acrylamide) (BIS), and the formed 1D NPs chain structure can be fixed within the hydrogels under a magnetic field by in situ photopolymerization. The resulting photonic hydrogels display vivid structural color which can be tuned by pressing and organic solvent treatment. The 0.2 kPa compression applied to the photonic hydrogels can be detected by the 37 nm blue shift of a reflection peak. Importantly, the photonic hydrogels can recover to their original state (<1 s) after being compressed on a pattern. Moreover, the sensitivity of mechanochromic photonic hydrogels can be adjusted by manipulating the concentration of monomers, and a large reflection peak shift (4.3 kPa, 200 nm) was observed. The detection range of the compression sensor can thus increase from 0–4.3 to 0–130.6 kPa. The photonic hydrogels are nearly monochromatic, with high sensitivity and stability and fast reversibility, and are potentially useful in displays, diagnostics, compression and solvent sensing

    The distribution of proteins and interactions expressed in tissues/cells.

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    <p>The distribution of proteins and interactions expressed in tissues/cells.</p

    Desulfurization Performance of Ether-Functionalized Imidazolium-Based Ionic Liquids Supported on Porous Silica Gel

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    Ether-functionalized imidazolium-based ionic liquids (EFIILs) [C<sub>3</sub>O<sub>1</sub>Mim]­[H<sub>3</sub>CSO<sub>3</sub>], [C<sub>5</sub>O<sub>2</sub>Mim]­[H<sub>3</sub>CSO<sub>3</sub>], and [C<sub>7</sub>O<sub>3</sub>Mim]­[H<sub>3</sub>CSO<sub>3</sub>] were supported onto porous silica gel particles via a facile impregnation method. The synthesized EFIILs/SiO<sub>2</sub> were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET). Results show that the EFIILs/SiO<sub>2</sub> have good thermal stability, high porosity, and large specific surface area. The ability of both of the EFIILs and EFIILs/SiO<sub>2</sub> to reversibly absorb gaseous sulfur dioxide (SO<sub>2</sub>) was experimentally investigated, and high capacity and rate for SO<sub>2</sub> sorption were confirmed. The capacities reached 2.621 mol of SO<sub>2</sub>/mol of [C<sub>3</sub>O<sub>1</sub>Mim]­[H<sub>3</sub>CSO<sub>3</sub>], 3.106 mol of SO<sub>2</sub>/mol of [C<sub>5</sub>O<sub>2</sub>Mim]­[H<sub>3</sub>CSO<sub>3</sub>], and 3.453 mol of SO<sub>2</sub>/mol of [C<sub>7</sub>O<sub>3</sub>Mim]­[H<sub>3</sub>CSO<sub>3</sub>], which indicate that the SO<sub>2</sub> sorption capacity increases with the increase of the ether chain length in the cation at 25 °C. The EFIILs/SiO<sub>2</sub> have better adsorption properties than pure EFIILs, because the supporting materials/porous silica gel played an important role in the adsorption. The EFIILs/SiO<sub>2</sub> system could be reused for several adsorption–desorption cycles without loss of its initial capacity

    Average overlap percent across different networks occupying each tissue specific network.

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    <p>Average overlap percent across different networks occupying each tissue specific network.</p

    Hierarchically Structured CuCo<sub>2</sub>S<sub>4</sub> Nanowire Arrays as Efficient Bifunctional Electrocatalyst for Overall Water Splitting

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    Hydrogen produced from water splitting offers a green alternative to conventional energy such as fossil fuels. Herein, CuCo<sub>2</sub>S<sub>4</sub> nanowire arrays were synthesized on a nickel foam substrate by a two-step hydrothermal approach and utilized as highly efficient bifunctional electrocatalyst for overall water splitting. The CuCo<sub>2</sub>S<sub>4</sub> nanowire arrays were identified as an exceptionally active catalyst for the hydrogen evolution reaction (HER) in a basic solution with an extremely low overpotential of 65 mV to reach a current density of 10 mA/cm<sup>2</sup>. The hierarchically structured CuCo<sub>2</sub>S<sub>4</sub> electrode was also highly active toward the oxygen evolution reaction (OER), achieving a high current density of 100 mA/cm<sup>2</sup> at an overpotential of only 310 mV. Consequently, an alkaline electrolyzer constructed using CuCo<sub>2</sub>S<sub>4</sub> nanowire arrays as both anode and cathode can realize overall water splitting with a current density of 100 mA/cm<sup>2</sup> at a cell voltage of 1.65 V, suggesting a promising bifunctional electrocatalyst for efficient overall water splitting
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